(-)-menthol monooxygenase

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In enzymology, a (-)-menthol monooxygenase (EC is an enzyme that catalyzes the chemical reaction

(-)-menthol + NADPH + H+ + O2 p-menthane-3,8-diol + NADP+ + H2O

The 4 substrates of this enzyme are (-)-menthol, NADPH, H+, and O2, whereas its 3 products are p-menthane-3,8-diol, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called l-menthol monooxygenase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Madyastha KM, Srivatsan V (1988). "Studies on the metabolism of l-menthol in rats". Drug. Metab. Dispos. 16: 765&ndash, 72. PMID 2906604.

External links

The CAS registry number for this enzyme class is 117590-75-7.

Gene Ontology (GO) codes