Venereal disease research laboratory (VDRL) test

Revision as of 17:20, 20 August 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +))
Jump to navigation Jump to search

WikiDoc Resources for Venereal disease research laboratory (VDRL) test

Articles

Most recent articles on Venereal disease research laboratory (VDRL) test

Most cited articles on Venereal disease research laboratory (VDRL) test

Review articles on Venereal disease research laboratory (VDRL) test

Articles on Venereal disease research laboratory (VDRL) test in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Venereal disease research laboratory (VDRL) test

Images of Venereal disease research laboratory (VDRL) test

Photos of Venereal disease research laboratory (VDRL) test

Podcasts & MP3s on Venereal disease research laboratory (VDRL) test

Videos on Venereal disease research laboratory (VDRL) test

Evidence Based Medicine

Cochrane Collaboration on Venereal disease research laboratory (VDRL) test

Bandolier on Venereal disease research laboratory (VDRL) test

TRIP on Venereal disease research laboratory (VDRL) test

Clinical Trials

Ongoing Trials on Venereal disease research laboratory (VDRL) test at Clinical Trials.gov

Trial results on Venereal disease research laboratory (VDRL) test

Clinical Trials on Venereal disease research laboratory (VDRL) test at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Venereal disease research laboratory (VDRL) test

NICE Guidance on Venereal disease research laboratory (VDRL) test

NHS PRODIGY Guidance

FDA on Venereal disease research laboratory (VDRL) test

CDC on Venereal disease research laboratory (VDRL) test

Books

Books on Venereal disease research laboratory (VDRL) test

News

Venereal disease research laboratory (VDRL) test in the news

Be alerted to news on Venereal disease research laboratory (VDRL) test

News trends on Venereal disease research laboratory (VDRL) test

Commentary

Blogs on Venereal disease research laboratory (VDRL) test

Definitions

Definitions of Venereal disease research laboratory (VDRL) test

Patient Resources / Community

Patient resources on Venereal disease research laboratory (VDRL) test

Discussion groups on Venereal disease research laboratory (VDRL) test

Patient Handouts on Venereal disease research laboratory (VDRL) test

Directions to Hospitals Treating Venereal disease research laboratory (VDRL) test

Risk calculators and risk factors for Venereal disease research laboratory (VDRL) test

Healthcare Provider Resources

Symptoms of Venereal disease research laboratory (VDRL) test

Causes & Risk Factors for Venereal disease research laboratory (VDRL) test

Diagnostic studies for Venereal disease research laboratory (VDRL) test

Treatment of Venereal disease research laboratory (VDRL) test

Continuing Medical Education (CME)

CME Programs on Venereal disease research laboratory (VDRL) test

International

Venereal disease research laboratory (VDRL) test en Espanol

Venereal disease research laboratory (VDRL) test en Francais

Business

Venereal disease research laboratory (VDRL) test in the Marketplace

Patents on Venereal disease research laboratory (VDRL) test

Experimental / Informatics

List of terms related to Venereal disease research laboratory (VDRL) test

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The Venereal Disease Research Laboratory test (VDRL) is a nontreponemal serological screening for syphilis, the monitoring of the response to therapy, the detection of CNS involvement, and as an aid in the diagnosis of congenital syphilis. The basis of the test is that an antibody produced by a patient with syphilis reacts with an extract of ox heart (diphosphatidyl glycerol). It therefore detects anti-cardiolipin antibodies (IgG, IgM or IgA). Many other conditions can produce false positive results, including some viruses (mononucleosis, hepatitis), drugs, rheumatic fever, rheumatoid arthritis, lupus, and leprosy. The syphilis anti-cardiolipin antibodies are beta-2 glycoprotein independent,[1] where as those that occur in the antiphospholipid antibody syndrome (associated to lupus for example) are beta-2 glycoprotein dependent, and this can be used to tell them apart in an ELISA assay.[2] This test is very useful as the trend of titres are correlated to disease activity (i.e. falling titres indicate successful treatment). It has a very good sensitivity for syphilis, except in late tertiary form.

FTA-ABS is a far more specific test for syphilis and, in the presence of a positive VDRL test, indicates active infection.

Related chapters

References

  1. Hunt JE, McNeil HP, Morgan GJ, Crameri RM, Krilis SA (1992). "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but not with infection". Lupus. 1 (2): 75–81. PMID 1301967.
  2. Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus anticoagulant in patients with recurrent pregnancy loss". Journal of postgraduate medicine. 48 (1): 5–10. PMID 12082318.

Template:Autoantibodies


Template:WH Template:WikiDoc Sources