Sinusoidal obstruction syndrome pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathogenesis== | ==Pathogenesis== | ||
Pathogenesis is the mechanism by which a certain factor causes disease (''pathos'' = disease, ''genesis'' = development). The term can also be used to describe the development of the disease, whether it is acute, chronic, or recurrent. It can also be used to describe whether the disease causes inflammation, malignancy, necrosis etc. | Pathogenesis is the mechanism by which a certain factor causes disease (''pathos'' = disease, ''genesis'' = development). The term can also be used to describe the development of the disease, whether it is acute, chronic, or recurrent. It can also be used to describe whether the disease causes inflammation, malignancy, necrosis etc. | ||
Revision as of 14:28, 26 December 2017
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Sinusoidal obstruction syndrome Microchapters |
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Differentiating Sinusoidal obstruction syndrome from Other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Sinusoidal obstruction syndrome pathophysiology On the Web |
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American Roentgen Ray Society Images of Sinusoidal obstruction syndrome pathophysiology |
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Directions to Hospitals Treating Sinusoidal obstruction syndrome |
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Risk calculators and risk factors for Sinusoidal obstruction syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathogenesis
Pathogenesis is the mechanism by which a certain factor causes disease (pathos = disease, genesis = development). The term can also be used to describe the development of the disease, whether it is acute, chronic, or recurrent. It can also be used to describe whether the disease causes inflammation, malignancy, necrosis etc.
Template Sentences
IF the pathogenesis of the disease is unclear:
- The exact pathogenesis of [disease name] is not fully understood.
- It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
IF the disease is infectious…
- …and the route of transmission is known:
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
IF the disease has a known genetic component:
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
IF certain pathology findings are characteristic of the disease:
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Other relevant information may include the action of the pathogen on a molecular level, the body’s response, whether or not mutations play a role in the disease development, whether the pathophysiology of the disease is different among subgroups of the disease, etc. Additional template sentences are listed below. Due to the highly variable nature of pathophysiology among various diseases, this list is not comprehensive.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The development of [disease name] is the result of multiple genetic mutations.
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.
- For an example of a pathogenesis section within a pathophysiology page, click here
Genetics
- Some diseases are genetic, and have particular inheritance patterns, and express different phenotypes.
- The effect that genetics may have on the pathophysiology of a disease can be described in this section.
Template sentences
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
Associated Conditions
- Conditions associated with the disease can be detailed in this section.
Template sentences
- The most important conditions/diseases associated with [disease name] include:
- Condition 1: A brief explanation of the condition and its association with the disease
- Condition 2: A brief explanation of the condition and its association with the disease
For an example of an associated conditions sub-section of pathophysiology, click here.
Gross Pathology
- Gross pathology refers to macroscopic or larger scale manifestations of disease in organs, tissues and body cavities. The term is commonly used by pathologist to refer to diagnostically useful findings made during the gross examination portion of surgical specimen processing or an autopsy.
Template Sentences
- Template Sentences 1: On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
- Template Sentence 2: The most important characteristics of [disease name] on gross pathology are:
- Organ 1: List of characteristics + image
- Organ 2: List of characteristics + image
- Organ 3: List of characteristics + image
- This section is a good place to include pictures. Search for copyleft images on The Pathology Wiki [2] and Ask Dr. Wiki [3].
- For an example of this section, click here.
Microscopic Pathology
- Microscopic pathology is the disease process as it occurs at the microscopic level.
- Template Sentence 1: On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
- Template Sentence 2: The most important histopathological characteristics of [disease name] are summarized in the table below:
| Organs | Light microscope | Electron microscope | Images |
|---|---|---|---|
| Organ 1 | Characteristic 1a | Characterstic 1b | Image 1 |
| Organ 2 | Characteristic 2a | Characterstic 2b | Image 2 |
| Organ 3 | Characterstic 3a | Characterstic 3b | Image 3 |
- This section is a good place to include pictures. Search for copyleft images on The Pathology Wiki [4] and Ask Dr. Wiki [5].
- For an example of this section, click here.