WBR0660
| Author | [[PageAuthor::Serge Korjian M.D. (Reviewed by Serge Korjian)]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Biostatistics/Epidemiology |
| Sub Category | SubCategory::Gastrointestinal |
| Prompt | [[Prompt::A new vaccine is being developed for the prevention of Hepatitis E. In a phase 2 clinical trial, 100 individuals are randomized to receive either the vaccine or a placebo. Out of the 50 patients that received the vaccine 1 went on to develop Hepatitis E in the 6 month follow up after the vaccination. In the placebo group 7 out of 50 patients developed Hepatitis. What is the number needed to treat for this newly developed vaccine according to the results of this trial?]] |
| Answer A | AnswerA::0.14 |
| Answer A Explanation | AnswerAExp::0.14 is not the number needed to treat |
| Answer B | AnswerB::7.14 |
| Answer B Explanation | AnswerBExp::7.14 is not the number needed to treat |
| Answer C | AnswerC::8.33 |
| Answer C Explanation | AnswerCExp::The number needed to treat in this trial is 8.33 |
| Answer D | AnswerD::300 |
| Answer D Explanation | AnswerDExp::300 is not the number needed to treat |
| Answer E | AnswerE::Data insufficient to calculate |
| Answer E Explanation | AnswerEExp::Given the equation below, all variables are available to calculate the number needed to treat. |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation::The number needed to treat refers to the number of patients required to receive a certain treatment for 1 patient to benefit from it. It is usually the inverse of the absolute risk reduction(ARR). The ARR can be calculated as follows:
|
| Approved | Approved::Yes |
| Keyword | WBRKeyword::Number needed to treat, WBRKeyword::Absolute risk reduction |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |
