WBR0465

Author	[[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by Alison Leibowitz)]]
Exam Type	ExamType::USMLE Step 1
Main Category	MainCategory::Microbiology
Sub Category	SubCategory::Genitourinary
Prompt	[[Prompt::A 60-year-old female presents to the physician’s office with post-coital bleeding. Upon appropriate work-up, the patient's pathology findings are illustrated below. You explain to the patient that her condition is most likely a sexually transmitted virus. Which of the following characteristics best describes the virus implicated in this patient's pathology? ]]
Answer A	AnswerA::Double-stranded, non-enveloped DNA virus
Answer A Explanation	AnswerAExp::The human papilloma virus (HPV) is a double-stranded, non-enveloped DNA virus.
Answer B	AnswerB::Double-stranded, enveloped DNA virus
Answer B Explanation	AnswerBExp::HPV is a non-enveloped virus.
Answer C	AnswerC::Single-stranded, non-enveloped DNA virus
Answer C Explanation	AnswerCExp::HPV is a double-stranded virus.
Answer D	AnswerD::Single-stranded, enveloped RNA virus.
Answer D Explanation	AnswerDExp::HPV is a double-stranded, non-enveloped DNA virus.
Answer E	AnswerE::Double-stranded, non-enveloped RNA virus
Answer E Explanation	AnswerEExp::HPV is a DNA virus.
Right Answer	RightAnswer::A
Explanation	[[Explanation::The patient presents with an abnormal pap-smear that displays the presence of koilocytes, abnormal cells infected by the human papilloma virus (HPV). The image illustrated above depicts a normal cervical cell on the left, and a koilocyte on the right side, which contains a characteristic large nuclei with a perinuclear halo. HPV is a sexually transmitted infection (STI). The virus is a double-stranded, non-envolved DNA virus. Among the most significant HPV types are HPV type 16, 18, 31, 33, and 45, which predispose to cervical cancer, and 6, 11, 42, 43, and 44 which frequently result in genital warts. Educational Objective: Koilocytes, with characteristic enlarged nuclei with perinuclear halos, are cells infected with HPV. HPV is a sexually transmitted virus manifesting in over 100 forms, some of which predispose to cervical cancer and others to genital warts. References: First Aid 2014 page 158]]
Approved	Approved::Yes
Keyword	WBRKeyword::double stranded, WBRKeyword::DNA, WBRKeyword::non-enveloped, WBRKeyword::HPV, WBRKeyword::human papilloma virus, WBRKeyword::genital warts, WBRKeyword::cervical cancer, WBRKeyword::sexually transmitted, WBRKeyword::gentiles
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Order in Linked Questions	LinkedOrder::