WBR0870
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Immunology, MainCategory::Pathology |
| Sub Category | SubCategory::Pulmonology |
| Prompt | [[Prompt::A 65 year old lung transplant patient presents to the transplant clinic for several months of gradually worsening shortness of breath. He had been out of the country and was not able to see a physician until now. After proper examination, the physician orders a set of pulmonary function tests and a high resolution chest CT. The results obtained raised the suspicion of chronic transplant rejection. If the physician was to order a lung biopsy, what findings would confirm his suspicion?]] |
| Answer A | AnswerA::Bronchiolitis obliterans |
| Answer A Explanation | AnswerAExp::A form of fibrotic lung changes seen in patients with chronic lung transplant rejection. |
| Answer B | AnswerB::Vascular fibrosis |
| Answer B Explanation | AnswerBExp::Usually seen in chronic rejection of kidney and liver transplants. |
| Answer C | AnswerC::Graft vessel occlusion |
| Answer C Explanation | AnswerCExp::Usually seen in hyperacute rejection due to preformed antibodies, not in chronic rejection. |
| Answer D | AnswerD::Graft vessel vasculitis |
| Answer D Explanation | AnswerDExp::Usually seen in acute rejection, not in chronic rejection. |
| Answer E | AnswerE::Giant cell formation |
| Answer E Explanation | AnswerEExp::Not a characteristic of transplant rejection. |
| Right Answer | RightAnswer::A |
| Explanation | [[Explanation::Bronchiolitis obliterans, a manifestation of chronic transplant rejection, is a fibrotic process that leads to progressive narrowing of bronchiolar lumens with eventual airflow obstruction. It is a pattern seen on histologic examination that typically represents transplant rejection with transplant failure within 5 years of initial diagnosis. It is a form of chronic rejection similar to other organ transplants; however, it does not involve the blood vessels typically seen in chronic rejection of renal and liver transplants.
Belperio JA, Lake K, Tazelaar H, Keane MP, Strieter RM, Lynch JP. Bronchiolitis obliterans syndrome complicating lung or heart-lung transplantation. Semin Respir Crit Care Med. 2003;24(5):499-530. |
| Approved | Approved::No |
| Keyword | WBRKeyword::Chronic rejection, WBRKeyword::bronchiolitis obliterans, WBRKeyword::lung transplant |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |