TOP1

Topoisomerase (DNA) I
File:PBB Protein TOP1 image.jpg PDB rendering based on 1a31.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1a31​, 1a35​, 1a36​, 1ej9​, 1k4s​, 1k4t​, 1lpq​, 1nh3​, 1r49​, 1rr8​, 1rrj​, 1sc7​, 1seu​, 1t8i​, 1tl8​
Identifiers
Symbols	TOP1 ; TOPI
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2467
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Topoisomerase (DNA) I, also known as TOP1, is a human gene.

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

See also

• Type I topoisomerase
• Topoisomerase

Further reading

• Friedberg EC (1996). "Relationships between DNA repair and transcription". Annu. Rev. Biochem. 65: 15–42. doi:10.1146/annurev.bi.65.070196.000311. PMID 8811173.
• Leppard JB, Champoux JJ (2005). "Human DNA topoisomerase I: relaxation, roles, and damage control". Chromosoma. 114 (2): 75–85. doi:10.1007/s00412-005-0345-5. PMID 15830206.