Zollinger-Ellison syndrome historical perspective: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{CMG}} {{AE}} {{ | |||
{{CMG}} {{AE}}{{S.M}} | |||
{{Zollinger-Ellison syndrome}} | {{Zollinger-Ellison syndrome}} | ||
==Overview== | ==Overview== | ||
In 1955, Zollinger and Ellison published their seminal paper on gastrinomas wherein the Zollinger-Ellison syndrome was first | In 1955, Zollinger and Ellison published their seminal paper on gastrinomas wherein the Zollinger-Ellison syndrome was discussed for the first time. | ||
==Historical Perspective== | ==Historical Perspective== | ||
*In 1955, Zollinger and Ellison | * In 1955, Zollinger and Ellison announced their concept about [[Ulcer|ulcerogenic]] [[islet cell]] [[tumor]] which caused marked [[ulcer]] diathesis due to [[Stomach|gastric]] hyperacidity.<ref name="pmid1746876">{{cite journal| author=Zollinger RM| title=[The history of the Zollinger-Ellison syndrome]. | journal=Ann Gastroenterol Hepatol (Paris) | year= 1991 | volume= 27 | issue= 5 | pages= 223-6 | pmid=1746876 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1746876 }} </ref> | ||
* Dr. Robert M. Zollinger and Dr. Edwin H. Ellison announced their theory at the annual meeting of American Surgical Association in Philadelphia in April 1956.<ref name="pmid13259432">{{cite journal| author=ZOLLINGER RM, ELLISON EH| title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. | journal=Ann Surg | year= 1955 | volume= 142 | issue= 4 | pages= 709-23; discussion, 724-8 | pmid=13259432 | doi= | pmc=1465210 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13259432 }} </ref> | |||
* This concept raised from [[clinical]] case of two women who presented with perforated [[Jejunum|jejunal]] [[Ulcer|ulcers]] accompanied with severe [[ulcer]] diathesis. | |||
* One of the [[patients]] was a 36 year-old woman with past history of 8 years [[abdominal pain]] and [[diarrhea]]. A [[laparotomy]] revealed [[Perforated ulcer|perforated]] [[Jejunum|jejunal]] [[Ulcer|ulcers]] with severe recurrent [[Bleeding|hemorrhage]]. Although she underwent two subtotal [[Stomach|gastric]] [[Resection|resections]], transabdominal [[vagotomy]], and transthoracic [[vagotomy]], her [[Symptom|symptoms]] were constantly persistent. Finally she underwent total [[gastrectomy]]; however, she died due to [[Anastomosis|anastomic]] leakage from the [[surgery]]. Her [[autopsy]] was in favor of non-beta [[Pancreas|pancreatic]] [[islet cell]] [[tumor]].<ref name="KaplanTanaka1994">{{cite journal|last1=Kaplan|first1=Edwin L.|last2=Tanaka|first2=Reiko|last3=Ito|first3=Koichi|last4=Younes|first4=Nidal|last5=Friesen|first5=Stanley R.|title=The discovery of the Zollinger-Ellison syndrome|journal=Journal of Hepato-Biliary-Pancreatic Surgery|volume=1|issue=5|year=1994|pages=509–516|issn=0944-1166|doi=10.1007/BF01211912}}</ref> | |||
* The other [[patient]] was a 19 year-old woman with 2 years of [[upper abdominal pain]]. She underwent a [[surgery]] in July 1953 and was [[Diagnosis|diagnosed]] with two [[Perforated ulcer|perforated]] [[Jejunum|jejunal]] [[Ulcer|ulcers]]. A truncal [[vagotomy]] and a radical subtotal [[gastrectomy]] were performed in January 1954. This operation was called a dream operation for [[Ulcer|ulcers]] by Zollinger. Due to unsuccessful results of the operation, she had to go through [[radiation therapy]] to her [[stomach]]. Eventually, total [[gastrectomy]] was performed. The results described a non-beta [[islet cell]] [[carcinoma]] with [[lymph node]] [[metastasis]]. | |||
* In 1956, Ben Eiseman of Denver, Colorado, presented the same experience with one of his [[Patient|patients]] and called the condition "Zollinger-Ellison syndrome".<ref name="pmid2757418">{{cite journal| author=Chey WY, Chang TM, Lee KY, Sun G, Kim CK, You CH et al.| title=Ulcerogenic tumor syndrome of the pancreas associated with a nongastrin acid secretagogue. | journal=Ann Surg | year= 1989 | volume= 210 | issue= 2 | pages= 139-49 | pmid=2757418 | doi= | pmc=1357819 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2757418 }}</ref> | |||
