Zollinger-Ellison syndrome classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
- The World Health Organization classifies NETs into two broad categories, well differentiated and poorly differentiated, and most gastrinomas are considered well-differentiated NETs on the basis of histopathological analysis.
Classiffication
- Gastrinomas are derived from the enteroendocrine cells that arise from the embryologic endoderm, and form tumors mainly in the pancreas, but also in the proximal small intestine. Because of their origin, these are generally classified under the larger umbrella term of neuroendocrine tumors (NETs). [1]
- The World Health Organization classifies NETs into two broad categories, well differentiated and poorly differentiated, and most gastrinomas are considered well-differentiated NETs on the basis of histopathological analysis. It has been observed that most gastrinomas arise in the duodenum, with tumors located in the pancreas carrying greater malignant potential. [2]
References
- ↑ Norton JA (1994). "Neuroendocrine tumors of the pancreas and duodenum". Curr Probl Surg. 31 (2): 77–156. PMID 7904550.
- ↑ O'Toole D, Delle Fave G, Jensen RT (2012). "Gastric and duodenal neuroendocrine tumours". Best Pract Res Clin Gastroenterol. 26 (6): 719–35. doi:10.1016/j.bpg.2013.01.002. PMID 23582915.