Transitional cell carcinoma classification: Difference between revisions

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Revision as of 15:03, 12 February 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Classification

Based on the growth pattern, transitional cell tumors may be classified into two subtypes:


Type	Description

Papillary urothelial carcinoma	Have slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity
Flat urothelial carcinomas	Lay flat in the lining of the renal pelvis and ureter They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity

WHO Classification

The World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) published a consensus opinion classification system for urothelial (transitional cell) tumors:^[1]

Transitional cell tumors

Infiltrating urothelial carcinoma

with squamous differentiation
with glandular differentiation
with trophoblastic differentiation
Nested
Microcystic
Micropapillary
Lymphoepithelioma-like
Lymphoma-like
Plasmacytoid
Sarcomatoid
Giant cell
Undifferentiated

Non-invasive urothelial carcinoma

Urothelial carcinoma in situ
High grade papillary urothelial carcinoma
Low grade papillary urothelial carcinoma
Non-invasive papillary urothelial neoplasm of low malignant potential
Urothelial papilloma
Inverted urothelial papilloma

Grading

According to the WHO grading criteria, there are three grades of transitional cell carcinoma based on the degree of cellular differentiation:


Grade	Description

Low grade	Tumors with the least degree of cellular anaplasia compatible with a diagnosis of malignancy
High grade	Tumors with the most severe degrees of cellular anaplasia

References

↑ Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F (2002). "Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems". J Clin Pathol. 55 (12): 900–5. PMC 1769816. PMID 12461053.

Template:WH Template:WS

[pmid12461053-1] Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F (2002). "Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems". J Clin Pathol. 55 (12): 900–5. PMC 1769816. PMID 12461053.

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 ===Grading===
-According to the WHO grading criteria, there are three grades of transitional cell carcinoma based on the degree of cellular differentiation:<ref name="Grignon2009">{{cite journal|last1=Grignon|first1=David J|title=The current classification of urothelial neoplasms|journal=Modern Pathology|volume=22|year=2009|pages=S60–S69|issn=0893-3952|doi=10.1038/modpathol.2008.235}}</ref>
+According to the WHO grading criteria, there are three grades of transitional cell carcinoma based on the degree of cellular differentiation:
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 *Tumors with the least degree of cellular anaplasia compatible with a diagnosis of malignancy
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-Grade 2
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-*Histologic features between grades 1 and 3
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-Grade 3
 | style="padding: 5px 5px; background: #F5F5F5;" align=left |
 *Tumors with the most severe degrees of cellular anaplasia