WBR0738
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Physiology |
| Sub Category | SubCategory::Endocrine, SubCategory::Renal |
| Prompt | [[Prompt::A researcher is studying the effect of a new medication, MedX. He uses mice to conduct his experiments. Following the intravenous administration of MedX, the researcher notes the decreased secretion of aldosterone secondary to MedX's effect in reducing the production of a compound from the pulmonary vasculature. Based on the image below, which of the following reactions is most likely the first to be inhibited upon administration of MedX?
|
| Answer A | AnswerA::A |
| Answer A Explanation | AnswerAExp::Angiotensinogen is formed by the liver. It is converted to angiotensin I by renin. Renin is formed by the juxtraglomerular cells of the kidney. |
| Answer B | AnswerB::B |
| Answer B Explanation | AnswerBExp::Angiotensin-converting enzyme (ACE) is found in the pulmonary vasculature. It normally converts angiotensin I to angiotensin II. |
| Answer C | AnswerC::C |
| Answer C Explanation | AnswerCExp::ACE does not act at the level of the angiotensin receptor. |
| Answer D | AnswerD::D |
| Answer D Explanation | AnswerDExp::ACE does not act at the level of the angiotensin receptor. |
| Answer E | AnswerE::E |
| Answer E Explanation | AnswerEExp::ACE does not act at the level beyond the activation of the receptor. |
| Right Answer | RightAnswer::B |
| Explanation | [[Explanation::The effects of MedX are similar to angiotensin-converting enzyme (ACE) inhibitors. ACE is an enzyme that is produced by the pulmonary vasculature and is responsible for the conversion of angiotensin I to angiotensin II. The inhibition of the ACE leads to the inhibition of the entire renin-angiotensin pathway and the reduced production of aldosterone.
Educational Objective: ACE is an enzyme produced by the pulmonary vasculature. It normally converts angiotensin I to angiotensin II. |
| Approved | Approved::No |
| Keyword | WBRKeyword::angiotensin, WBRKeyword::converting, WBRKeyword::enzyme, WBRKeyword::ACE, WBRKeyword::inhibitor, WBRKeyword::angiotensinogen, WBRKeyword::renin, WBRKeyword::pulmonary, WBRKeyword::vasculature, WBRKeyword::vessel, WBRKeyword::vessels, WBRKeyword::hormone, WBRKeyword::conversion, WBRKeyword::convert, WBRKeyword::angiotensin I, WBRKeyword::angiotensin II, WBRKeyword::angiotensin 1, WBRKeyword::angiotensin 2, WBRKeyword::aldosterone |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |
