(R)-2-haloacid dehalogenase

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In enzymology, a (R)-2-haloacid dehalogenase (EC is an enzyme that catalyzes the chemical reaction

(R)-2-haloacid + H2O (S)-2-hydroxyacid + halide

Thus, the two substrates of this enzyme are (R)-2-haloacid and H2O, whereas its two products are (S)-2-hydroxyacid and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is (R)-2-haloacid halidohydrolase. Other names in common use include 2-haloalkanoic acid dehalogenase[ambiguous], 2-haloalkanoid acid halidohydrolase[ambiguous], D-2-haloacid dehalogenase, and D-DEX.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Smith JM, Harrison K, Colby J (1990). "Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23". J. Gen. Microbiol. 136: 881&ndash, 6. PMID 2380688.
  • Leigh JA, Skinner AJ and Cooper RA (1988). "Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species". FEMS Microbiol. Lett. 49: 353&ndash, 356.
  • M, Tsunasawa S and Esaki N (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68: 2097&ndash, 2103.

External links

The CAS registry number for this enzyme class is 119345-29-8.