Sinusoidal obstruction syndrome risk factors: Difference between revisions
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Common risk factors in the development of sinusoidal obstruction syndrome are stem cell transplantation, preexisting liver dysfunction and high-dose conditioning regimens. | Common risk factors in the development of sinusoidal obstruction syndrome are stem cell transplantation, preexisting liver dysfunction and high-dose conditioning regimens. | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors for sinusoidal obstruction syndrome are:<ref name="pmid12744547">{{cite journal| author=Kumar S, DeLeve LD, Kamath PS, Tefferi A| title=Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. | journal=Mayo Clin Proc | year= 2003 | volume= 78 | issue= 5 | pages= 589-98 | pmid=12744547 | doi=10.4065/78.5.589 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12744547 }} </ref><ref name="pmid8420443">{{cite journal |vauthors=McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA |title=Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients |journal=Ann. Intern. Med. |volume=118 |issue=4 |pages=255–67 |year=1993 |pmid=8420443 |doi= |url=}}</ref> | Common risk factors for sinusoidal obstruction syndrome are:<ref name="pmid12744547">{{cite journal| author=Kumar S, DeLeve LD, Kamath PS, Tefferi A| title=Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. | journal=Mayo Clin Proc | year= 2003 | volume= 78 | issue= 5 | pages= 589-98 | pmid=12744547 | doi=10.4065/78.5.589 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12744547 }} </ref><ref name="pmid8420443">{{cite journal |vauthors=McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA |title=Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients |journal=Ann. Intern. Med. |volume=118 |issue=4 |pages=255–67 |year=1993 |pmid=8420443 |doi= |url=}}</ref><ref name="pmid9808553">{{cite journal |vauthors=Carreras E, Bertz H, Arcese W, Vernant JP, Tomás JF, Hagglund H, Bandini G, Esperou H, Russell J, de la Rubia J, Di Girolamo G, Demuynck H, Hartmann O, Clausen J, Ruutu T, Leblond V, Iriondo A, Bosi A, Ben-Bassat I, Koza V, Gratwohl A, Apperley JF |title=Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party |journal=Blood |volume=92 |issue=10 |pages=3599–604 |year=1998 |pmid=9808553 |doi= |url=}}</ref> | ||
*Stem cell transplantation | *Stem cell transplantation | ||
*Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation) | *Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation) | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Common risk factors in the development of sinusoidal obstruction syndrome are stem cell transplantation, preexisting liver dysfunction and high-dose conditioning regimens.
Risk Factors
Common risk factors for sinusoidal obstruction syndrome are:[1][2][3]
- Stem cell transplantation
- Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation)
- Presence of hepatic metastases
- Advanced age
- Prior radiation treatment of the liver
- High-dose conditioning regimens
- Allogeneic transplantation (compared with autologous transplantation)
References
- ↑ Kumar S, DeLeve LD, Kamath PS, Tefferi A (2003). "Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation". Mayo Clin Proc. 78 (5): 589–98. doi:10.4065/78.5.589. PMID 12744547.
- ↑ McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). "Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients". Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.
- ↑ Carreras E, Bertz H, Arcese W, Vernant JP, Tomás JF, Hagglund H, Bandini G, Esperou H, Russell J, de la Rubia J, Di Girolamo G, Demuynck H, Hartmann O, Clausen J, Ruutu T, Leblond V, Iriondo A, Bosi A, Ben-Bassat I, Koza V, Gratwohl A, Apperley JF (1998). "Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party". Blood. 92 (10): 3599–604. PMID 9808553.