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{{WBRQuestion
{{WBRQuestion
|QuestionAuthor=Anonymous {{Alison}}
|QuestionAuthor={{Rim}}
|ExamType=USMLE Step 1
|ExamType=USMLE Step 1
|MainCategory=Pathophysiology
|MainCategory=Pathophysiology
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|MainCategory=Pathophysiology
|MainCategory=Pathophysiology
|SubCategory=Gastrointestinal
|SubCategory=Gastrointestinal
|MainCategory=Pathophysiology
|MainCategory=Pathophysiology
|MainCategory=Pathophysiology
|MainCategory=Pathophysiology
|MainCategory=Pathophysiology
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|MainCategory=Pathophysiology
|MainCategory=Pathophysiology
|SubCategory=Gastrointestinal
|SubCategory=Gastrointestinal
|Prompt=A 32 year old woman presents to the emergency department for 3 hours of severe right upper quadrant abdominal pain. The patient reports that her crisis started shortly after a lunch of chicken nuggets and french fries. On physical exam, you note marked tenderness to palpation, and when the patient is asked to breath in while her liver is being palpated she cuts her breath short because of her pain. Abdominal ultrasound is unremarkable. Magnetic resonance cholangiogram reveals air in the biliary tree but no evidence of stone. What would you expect the patient to complain of other than her pain?
|Explanation=The patient has the typical presentation of a biliary colic with physical exam suggestive of cholecystitis (Murphy's sign is positive). The air seen in the biliary tree is indicative that a large gallbladder stone has probably created a fistula between the gallbladder and the small intestine allowing it to escape. Classically, if the stone is large enough, it would obstruct the narrowest part of the intestinal lumen, usually the ileocecal valve. Obstruction would cause a syndrome of ileus with bloating, nausea and vomiting, and obstipation known as gallstone ileus.




|Prompt=An obese, multiparous, 48-year-old female presents to the physician's office with a nonradiating right upper quadrant abdominal pain with bloating, nausea, and vomiting that worsens after the consumption of fries and a hamburger. Abdominal ultrasonography displays hyperechogenic foci within the thickened gallbladder wall. Laboratory testing reveals a WBC count of 16,000/μL and serum amylase and lipase levels of 75 U/L and 150 U/L, respectively. Which of the following secreted substances most likely accounts for her abdominal pain?
Learning objective: Large biliary stones can create a fistula between the gallbladder and duodenum and block the ileocecal valve leading to gallstone ileus.
 


|Explanation=The patient in this scenario demonstrates classic findings of acute [[gallstone|calculous]] [[cholecystitis]]. Acute [[gallstone|calculous]] [[cholecystitis]] typically develops in patients who fit the profile of the '''4F's: <u>F</u>emale, <u>F</u>at, <u>F</u>ertile, and in her <u>F</u>orties'''. Strenuous contraction of the [[gallbladder]], described as a nonradiating abdominal pain in the right upper quadrant, is secondary to the effect of [[cholecystokinin]], which is secreted in response to ingestion of lipids and proteins.


[[File:GI hormones.png|800px]]
Reference:


