TCL1A: Difference between revisions

Jump to navigation Jump to search
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''T-cell leukemia/lymphoma protein 1A''' is a [[protein]] that in humans is encoded by the ''TCL1A'' [[gene]].<ref name="pmid2783489">{{cite journal | vauthors = Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM | title = Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient | journal = Proc Natl Acad Sci U S A | volume = 86 | issue = 2 | pages = 602–6 | date = February 1989 | pmid = 2783489 | pmc = 286520 | doi = 10.1073/pnas.86.2.602 }}</ref><ref name="pmid7809072">{{cite journal | vauthors = Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G | title = Identification of the TCL1 gene involved in T-cell malignancies | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 26 | pages = 12530–4 | date = February 1995 | pmid = 7809072 | pmc = 45472 | doi = 10.1073/pnas.91.26.12530 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8115| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_TCL1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jsg.
| PDB = {{PDB2|1jsg}}
| Name = T-cell leukemia/lymphoma 1A
| HGNCid = 11648
| Symbol = TCL1A
| AltSymbols =; TCL1
| OMIM = 186960
| ECnumber = 
| Homologene = 7565
| MGIid = 1097166
| GeneAtlas_image1 = PBB_GE_TCL1A_39318_at_tn.png
| GeneAtlas_image2 = PBB_GE_TCL1A_209995_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005938 |text = cell cortex}} {{GNF_GO|id=GO:0045120 |text = pronucleus}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8115
    | Hs_Ensembl = ENSG00000100721
    | Hs_RefseqProtein = NP_068801
    | Hs_RefseqmRNA = NM_021966
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 95246058
    | Hs_GenLoc_end = 95250201
    | Hs_Uniprot = P56279
    | Mm_EntrezGene = 21432
    | Mm_Ensembl = ENSMUSG00000041359
    | Mm_RefseqmRNA = NM_009337
    | Mm_RefseqProtein = NP_033363
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 105617803
    | Mm_GenLoc_end = 105623764
    | Mm_Uniprot = P56280
  }}
}}
'''T-cell leukemia/lymphoma 1A''', also known as '''TCL1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8115| accessdate = }}</ref> It is encoding a [[TCL GTPase]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
TCL1A has been shown to [[Protein-protein interaction|interact]] with [[AKT1]]<ref name=pmid11707444>{{cite journal | vauthors = Laine J, Künstle G, Obata T, Noguchi M | title = Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3743–51 | date = February 2002 | pmid = 11707444 | doi = 10.1074/jbc.M107069200 }}</ref><ref name=pmid10983986>{{cite journal | vauthors = Laine J, Künstle G, Obata T, Sha M, Noguchi M | title = The protooncogene TCL1 is an Akt kinase coactivator | journal = Mol. Cell | volume = 6 | issue = 2 | pages = 395–407 | date = August 2000 | pmid = 10983986 | doi = 10.1016/S1097-2765(00)00039-3 }}</ref><ref name=pmid12009899>{{cite journal | vauthors = French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA | title = A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6376–82 | date = May 2002 | pmid = 12009899 | doi = 10.1021/bi016068o }}</ref> and [[AKT2]].<ref name=pmid11707444/><ref name=pmid10983986/>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Pekarsky Y, Hallas C, Croce CM | title = The role of TCL1 in human T-cell leukemia | journal = Oncogene | volume = 20 | issue = 40 | pages = 5638–43 | year = 2001 | pmid = 11607815 | doi = 10.1038/sj.onc.1204596 }}
| citations =
* {{cite journal | vauthors = Pekarsky Y, Zanesi N, Aqeilan R, Croce CM | title = Tcl1 as a model for lymphomagenesis | journal = Hematol. Oncol. Clin. North Am. | volume = 18 | issue = 4 | pages = 863–79, ix | year = 2004 | pmid = 15325703 | doi = 10.1016/j.hoc.2004.04.007 }}
*{{cite journal | author=Pekarsky Y, Hallas C, Croce CM |title=The role of TCL1 in human T-cell leukemia. |journal=Oncogene |volume=20 |issue= 40 |pages= 5638-43 |year= 2001 |pmid= 11607815 |doi= 10.1038/sj.onc.1204596 }}
