2,4-dichlorobenzoyl-CoA reductase

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In enzymology, a 2,4-dichlorobenzoyl-CoA reductase (EC is an enzyme that catalyzes the chemical reaction

4-chlorobenzoyl-CoA + NADP+ + HCl 2,4-dichlorobenzoyl-CoA + NADPH + H+

The 3 substrates of this enzyme are 4-chlorobenzoyl-CoA, NADP+, and HCl, whereas its 3 products are 2,4-dichlorobenzoyl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating). This enzyme participates in 2,4-dichlorobenzoate degradation.


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  • Romanov V, Hausinger RP (1996). "NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A". J. Bacteriol. 178: 2656&ndash, 61. PMID 8626335.

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Gene Ontology (GO) codes