|AnswerA=Cholecystokinin
Le T, Bhushan V. First Aid for the USMLE Step 1 2014. McGraw-Hill Medical; 2014.
|AnswerAExp=See overall explanation
|AnswerA=Bloody diarrhea
|AnswerB=Gastrin
|AnswerAExp=Bloddy diarrhea is not usually seen with gallstones that perforate.
|AnswerBExp=See overall explanation
|AnswerB=Fever, chills and abdominal rigidity
|AnswerC=Pepsin
|AnswerBExp=Fever, chills and abdominal rigidity can sometimes be seen in severe ascending cholangitis with continued obstruction.
|AnswerCExp=See overall explanation
|AnswerC=Bloating, vomiting, and obstipation
|AnswerD=Secretin
|AnswerCExp=Bloating, vomiting, and obstipation are characteristic of gallstone ileus.
|AnswerDExp=See overall explanation
|AnswerD=Jaundice and icterus
|AnswerE=Gastric inhibitory peptide
|AnswerDExp=Jaundice and icterus are seen in active biliary tract obstruction absent in this patient.
|AnswerEExp=See overall explanation
|AnswerE=Shortness of breath
|EducationalObjectives= Acute [[gallstone|calculous]] [[cholecystitis]] typically develops in patients who fit the profile of the '''4F's (<u>F</u>emale, <u>F</u>at, <u>F</u>ertile, and in her <u>F</u>orties'''). It is often manifested as a nonradiating right upper quadrant pain due to strenuous contraction of the gallbladder induced by [[cholecystokinin]].
|AnswerEExp=Shortness of breath is not typical of large perforating stones.
|References=Le T, Bhushan V. First Aid for the USMLE Step 1 2014. McGraw-Hill Medical; 2014.
|RightAnswer=C
|RightAnswer=A
|WBRKeyword=Gallstone ileus, Cholelithiasis, Cholecystitis
|WBRKeyword=Cholelithiasis, Cholecystitis, Cholecystokinin
|Approved=No
|Approved=No
}}
}}

Revision as of 20:20, 5 January 2015

 
Author [[PageAuthor::Rim Halaby, M.D. [1]]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Pathophysiology
Sub Category SubCategory::Gastrointestinal
Prompt [[Prompt::A 32 year old woman presents to the emergency department for 3 hours of severe right upper quadrant abdominal pain. The patient reports that her crisis started shortly after a lunch of chicken nuggets and french fries. On physical exam, you note marked tenderness to palpation, and when the patient is asked to breath in while her liver is being palpated she cuts her breath short because of her pain. Abdominal ultrasound is unremarkable. Magnetic resonance cholangiogram reveals air in the biliary tree but no evidence of stone. What would you expect the patient to complain of other than her pain?]]
Answer A AnswerA::Bloody diarrhea
Answer A Explanation AnswerAExp::Bloddy diarrhea is not usually seen with gallstones that perforate.
Answer B AnswerB::Fever, chills and abdominal rigidity
Answer B Explanation AnswerBExp::Fever, chills and abdominal rigidity can sometimes be seen in severe ascending cholangitis with continued obstruction.
Answer C AnswerC::Bloating, vomiting, and obstipation
Answer C Explanation AnswerCExp::Bloating, vomiting, and obstipation are characteristic of gallstone ileus.
Answer D AnswerD::Jaundice and icterus
Answer D Explanation AnswerDExp::Jaundice and icterus are seen in active biliary tract obstruction absent in this patient.
Answer E AnswerE::Shortness of breath
Answer E Explanation AnswerEExp::Shortness of breath is not typical of large perforating stones.
Right Answer RightAnswer::C
Explanation [[Explanation::The patient has the typical presentation of a biliary colic with physical exam suggestive of cholecystitis (Murphy's sign is positive). The air seen in the biliary tree is indicative that a large gallbladder stone has probably created a fistula between the gallbladder and the small intestine allowing it to escape. Classically, if the stone is large enough, it would obstruct the narrowest part of the intestinal lumen, usually the ileocecal valve. Obstruction would cause a syndrome of ileus with bloating, nausea and vomiting, and obstipation known as gallstone ileus.


Learning objective: Large biliary stones can create a fistula between the gallbladder and duodenum and block the ileocecal valve leading to gallstone ileus.


Reference:

Le T, Bhushan V. First Aid for the USMLE Step 1 2014. McGraw-Hill Medical; 2014.
Educational Objective:
References: ]]

Approved Approved::No
Keyword WBRKeyword::Gallstone ileus, WBRKeyword::Cholelithiasis, WBRKeyword::Cholecystitis
Linked Question Linked::
Order in Linked Questions LinkedOrder::