Waldenström's macroglobulinemia other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Patients with waldenström's macroglobulinemia should have nerve conduction study, [[antimyelin associated glycoprotein]] serology<ref name="ser"></ref>, and fundoscopy done.<ref name="eye">Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015</ref> Bone marrow aspirate is frequently hypocellular in waldenström's macroglobulinemia. Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are characteristic feature of waldenström's macroglobulinemia.<ref name="BME">{{cite journal |vauthors=Agarwal A, Ghobrial IM |title=The bone marrow microenvironment in Waldenström macroglobulinemia |journal=Clin Lymphoma Myeloma Leuk |volume=13 |issue=2 |pages=218–21 |year=2013 |pmid=23490994 |pmc=3654400 |doi=10.1016/j.clml.2013.02.006 |url=}}</ref> | Patients with waldenström's macroglobulinemia should have nerve conduction study, [[antimyelin associated glycoprotein]] serology<ref name="ser"></ref>, and fundoscopy done.<ref name="eye">Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015</ref> Bone marrow aspirate is frequently hypocellular in waldenström's macroglobulinemia. Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are characteristic feature of waldenström's macroglobulinemia.<ref name="BME">{{cite journal |vauthors=Agarwal A, Ghobrial IM |title=The bone marrow microenvironment in Waldenström macroglobulinemia |journal=Clin Lymphoma Myeloma Leuk |volume=13 |issue=2 |pages=218–21 |year=2013 |pmid=23490994 |pmc=3654400 |doi=10.1016/j.clml.2013.02.006 |url=}}</ref> | ||
==Findings in Nerve Conduction Study== | ==Findings in Nerve Conduction Study== | ||
*Patients with waldenström's macroglobulinemia show demyelination with sensory involvement more than motor.<ref name="ser">{{cite journal |vauthors=Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, Barbieri S, Moggio M, Polli N, Polli E, Scarlato G |title=Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins |journal=Neurology |volume=37 |issue=9 |pages=1506–14 |year=1987 |pmid=2442666 |doi= |url=}}</ref> | *Patients with waldenström's macroglobulinemia show [[demyelination]] with sensory involvement more than motor.<ref name="ser">{{cite journal |vauthors=Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, Barbieri S, Moggio M, Polli N, Polli E, Scarlato G |title=Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins |journal=Neurology |volume=37 |issue=9 |pages=1506–14 |year=1987 |pmid=2442666 |doi= |url=}}</ref> | ||
==Findings in Serology== | ==Findings in Serology== | ||
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==Findings in Fundoscopy== | ==Findings in Fundoscopy== | ||
*Waldenström's macroglobulinemia may show enlarged veins in the retina.<ref name="eye">Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015</ref> | *Waldenström's macroglobulinemia may show enlarged veins in the [[retina]].<ref name="eye">Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015</ref> | ||
==Findings in Bone Marrow Aspirate== | ==Findings in Bone Marrow Aspirate== | ||
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==Findings in Bone Marrow Biopsy== | ==Findings in Bone Marrow Biopsy== | ||
*Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. | *Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. | ||
*Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are the characteristic features of waldenström's macroglobulinemia. | *[[Dutcher bodies]] (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are the characteristic features of waldenström's macroglobulinemia. | ||
*Three patterns of marrow involvement are described, as follows: | *Three patterns of marrow involvement are described, as follows: | ||
:*Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern | :*Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern | ||
Revision as of 02:20, 11 January 2016
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Waldenström's macroglobulinemia Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Patients with waldenström's macroglobulinemia should have nerve conduction study, antimyelin associated glycoprotein serology[1], and fundoscopy done.[2] Bone marrow aspirate is frequently hypocellular in waldenström's macroglobulinemia. Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are characteristic feature of waldenström's macroglobulinemia.[3]
Findings in Nerve Conduction Study
- Patients with waldenström's macroglobulinemia show demyelination with sensory involvement more than motor.[1]
Findings in Serology
- Waldenström's macroglobulinemia shows antimyelin associated glycoprotein.[1]
Findings in Fundoscopy
Findings in Bone Marrow Aspirate
- Bone marrow aspirate is frequently hypocellular.[3]
Findings in Bone Marrow Biopsy
- Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells.
- Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are the characteristic features of waldenström's macroglobulinemia.
- Three patterns of marrow involvement are described, as follows:
- Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern
- Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern
- A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures)
References
- ↑ 1.0 1.1 1.2 Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, Barbieri S, Moggio M, Polli N, Polli E, Scarlato G (1987). "Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins". Neurology. 37 (9): 1506–14. PMID 2442666.
- ↑ 2.0 2.1 Waldenström's macroglobulinemia. MedlinePlus (2015)https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 16, 2015
- ↑ 3.0 3.1 Agarwal A, Ghobrial IM (2013). "The bone marrow microenvironment in Waldenström macroglobulinemia". Clin Lymphoma Myeloma Leuk. 13 (2): 218–21. doi:10.1016/j.clml.2013.02.006. PMC 3654400. PMID 23490994.