Tumor lysis syndrome primary prevention: Difference between revisions

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==Overview==
==Overview==
Effective measures for the primary prevention of tumor lysis syndrome include [[allopurinol]], [[rasburicase]], and IV hydration.
Effective measures for the primary prevention of tumor lysis syndrome include [[allopurinol]], [[rasburicase]], and [[intravenous]] hydration.
 
==Prevention==
==Prevention==
Before initiating chemotherapy for cancer patients, especially lymphomas and leukemias, should receive the following:
Before initiating chemotherapy for cancer patients, especially lymphomas and leukemias, patients should receive the following:<ref name="JonesWill2015">{{cite journal|last1=Jones|first1=Gail L|last2=Will|first2=Andrew|last3=Jackson|first3=Graham H|last4=Webb|first4=Nicholas J A|last5=Rule|first5=Simon|title=Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology|journal=British Journal of Haematology|volume=169|issue=5|year=2015|pages=661–671|issn=00071048|doi=10.1111/bjh.13403}}</ref>
 
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Patient population}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Treatment}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
Low risk
| style="padding: 5px 5px; background: #F5F5F5;" |
*Adequate [[intravenous]] hydration to maintain a high urine output (> 2.5 L/day)
*Alkalinization of urine is not recommended.<ref name="pmid9607427">{{cite journal| author=Ten Harkel AD, Kist-Van Holthe JE, Van Weel M, Van der Vorst MM| title=Alkalinization and the tumor lysis syndrome. | journal=Med Pediatr Oncol | year= 1998 | volume= 31 | issue= 1 | pages= 27-8 | pmid=9607427 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9607427  }} </ref>
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
Intermediate risk
| style="padding: 5px 5px; background: #F5F5F5;" |
*[[Allopurinol]]
*[[Allopurinol]]
*[[Rasburicase]] (uricase) is an alternative to allopurinol and is reserved for patients who are high-risk in developing TLS
:*Adults dosing: 200-400mg/m2/day in 1-3 divided doses; maximum dose is 800mg/day
*Adequate IV hydration to maintain a high urine output (> 2.5 L/day)
:*Infants weighing less than 10kg: 3.3mg/kg every 8 hours
*Alkalinization of the urine with [[acetazolamide]] or [[sodium bicarbonate]] is controversial
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
High risk
| style="padding: 5px 5px; background: #F5F5F5;" |
*[[Rasburicase]]
:*0.2mg/kg for 5-7 days
:*A single dose of 3 mg may be used in high risk patients
:*Contraindicated in patients with glucose 6 phosphate dehydrogenase ([[G6PD]]) deficiency
|-
|
|}


==References==
==References==
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[[Category:Blood]]
[[Category:Blood]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]

Latest revision as of 17:27, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Effective measures for the primary prevention of tumor lysis syndrome include allopurinol, rasburicase, and intravenous hydration.

Prevention

Before initiating chemotherapy for cancer patients, especially lymphomas and leukemias, patients should receive the following:[1]

Patient population Treatment

Low risk

  • Adequate intravenous hydration to maintain a high urine output (> 2.5 L/day)
  • Alkalinization of urine is not recommended.[2]

Intermediate risk

  • Adults dosing: 200-400mg/m2/day in 1-3 divided doses; maximum dose is 800mg/day
  • Infants weighing less than 10kg: 3.3mg/kg every 8 hours

High risk

  • 0.2mg/kg for 5-7 days
  • A single dose of 3 mg may be used in high risk patients
  • Contraindicated in patients with glucose 6 phosphate dehydrogenase (G6PD) deficiency

References

  1. Jones, Gail L; Will, Andrew; Jackson, Graham H; Webb, Nicholas J A; Rule, Simon (2015). "Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology". British Journal of Haematology. 169 (5): 661–671. doi:10.1111/bjh.13403. ISSN 0007-1048.
  2. Ten Harkel AD, Kist-Van Holthe JE, Van Weel M, Van der Vorst MM (1998). "Alkalinization and the tumor lysis syndrome". Med Pediatr Oncol. 31 (1): 27–8. PMID 9607427.

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