* Discovery of [[insulinoma]] in 1927 and [[malignant carcinoid syndrome]] in 1953, have exceeded the presentation and discovery of Zollinger-Ellison syndrome.<ref name="WilderAllan1927">{{cite journal|last1=Wilder|first1=Russell M.|last2=Allan|first2=Frank N.|last3=Power|first3=M. H.|last4=Robertson|first4=H. E.|title=CARCINOMA OF THE ISLANDS OF THE PANCREAS|journal=Journal of the American Medical Association|volume=89|issue=5|year=1927|pages=348|issn=0002-9955|doi=10.1001/jama.1927.02690050014007}}</ref><ref name="pmid24319020">{{cite journal| author=Epelboym I, Mazeh H| title=Zollinger-Ellison syndrome: classical considerations and current controversies. | journal=Oncologist | year= 2014 | volume= 19 | issue= 1 | pages= 44-50 | pmid=24319020 | doi=10.1634/theoncologist.2013-0369 | pmc=3903066 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24319020 }} </ref> | |||
*In the 1960s, [[gastrin]] was described to be involved in the [[pathogenesis]] of gastric hyperacidity by Dr. Lester.<ref name="pmid17053435">{{cite journal| author=Hou W, Schubert ML| title=Gastric secretion. | journal=Curr Opin Gastroenterol | year= 2006 | volume= 22 | issue= 6 | pages= 593-8 | pmid=17053435 | doi=10.1097/01.mog.0000245538.43142.87 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17053435 }} </ref> | |||
* Roderic Gregory and Hilda Tracy of Liverpool proved that [[gastrin]] is the cause of Zollinger-Ellison syndrome. <ref name="pmid3851712">{{cite journal| author=Leske JS| title=Hyperglycemic hyperosmolar nonketotic coma: a nursing care plan. | journal=Crit Care Nurse | year= 1985 | volume= 5 | issue= 5 | pages= 49-56 | pmid=3851712 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3851712 }}</ref> | |||
*[[Radioimmunoassay]] was developed for assessment of [[gastrin]] level in 1967 and 1968.<ref name="StrempleAbramoff1967">{{cite journal|last1=Stremple|first1=JohnF.|last2=Abramoff|first2=Peter|last3=Van Oss|first3=CarelJ.|last4=Wilson|first4=StuartD.|last5=Ellison|first5=EdwinH.|title=ANTIBODIES TO SYNTHETIC HUMAN GASTRIN I|journal=The Lancet|volume=290|issue=7527|year=1967|pages=1180–1182|issn=01406736|doi=10.1016/S0140-6736(67)91895-8}}</ref><ref name="McGuiganTrudeau1968">{{cite journal|last1=McGuigan|first1=James E.|last2=Trudeau|first2=Walter L.|title=Immunochemical Measurement of Elevated Levels of Gastrin in the Serum of Patients with Pancreatic Tumors of the Zollinger-Ellison Variety|journal=New England Journal of Medicine|volume=278|issue=24|year=1968|pages=1308–1313|issn=0028-4793|doi=10.1056/NEJM196806132782402}}</ref> | |||
*[[H2 blocker|Histamine-2 blocking drugs (H2)]] were introduced as the first effective medical therapy for Zollinger-Ellison syndrome in 1975.<ref name="pmid1124750">{{cite journal| author=Mainardi M, Maxwell V, Sturdevant RA, Isenberg JI| title=Inhibition of gastric acid secretion by metiamide in Zollinger-Ellison syndrome. | journal=Am J Dig Dis | year= 1975 | volume= 20 | issue= 3 | pages= 280-1 | pmid=1124750 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1124750 }}</ref> | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 21:17, 11 September 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
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Overview
In 1955, Zollinger and Ellison published their seminal paper on gastrinomas wherein the Zollinger-Ellison syndrome was discussed for the first time.
Historical Perspective
- In 1955, Zollinger and Ellison announced their concept about ulcerogenic islet cell tumor which caused marked ulcer diathesis due to gastric hyperacidity.[1]
- Dr. Robert M. Zollinger and Dr. Edwin H. Ellison announced their theory at the annual meeting of American Surgical Association in Philadelphia in April 1956.[2]
- This concept raised from clinical case of two women who presented with perforated jejunal ulcers accompanied with severe ulcer diathesis.
