Sinusoidal obstruction syndrome classification: Difference between revisions

Jump to navigation Jump to search
 
(8 intermediate revisions by one other user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Sinusoidal obstruction syndrome}}
{{Sinusoidal obstruction syndrome}}
{{CMG}}; {{AE}}
{{CMG}}; {{AE}} {{HS}}


==Overview==
==Overview==
There is no established system for the classification of sinusoidal obstruction syndrome.
There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.


==Classification==
==Classification==
There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and sever.  
There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.<ref name="pmid24833355">{{cite journal |vauthors=Chao N |title=How I treat sinusoidal obstruction syndrome |journal=Blood |volume=123 |issue=26 |pages=4023–6 |year=2014 |pmid=24833355 |doi=10.1182/blood-2014-03-551630 |url=}}</ref>


{| class="wikitable"
{| class="wikitable"
Line 15: Line 15:
! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" + |Severe
! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" + |Severe
|-
|-
| align="center" style="background:#DCDCDC;" + |Serum total bilirubin
| align="center" style="background:#DCDCDC;" + |Serum [[Bilirubin|total bilirubin]]
|
|
* <5 mg/dL
* <5 mg/dL
Line 23: Line 23:
* >8 mg/dL
* >8 mg/dL
|-
|-
| align="center" style="background:#DCDCDC;" + |Serum aspartate aminotransferase (AST)  
| align="center" style="background:#DCDCDC;" + |[[AST|Serum aspartate aminotransferase (AST)]]
|
|
* <3 x normal
* <3 x normal
|
* 3 to 8 x normal
|
|
* >8 x normal
* >8 x normal
|
* 3 to 8 x normal
|-
|-
| colspan="1" rowspan="1" align="center" style="background:#DCDCDC;" + |[[Anion gap|Weight above baseline]]
| colspan="1" rowspan="1" align="center" style="background:#DCDCDC;" + |[[Anion gap|Weight above baseline]]
| colspan="1" rowspan="1" |
| colspan="1" rowspan="1" |
* (Na<sup>+</sup>) – (Cl<sup>–</sup> + HCO3<sup>–</sup>)
* <2 percent
| colspan="1" rowspan="1" |
| colspan="1" rowspan="1" |
* 7 to 13 (mEq/L)
* 2 to 5 percent
|
|
* Variable
* >5 percent
|-
|-
| colspan="1" rowspan="1" align="center" style="background:#DCDCDC;" + |[[Osmolality|Serum creatinine]]
| colspan="1" rowspan="1" align="center" style="background:#DCDCDC;" + |[[Osmolality|Serum creatinine]]
| colspan="1" rowspan="1" |
| colspan="1" rowspan="1" |
* 2([[Sodium|Na]] + [[Potassium|K]]) + ([[glucose]]/18) + ([[blood]] [[urea]] [[nitrogen]]/2.8)
* Normal
| colspan="1" rowspan="1" |
| colspan="1" rowspan="1" |
* 285 to 295 mOsm/kg (285 to 295 mmol/kg) of water
* <2 x normal
|
|
* Increased (> 320mOsm/kg)
* >2 x normal
|-
|Rate of change
|Slow (over 6–7 d)
|(over 4–5 d)
|Rapid (over2–3 d)
|}
|}



Latest revision as of 15:23, 28 February 2018

Sinusoidal obstruction syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sinusoidal obstruction syndrome from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Sinusoidal obstruction syndrome classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Sinusoidal obstruction syndrome classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Sinusoidal obstruction syndrome classification

CDC on Sinusoidal obstruction syndrome classification

Sinusoidal obstruction syndrome classification in the news

Blogs on Sinusoidal obstruction syndrome classification

Directions to Hospitals Treating Sinusoidal obstruction syndrome

Risk calculators and risk factors for Sinusoidal obstruction syndrome classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]

Overview

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.

Classification

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.[1]

Parameters Mild Moderate Severe
Serum total bilirubin
  • <5 mg/dL
  • < (5.1 to 8 mg/dL
  • >8 mg/dL
Serum aspartate aminotransferase (AST)
  • <3 x normal
  • 3 to 8 x normal
  • >8 x normal
Weight above baseline
  • <2 percent
  • 2 to 5 percent
  • >5 percent
Serum creatinine
  • Normal
  • <2 x normal
  • >2 x normal
Rate of change Slow (over 6–7 d) (over 4–5 d) Rapid (over2–3 d)

References

  1. Chao N (2014). "How I treat sinusoidal obstruction syndrome". Blood. 123 (26): 4023–6. doi:10.1182/blood-2014-03-551630. PMID 24833355.

Template:WS Template:WH