Waldenström's macroglobulinemia laboratory findings: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 4: Line 4:


==Overview==
==Overview==
Elevated beta-2-microglobulin and abnormal coagulation studies are diagnostic of waldenström's macroglobulinemia. <ref name="Lb"> {{cite journal |vauthors=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A, Rodríguez-García JA, Massó P, Pérez-Aliaga A, Monteagudo MD, Navarro I, Moreno G, Toledo C, Alonso A, Besses C, Besalduch J, Jarque I, Salama P, Rivas JA, Navarro B, Bladé J, Miguel JF |title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases |journal=Br. J. Haematol. |volume=115 |issue=3 |pages=575–82 |year=2001 |pmid=11736938 |doi= |url=}}</ref>
Elevated beta-2-microglobulin and abnormal coagulation studies are characteristic of waldenström's macroglobulinemia. <ref name="Lb"> {{cite journal |vauthors=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A, Rodríguez-García JA, Massó P, Pérez-Aliaga A, Monteagudo MD, Navarro I, Moreno G, Toledo C, Alonso A, Besses C, Besalduch J, Jarque I, Salama P, Rivas JA, Navarro B, Bladé J, Miguel JF |title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases |journal=Br. J. Haematol. |volume=115 |issue=3 |pages=575–82 |year=2001 |pmid=11736938 |doi= |url=}}</ref>


==Laboratory Findings==
==Laboratory Findings==
Line 28: Line 28:
*[[Albumin-to-globulin ratio]]
*[[Albumin-to-globulin ratio]]
*[[Rheumatoid factor]], [[cryoglobulins]], direct anti-globulin test, and cold agglutinin titre results can be positive.  
*[[Rheumatoid factor]], [[cryoglobulins]], direct anti-globulin test, and cold agglutinin titre results can be positive.  
*Coaglulation studies can be abnormal with elevated [[prothrombin time]], [[activated partial thromboplastin time]], and [[thrombin time]].
*[[Coagulation studies]] can be abnormal with elevated [[prothrombin time]], [[activated partial thromboplastin time]], and [[thrombin time]].


===Plasma viscosity===
===Plasma viscosity===

Revision as of 00:20, 11 January 2016

Waldenström's macroglobulinemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Waldenström's macroglobulinemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Bone Marrow Aspiration and Biopsy

Electrophoresis and Immunofixation

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Waldenström's macroglobulinemia laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Waldenström's macroglobulinemia laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Waldenström's macroglobulinemia laboratory findings

CDC on Waldenström's macroglobulinemia laboratory findings

Waldenström's macroglobulinemia laboratory findings in the news

Blogs on Waldenström's macroglobulinemia laboratory findings

Directions to Hospitals Treating Waldenström's macroglobulinemia

Risk calculators and risk factors for Waldenström's macroglobulinemia laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]

Overview

Elevated beta-2-microglobulin and abnormal coagulation studies are characteristic of waldenström's macroglobulinemia. [1]

Laboratory Findings

Complete blood count

Peripheral smear

  • Plasmacytoid lymphocytes
  • Normocytic normochromic red blood cells
  • Rouleaux formation

Chemistry lab tests

  • Hypercalcemia(4%)

Plasma viscosity

  • Plasma viscosity should be measured in patients presenting with hyperviscosity syndrome whenever the monoclonal IgM protein spike is >4 g/dL.
  • The normal plasma viscosity is 1.8 centipoise.
  • Patients start presenting with hyperviscosity symptoms when viscosity >4 centipoise.

References

  1. 1.0 1.1 García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A, Rodríguez-García JA, Massó P, Pérez-Aliaga A, Monteagudo MD, Navarro I, Moreno G, Toledo C, Alonso A, Besses C, Besalduch J, Jarque I, Salama P, Rivas JA, Navarro B, Bladé J, Miguel JF (2001). "Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases". Br. J. Haematol. 115 (3): 575–82. PMID 11736938.

Template:WH Template:WS