- One of the patients was a 36 year-old woman with past history of 8 years abdominal pain and diarrhea. A laparotomy revealed perforated jejunal ulcers with severe recurrent hemorrhage. Although she underwent two subtotal gastric resections, transabdominal vagotomy, and transthoracic vagotomy, her symptoms were constantly persistent. Finally she underwent total gastrectomy; however, she died due to anastomic leakage from the surgery. Her autopsy was in favor of non-beta pancreatic islet cell tumor.[3]
- The other patient was a 19 year-old woman with 2 years of upper abdominal pain. She underwent a surgery in July 1953 and was diagnosed with two perforated jejunal ulcers. A truncal vagotomy and a radical subtotal gastrectomy were performed in January 1954. This operation was called a dream operation for ulcers by Zollinger. Due to unsuccessful results of the operation, she had to go through radiation therapy to her stomach. Eventually, total gastrectomy was performed. The results described a non-beta islet cell carcinoma with lymph node metastasis.
- In 1956, Ben Eiseman of Denver, Colorado, presented the same experience with one of his patients and called the condition "Zollinger-Ellison syndrome".[4]
- Discovery of insulinoma in 1927 and malignant carcinoid syndrome in 1953, have exceeded the presentation and discovery of Zollinger-Ellison syndrome.[5][6]
- In the 1960s, gastrin was described to be involved in the pathogenesis of gastric hyperacidity by Dr. Lester.[7]
- Roderic Gregory and Hilda Tracy of Liverpool proved that gastrin is the cause of Zollinger-Ellison syndrome. [8]
- Radioimmunoassay was developed for assessment of gastrin level in 1967 and 1968.[9][10]
- Histamine-2 blocking drugs (H2) were introduced as the first effective medical therapy for Zollinger-Ellison syndrome in 1975.[11]
References
- ↑ Zollinger RM (1991). "[The history of the Zollinger-Ellison syndrome]". Ann Gastroenterol Hepatol (Paris). 27 (5): 223–6. PMID 1746876.
- ↑ ZOLLINGER RM, ELLISON EH (1955). "Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas". Ann Surg. 142 (4): 709–23, discussion, 724–8. PMC 1465210. PMID 13259432.
- ↑ Kaplan, Edwin L.; Tanaka, Reiko; Ito, Koichi; Younes, Nidal; Friesen, Stanley R. (1994). "The discovery of the Zollinger-Ellison syndrome". Journal of Hepato-Biliary-Pancreatic Surgery. 1 (5): 509–516. doi:10.1007/BF01211912. ISSN 0944-1166.
- ↑ Chey WY, Chang TM, Lee KY, Sun G, Kim CK, You CH; et al. (1989). "Ulcerogenic tumor syndrome of the pancreas associated with a nongastrin acid secretagogue". Ann Surg. 210 (2): 139–49. PMC 1357819. PMID 2757418.
- ↑ Wilder, Russell M.; Allan, Frank N.; Power, M. H.; Robertson, H. E. (1927). "CARCINOMA OF THE ISLANDS OF THE PANCREAS". Journal of the American Medical Association. 89 (5): 348. doi:10.1001/jama.1927.02690050014007. ISSN 0002-9955.
- ↑ Epelboym I, Mazeh H (2014). "Zollinger-Ellison syndrome: classical considerations and current controversies". Oncologist. 19 (1): 44–50. doi:10.1634/theoncologist.2013-0369. PMC 3903066. PMID 24319020.
- ↑ Hou W, Schubert ML (2006). "Gastric secretion". Curr Opin Gastroenterol. 22 (6): 593–8. doi:10.1097/01.mog.0000245538.43142.87. PMID 17053435.
- ↑ Leske JS (1985). "Hyperglycemic hyperosmolar nonketotic coma: a nursing care plan". Crit Care Nurse. 5 (5): 49–56. PMID 3851712.
- ↑ Stremple, JohnF.; Abramoff, Peter; Van Oss, CarelJ.; Wilson, StuartD.; Ellison, EdwinH. (1967). "ANTIBODIES TO SYNTHETIC HUMAN GASTRIN I". The Lancet. 290 (7527): 1180–1182. doi:10.1016/S0140-6736(67)91895-8. ISSN 0140-6736.
- ↑ McGuigan, James E.; Trudeau, Walter L. (1968). "Immunochemical Measurement of Elevated Levels of Gastrin in the Serum of Patients with Pancreatic Tumors of the Zollinger-Ellison Variety". New England Journal of Medicine. 278 (24): 1308–1313. doi:10.1056/NEJM196806132782402. ISSN 0028-4793.
- ↑ Mainardi M, Maxwell V, Sturdevant RA, Isenberg JI (1975). "Inhibition of gastric acid secretion by metiamide in Zollinger-Ellison syndrome". Am J Dig Dis. 20 (3): 280–1. PMID 1124750.