TLE3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Transducin-like enhancer protein 3''' is a [[protein]] that in humans is encoded by the ''TLE3'' [[gene]].<ref name="pmid8365415">{{cite journal | vauthors = Miyasaka H, Choudhury BK, Hou EW, Li SS | title = Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein | journal = European Journal of Biochemistry / FEBS | volume = 216 | issue = 1 | pages = 343–52 | date = Aug 1993 | pmid = 8365415 | pmc =  | doi = 10.1111/j.1432-1033.1993.tb18151.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7090| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = PBB_Protein_TLE3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gxr.
| PDB = {{PDB2|1gxr}}, {{PDB2|2ce8}}, {{PDB2|2ce9}}
| Name = Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
| HGNCid = 11839
| Symbol = TLE3
| AltSymbols =; ESG; ESG3; FLJ39460; GRG3; HsT18976; KIAA1547
| OMIM = 600190
| ECnumber = 
| Homologene = 21059
| MGIid = 104634
| GeneAtlas_image1 = PBB_GE_TLE3_206472_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TLE3_212769_at_tn.png
| GeneAtlas_image3 = PBB_GE_TLE3_212770_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7090
    | Hs_Ensembl = ENSG00000140332
    | Hs_RefseqProtein = NP_005069
    | Hs_RefseqmRNA = NM_005078
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 68129473
    | Hs_GenLoc_end = 68176212
    | Hs_Uniprot = Q04726
    | Mm_EntrezGene = 21887
    | Mm_Ensembl = ENSMUSG00000032280
    | Mm_RefseqmRNA = XM_001003585
    | Mm_RefseqProtein = XP_001003585
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 61170864
    | Mm_GenLoc_end = 61216487
    | Mm_Uniprot = Q3TY99
  }}
}}
'''Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)''', also known as '''TLE3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7090| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S | title = Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins | journal = Nature Genetics | volume = 2 | issue = 2 | pages = 119–27 | date = Oct 1992 | pmid = 1303260 | doi = 10.1038/ng1092-119 }}
| citations =
* {{cite journal | vauthors = Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S | title = Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia | journal = Genomics | volume = 31 | issue = 1 | pages = 58–64 | date = Jan 1996 | pmid = 8808280 | doi = 10.1006/geno.1996.0009 }}
*{{cite journal | author=Stifani S, Blaumueller CM, Redhead NJ, ''et al.'' |title=Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. |journal=Nat. Genet. |volume=2 |issue= 2 |pages= 119-27 |year= 1993 |pmid= 1303260 |doi= 10.1038/ng1092-119 }}
* {{cite journal | vauthors = Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK | title = Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18418–23 | date = Jun 2000 | pmid = 10748198 | doi = 10.1074/jbc.M910211199 }}
*{{cite journal | author=Miyasaka H, Choudhury BK, Hou EW, Li SS |title=Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. |journal=Eur. J. Biochem. |volume=216 |issue= 1 |pages= 343-52 |year= 1993 |pmid= 8365415 |doi=  }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 4 | pages = 273–81 | date = Aug 2000 | pmid = 10997877 | doi = 10.1093/dnares/7.4.271 }}
*{{cite journal  | author=Liu Y, Dehni G, Purcell KJ, ''et al.'' |title=Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. |journal=Genomics |volume=31 |issue= 1 |pages= 58-64 |year= 1996 |pmid= 8808280 |doi= 10.1006/geno.1996.0009 }}
* {{cite journal | vauthors = Yao J, Lai E, Stifani S | title = The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription | journal = Molecular and Cellular Biology | volume = 21 | issue = 6 | pages = 1962–72 | date = Mar 2001 | pmid = 11238932 | pmc = 86788 | doi = 10.1128/MCB.21.6.1962-1972.2001 }}
*{{cite journal | author=Wang JC, Waltner-Law M, Yamada K, ''et al.'' |title=Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18418-23 |year= 2000 |pmid= 10748198 |doi= 10.1074/jbc.M910211199 }}
* {{cite journal | vauthors = Nuthall HN, Joachim K, Palaparti A, Stifani S | title = A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 52 | pages = 51049–57 | date = Dec 2002 | pmid = 12397081 | doi = 10.1074/jbc.M111660200 }}
*{{cite journal | author=Nagase T, Kikuno R, Nakayama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273-81 |year= 2001 |pmid= 10997877 |doi= }}
* {{cite journal | vauthors = López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P | title = Six3 and Six6 activity is modulated by members of the groucho family | journal = Development | volume = 130 | issue = 1 | pages = 185–95 | date = Jan 2003 | pmid = 12441302 | doi = 10.1242/dev.00185 }}
*{{cite journal | author=Yao J, Lai E, Stifani S |title=The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 1962-72 |year= 2001 |pmid= 11238932 |doi= 10.1128/MCB.21.6.1962-1972.2001 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Nuthall HN, Joachim K, Palaparti A, Stifani S |title=A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 51049-57 |year= 2003 |pmid= 12397081 |doi= 10.1074/jbc.M111660200 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=López-Ríos J, Tessmar K, Loosli F, ''et al.'' |title=Six3 and Six6 activity is modulated by members of the groucho family. |journal=Development |volume=130 |issue= 1 |pages= 185-95 |year= 2003 |pmid= 12441302 |doi=  }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tu LC, Yan X, Hood L, Lin B | title = Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 4 | pages = 575–88 | date = Apr 2007 | pmid = 17220478 | doi = 10.1074/mcp.M600249-MCP200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. |journal=Mol. Cell Proteomics |volume=6 |issue= 4 |pages= 575-88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7090}}


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Latest revision as of 02:19, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.[1][2]

References

  1. ↑ Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry / FEBS. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
  2. ↑ "Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=TLE3&oldid=1416947"