WBR0142: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
Line 1: Line 1:
{{WBRQuestion
{{WBRQuestion
|QuestionAuthor={{Rim}}
|QuestionAuthor={{Rim}} (Reviewed by William J Gibson)
|ExamType=USMLE Step 1
|ExamType=USMLE Step 1
|MainCategory=Pathology
|MainCategory=Pathology
Line 8: Line 8:
|MainCategory=Pathology
|MainCategory=Pathology
|SubCategory=Endocrine
|SubCategory=Endocrine
|MainCategory=Pathology
|MainCategory=Pathology
|MainCategory=Pathology
|MainCategory=Pathology
|MainCategory=Pathology
Line 20: Line 21:
|MainCategory=Pathology
|MainCategory=Pathology
|SubCategory=Endocrine
|SubCategory=Endocrine
|Prompt=A 27 year old previously healthy female patient presents to her primary care physician for generalized fatigue and difficulty concentrating that have started since almost three months.  The review of system of this patient reveals hair loss, dry skin, constipation and cold intolerance.  Blood test for [[antimicrosomal antibody|antithyroid peroxidase antibodies]] is positive.  This patient’s medical condition increases her risk of developing which of the following malignancies?
|Prompt=A previously healthy 27-year-old female patient presents to her primary care physician for generalized fatigue and difficulty concentrating for the past three months.  She reports hair loss, dry skin, constipation and cold intolerance.  Serology for [[antimicrosomal antibody|antithyroid peroxidase antibodies]] is positive.  This patient’s condition increases her risk of developing which of the following malignancies?
|Explanation=The patient is suffering from fatigue, constipation, cold intolerance and decreased concentration which are all suggestive of hypothyroidism.  The diagnosis of hypothyroidism was further confirmed by the positive laboratory test for [[antimicrosomal antibody|antithyroid peroxidase antibodies]]. [[Hashimoto's thyroiditis]] is associated with increased risk of thyroid [[lymphoma]].
|Explanation=This patient is suffering from fatigue, constipation, cold intolerance and decreased concentration which are all suggestive of hypothyroidism.  The diagnosis of hypothyroidism was further confirmed by the positive laboratory test for [[antimicrosomal antibody|antithyroid peroxidase antibodies]]. [[Hashimoto's thyroiditis]] is associated with increased risk of thyroid [[lymphoma]].


Educational objective: [[Hashimoto's thyroiditis]] is considered a risk factor for the development of thyroid [[lymphoma]].
Educational objective: [[Hashimoto's thyroiditis]] is considered a risk factor for the development of thyroid [[lymphoma]].
Line 34: Line 35:
|AnswerE=Anaplastic carcinoma of the thyroid
|AnswerE=Anaplastic carcinoma of the thyroid
|AnswerEExp=This patient has Hashimoto’s disease.  It does not increase the risk of developing anaplastic carcinoma of the thyroid.
|AnswerEExp=This patient has Hashimoto’s disease.  It does not increase the risk of developing anaplastic carcinoma of the thyroid.
|EducationalObjectives=Hashimoto's thyroiditis is associated with
|RightAnswer=D
|RightAnswer=D
|Approved=No
|WBRKeyword=Autoimmune, Thyroid, Thyroiditis, Cancer, Hashimoto's thryoiditis, Endocrinology
|Approved=Yes
}}
}}

Revision as of 15:22, 12 July 2014
Author [[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by William J Gibson)]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Pathology
Sub Category SubCategory::Endocrine
Prompt [[Prompt::A previously healthy 27-year-old female patient presents to her primary care physician for generalized fatigue and difficulty concentrating for the past three months. She reports hair loss, dry skin, constipation and cold intolerance. Serology for antithyroid peroxidase antibodies is positive. This patient’s condition increases her risk of developing which of the following malignancies?]]
Answer A AnswerA::Papillary carcinoma of the thyroid
Answer A Explanation AnswerAExp::This patient has Hashimoto’s disease. It does not increase the risk of developing papillary carcinoma of the thyroid.
Answer B AnswerB::Follicular carcinoma of the thyroid
Answer B Explanation AnswerBExp::This patient has Hashimoto’s disease. It does not increase the risk of developing follicular carcinoma of the thyroid.
Answer C AnswerC::Medullary carcinoma of the thyroid
Answer C Explanation [[AnswerCExp::This patient has Hashimoto’s disease. It does not increase the risk of developing medullary carcinoma of the thyroid.]]
Answer D AnswerD::Lymphoma of the thyroid
Answer D Explanation [[AnswerDExp::Thyroid lymphoma affects predominantly females over 70 years of age with a history of Hashimoto's thyroiditis. Thus, Hashimoto's thyroiditis is considered as risk factor for the development of thyroid lymphoma. The thyroid lymphoma manifests as rapidly enlarging neck mass causing respiratory difficulty. On physical examination, patients usually exhibit a firm thyroid and lymphadenopathy.]]
Answer E AnswerE::Anaplastic carcinoma of the thyroid
Answer E Explanation AnswerEExp::This patient has Hashimoto’s disease. It does not increase the risk of developing anaplastic carcinoma of the thyroid.
Right Answer RightAnswer::D
Explanation [[Explanation::This patient is suffering from fatigue, constipation, cold intolerance and decreased concentration which are all suggestive of hypothyroidism. The diagnosis of hypothyroidism was further confirmed by the positive laboratory test for antithyroid peroxidase antibodies. Hashimoto's thyroiditis is associated with increased risk of thyroid lymphoma.

Educational objective: Hashimoto's thyroiditis is considered a risk factor for the development of thyroid lymphoma.
Educational Objective: Hashimoto's thyroiditis is associated with
References: ]]

Approved Approved::Yes
Keyword WBRKeyword::Autoimmune, WBRKeyword::Thyroid, WBRKeyword::Thyroiditis, WBRKeyword::Cancer, WBRKeyword::Hashimoto's thryoiditis, WBRKeyword::Endocrinology
Linked Question Linked::
Order in Linked Questions LinkedOrder::
Retrieved from "https://www.wikidoc.org/index.php?title=WBR0142&oldid=992221"