Transitional cell carcinoma classification: Difference between revisions

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:*Urothelial papilloma
:*Urothelial papilloma
:*Inverted urothelial papilloma
:*Inverted urothelial papilloma
===Grading===
According to the WHO grading criteria, there are three grades of transitional cell carcinoma based on the degree of cellular differentiation:<ref name="Grignon2009">{{cite journal|last1=Grignon|first1=David J|title=The current classification of urothelial neoplasms|journal=Modern Pathology|volume=22|year=2009|pages=S60–S69|issn=0893-3952|doi=10.1038/modpathol.2008.235}}</ref>
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Grade'''}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Description'''}}
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Grade 1
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*Tumors with the least degree of cellular anaplasia compatible with a diagnosis of malignancy
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; align=left" |
Grade 2
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*Histologic features between grades 1 and 3
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Grade 3
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*Tumors with the most severe degrees of cellular anaplasia
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==References==
==References==

Revision as of 20:53, 11 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Classification

In the United States, bladder cancers usually start from the cells lining the bladder (called transitional cells).

These tumors are classified based on the way they grow:

  • Papillary tumors have a wart-like appearance and are attached to a stalk.
  • Nonpapillary (sessile) tumors are much less common. However, they are more invasive and have a worse outcome.


  • Infiltrating urothelial carcinoma
  • with squamous differentiation
  • with glandular differentiation
  • with trophoblastic differentiation
  • Nested
  • Microcystic
  • Micropapillary
  • Lymphoepithelioma-like
  • Lymphoma-like
  • Plasmacytoid
  • Sarcomatoid
  • Giant cell
  • Undifferentiated
  • Non-invasive urothelial neoplasias
  • Urothelial carcinoma in situ
  • Non-invasive papillary urothelial carcinoma, high grade
  • Non-invasive papillary urothelial carcinoma, low grade
  • Non-invasive papillary urothelial neoplasm of low
  • Malignant potential
  • Urothelial papilloma
  • Inverted urothelial papilloma

Grading

According to the WHO grading criteria, there are three grades of transitional cell carcinoma based on the degree of cellular differentiation:[1]

Grade Description

Grade 1

  • Tumors with the least degree of cellular anaplasia compatible with a diagnosis of malignancy

Grade 2

  • Histologic features between grades 1 and 3

Grade 3

  • Tumors with the most severe degrees of cellular anaplasia

References

  1. Grignon, David J (2009). "The current classification of urothelial neoplasms". Modern Pathology. 22: S60–S69. doi:10.1038/modpathol.2008.235. ISSN 0893-3952.

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