Seizure primary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]


Some of the preventable etiologies for epilepsy that should be considered in primary prevention include central nervous system (CNS) infection, CNS parasitosis, prenatal and perinatal brain insults, stroke, and traumatic brain injury (TBI). Some factors that can precipitate or provoke seizure may include chronic sleep deprivation, alcohol use, illicit drug use, some medications that reduce the seizure threshold, toxins, homeostasis abnormalities due to organ failure, metabolic abnormalities, and medical and surgical histories that may be important in assessing the patient’s risk for future seizures.

Primary Prevention

Some of the preventable etiologies for epilepsy that should be considered in primary prevention include:[1]

Factors that can precipitate or provoke seizure may include:[2][3][4]


  1. Thurman DJ, Begley CE, Carpio A, Helmers S, Hesdorffer DC, Mu J; et al. (2018). "The primary prevention of epilepsy: A report of the Prevention Task Force of the International League Against Epilepsy". Epilepsia. 59 (5): 905–914. doi:10.1111/epi.14068. PMC 7004820 Check |pmc= value (help). PMID 29637551.
  2. Pohlmann-Eden, Bernd; Legg, Karen T. (2013). "Treatment of first seizure in adults: A comprehensive approach integrating 10 key principles". Epileptology. Elsevier BV. 1 (1): 61–67. doi:10.1016/j.epilep.2013.01.005. ISSN 2212-8220.
  3. Delanty N, Vaughan CJ, French JA (1998). "Medical causes of seizures". Lancet. 352 (9125): 383–90. doi:10.1016/S0140-6736(98)02158-8. PMID 9717943.
  4. