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Patients with waldenström's macroglobulinemia should have nerve conduction study, [[antimyelin associated glycoprotein]] serology<ref name="ser" />, and fundoscopy done.<ref name="eye">Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015</ref> Bone marrow aspirate is frequently hypocellular in waldenström's macroglobulinemia. Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are characteristic feature of waldenström's macroglobulinemia.<ref name="BME">{{cite journal |vauthors=Agarwal A, Ghobrial IM |title=The bone marrow microenvironment in Waldenström macroglobulinemia |journal=Clin Lymphoma Myeloma Leuk |volume=13 |issue=2 |pages=218–21 |year=2013 |pmid=23490994 |pmc=3654400 |doi=10.1016/j.clml.2013.02.006 |url=}}</ref> | Patients with waldenström's macroglobulinemia should have nerve conduction study, [[antimyelin associated glycoprotein]] serology<ref name="ser" />, and fundoscopy done.<ref name="eye">Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015</ref> Bone marrow aspirate is frequently hypocellular in waldenström's macroglobulinemia. Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are characteristic feature of waldenström's macroglobulinemia.<ref name="BME">{{cite journal |vauthors=Agarwal A, Ghobrial IM |title=The bone marrow microenvironment in Waldenström macroglobulinemia |journal=Clin Lymphoma Myeloma Leuk |volume=13 |issue=2 |pages=218–21 |year=2013 |pmid=23490994 |pmc=3654400 |doi=10.1016/j.clml.2013.02.006 |url=}}</ref> | ||
== | ==Other Diagnostic Studies== | ||
* | Other diagnostic studies for Waldenström macroglobulinemia include: | ||
* '''Nerve conduction tests''' and '''electromyography''', which demonstrates: | |||
**[[demyelination]] with sensory involvement more than motor<ref name="ser">{{cite journal |vauthors=Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, Barbieri S, Moggio M, Polli N, Polli E, Scarlato G |title=Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins |journal=Neurology |volume=37 |issue=9 |pages=1506–14 |year=1987 |pmid=2442666 |doi= |url=}}</ref> | |||
* | * Fundoscopy, which demonstrates: | ||
**Enlarged veins in the [[retina]]<ref name="eye">Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015</ref> | |||
* | |||
*[[ | |||
: | |||
:* '''Plasma viscosity''' | :* '''Plasma viscosity''' | ||
:** Plasma viscosity should be measured in patients presenting with [[hyperviscosity syndrome]] whenever the monoclonal IgM protein spike is >4 g/dL. | :** Plasma viscosity should be measured in patients presenting with [[hyperviscosity syndrome]] whenever the monoclonal IgM protein spike is >4 g/dL. | ||
Revision as of 02:47, 31 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Patients with waldenström's macroglobulinemia should have nerve conduction study, antimyelin associated glycoprotein serology[1], and fundoscopy done.[2] Bone marrow aspirate is frequently hypocellular in waldenström's macroglobulinemia. Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are characteristic feature of waldenström's macroglobulinemia.[3]
Other Diagnostic Studies
Other diagnostic studies for Waldenström macroglobulinemia include:
- Nerve conduction tests and electromyography, which demonstrates:
- demyelination with sensory involvement more than motor[1]
- Fundoscopy, which demonstrates:
- Plasma viscosity
- Plasma viscosity should be measured in patients presenting with hyperviscosity syndrome whenever the monoclonal IgM protein spike is >4 g/dL.
- The normal plasma viscosity is 1.8 centipoise.
- Patient presents with hyperviscosity symptoms with viscosity >4 centipoise.
- Plasma viscosity
References
- ↑ 1.0 1.1 Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, Barbieri S, Moggio M, Polli N, Polli E, Scarlato G (1987). "Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins". Neurology. 37 (9): 1506–14. PMID 2442666.
- ↑ 2.0 2.1 Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015
- ↑ Agarwal A, Ghobrial IM (2013). "The bone marrow microenvironment in Waldenström macroglobulinemia". Clin Lymphoma Myeloma Leuk. 13 (2): 218–21. doi:10.1016/j.clml.2013.02.006. PMC 3654400. PMID 23490994.