* {{cite journal | vauthors = Noguchi M, Ropars V, Roumestand C, Suizu F | title = Proto-oncogene TCL1: more than just a coactivator for Akt | journal = FASEB J. | volume = 21 | issue = 10 | pages = 2273–84 | year = 2007 | pmid = 17360849 | doi = 10.1096/fj.06-7684com }}
*{{cite journal | author=Pekarsky Y, Zanesi N, Aqeilan R, Croce CM |title=Tcl1 as a model for lymphomagenesis. |journal=Hematol. Oncol. Clin. North Am. |volume=18 |issue= 4 |pages= 863-79, ix |year= 2004 |pmid= 15325703 |doi= 10.1016/j.hoc.2004.04.007 }}
* {{cite journal | vauthors = Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM | title = Characterization and localization of the TCL-1 oncogene product | journal = Cancer Res. | volume = 54 | issue = 24 | pages = 6297–301 | year = 1995 | pmid = 7987816 | doi =  }}
*{{cite journal | author=Noguchi M, Ropars V, Roumestand C, Suizu F |title=Proto-oncogene TCL1: more than just a coactivator for Akt. |journal=FASEB J. |volume=21 |issue= 10 |pages= 2273-84 |year= 2007 |pmid= 17360849 |doi= 10.1096/fj.06-7684com }}
* {{cite journal | vauthors = Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H | title = Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology | journal = Structure | volume = 6 | issue = 2 | pages = 147–55 | year = 1998 | pmid = 9519406 | doi = 10.1016/S0969-2126(98)00017-3 }}
*{{cite journal | author=Russo G, Isobe M, Gatti R, ''et al.'' |title=Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 2 |pages= 602-6 |year= 1989 |pmid= 2783489 |doi=  }}
* {{cite journal | vauthors = Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, Aizawa Y, Ueda R, Seto M | title = Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia | journal = Jpn. J. Cancer Res. | volume = 89 | issue = 7 | pages = 712–8 | year = 1998 | pmid = 9738977 | doi = 10.1111/j.1349-7006.1998.tb03275.x }}
*{{cite journal  | author=Virgilio L, Narducci MG, Isobe M, ''et al.'' |title=Identification of the TCL1 gene involved in T-cell malignancies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12530-4 |year= 1995 |pmid= 7809072 |doi=  }}
* {{cite journal | vauthors = Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM | title = Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 6 | pages = 2949–51 | year = 1999 | pmid = 10077617 | pmc = 15875 | doi = 10.1073/pnas.96.6.2949 }}
*{{cite journal  | author=Fu TB, Virgilio L, Narducci MG, ''et al.'' |title=Characterization and localization of the TCL-1 oncogene product. |journal=Cancer Res. |volume=54 |issue= 24 |pages= 6297-301 |year= 1995 |pmid= 7987816 |doi=  }}
* {{cite journal | vauthors = Laine J, Künstle G, Obata T, Sha M, Noguchi M | title = The protooncogene TCL1 is an Akt kinase coactivator | journal = Mol. Cell | volume = 6 | issue = 2 | pages = 395–407 | year = 2000 | pmid = 10983986 | doi = 10.1016/S1097-2765(00)00039-3 }}
*{{cite journal | author=Hoh F, Yang YS, Guignard L, ''et al.'' |title=Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. |journal=Structure |volume=6 |issue= 2 |pages= 147-55 |year= 1998 |pmid= 9519406 |doi= }}
* {{cite journal | vauthors = Laine J, Künstle G, Obata T, Noguchi M | title = Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3743–51 | year = 2002 | pmid = 11707444 | doi = 10.1074/jbc.M107069200 }}
*{{cite journal | author=Takizawa J, Suzuki R, Kuroda H, ''et al.'' |title=Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. |journal=Jpn. J. Cancer Res. |volume=89 |issue= 7 |pages= 712-8 |year= 1998 |pmid= 9738977 |doi= }}
* {{cite journal | vauthors = French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA | title = A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6376–82 | year = 2002 | pmid = 12009899 | doi = 10.1021/bi016068o }}
*{{cite journal | author=Pekarsky Y, Hallas C, Isobe M, ''et al.'' |title=Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 2949-51 |year= 1999 |pmid= 10077617 |doi= }}
