WBR0401

Author	[[PageAuthor::Serge Korjian, M.D. (Reviewed by Serge Korjian)]]
Exam Type	ExamType::USMLE Step 1
Main Category	MainCategory::Pharmacology
Sub Category	SubCategory::Cardiology, SubCategory::Vascular
Prompt	[[Prompt::The mechanism of action of a novel experimental drug is under investigation. The drug is intended to treat patients with atrial and ventricular arrhythmias who cannot tolerate other therapies. After initial rat testing, the core lab determines that the active molecule acts on the transmembrane proteins that regulate the resting membrane potential of cardiomyocytes. ECG monitoring demonstrates significant, dose-dependent increase in the QT interval in treated rats. Which of the following drugs is likely to be related to the experimental drug being evaluated?]]
Answer A	AnswerA::Sotalol
Answer A Explanation	AnswerAExp::
Answer B	AnswerB::Procainamide
Answer B Explanation	AnswerBExp::
Answer C	AnswerC::Propafenone
Answer C Explanation	AnswerCExp::
Answer D	AnswerD::Metoprolol
Answer D Explanation	AnswerDExp::
Answer E	AnswerE::Mexiletine
Answer E Explanation	AnswerEExp::
Right Answer	RightAnswer::A
Explanation	[[Explanation:: Educational Objective: References: Tamargo J, Caballero R, Gómez R, Valenzuela C, Delpón E. Pharmacology of cardiac potassium channels. Cardiovasc Res. 2004;62(1):9-33.]]
Approved	Approved::Yes
Keyword
Linked Question	Linked::
Order in Linked Questions	LinkedOrder::