* {{cite journal | vauthors = Fears S, Chakrabarti SR, Nucifora G, Rowley JD | title = Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression | journal = Cancer Genet. Cytogenet. | volume = 135 | issue = 2 | pages = 110–9 | year = 2002 | pmid = 12127395 | doi = 10.1016/S0165-4608(01)00655-0 }}
*{{cite journal | author=Laine J, Künstle G, Obata T, ''et al.'' |title=The protooncogene TCL1 is an Akt kinase coactivator. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 395-407 |year= 2000 |pmid= 10983986 |doi= }}
* {{cite journal | vauthors = Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA | title = Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 22 | pages = 14392–7 | year = 2002 | pmid = 12381789 | pmc = 137894 | doi = 10.1073/pnas.212410199 }}
*{{cite journal | author=Laine J, Künstle G, Obata T, Noguchi M |title=Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3743-51 |year= 2002 |pmid= 11707444 |doi= 10.1074/jbc.M107069200 }}
* {{cite journal | vauthors = French SW, Malone CS, Shen RR, Renard M, Henson SE, Miner MD, Wall R, Teitell MA | title = Sp1 transactivation of the TCL1 oncogene | journal = J. Biol. Chem. | volume = 278 | issue = 2 | pages = 948–55 | year = 2003 | pmid = 12421830 | doi = 10.1074/jbc.M207166200 }}
*{{cite journal | author=French SW, Shen RR, Koh PJ, ''et al.'' |title=A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane. |journal=Biochemistry |volume=41 |issue= 20 |pages= 6376-82 |year= 2002 |pmid= 12009899 |doi= }}
* {{cite journal | vauthors = Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D | title = TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin | journal = Blood | volume = 101 | issue = 12 | pages = 5007–9 | year = 2004 | pmid = 12576313 | doi = 10.1182/blood-2002-10-3297 }}
*{{cite journal | author=Fears S, Chakrabarti SR, Nucifora G, Rowley JD |title=Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. |journal=Cancer Genet. Cytogenet. |volume=135 |issue= 2 |pages= 110-9 |year= 2002 |pmid= 12127395 |doi= }}
* {{cite journal | vauthors = Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L | title = T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4813–8 | year = 2003 | pmid = 12672960 | pmc = 153638 | doi = 10.1073/pnas.0730710100 }}
*{{cite journal | author=Hoyer KK, French SW, Turner DE, ''et al.'' |title=Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 22 |pages= 14392-7 |year= 2002 |pmid= 12381789 |doi= 10.1073/pnas.212410199 }}
*{{cite journal | author=French SW, Malone CS, Shen RR, ''et al.'' |title=Sp1 transactivation of the TCL1 oncogene. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 948-55 |year= 2003 |pmid= 12421830 |doi= 10.1074/jbc.M207166200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Herling M, Teitell MA, Shen RR, ''et al.'' |title=TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. |journal=Blood |volume=101 |issue= 12 |pages= 5007-9 |year= 2004 |pmid= 12576313 |doi= 10.1182/blood-2002-10-3297 }}
*{{cite journal | author=Kiss C, Nishikawa J, Takada K, ''et al.'' |title=T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4813-8 |year= 2003 |pmid= 12672960 |doi= 10.1073/pnas.0730710100 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8115}}
{{WikiDoc Sources}}
 
 
{{gene-14-stub}}

Latest revision as of 11:42, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.[1][2][3]

Interactions

TCL1A has been shown to interact with AKT1[4][5][6] and AKT2.[4][5]

References

  1. Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.
  2. Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.
  3. "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".
  4. 4.0 4.1 Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
  5. 5.0 5.1 Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
  6. French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

Further reading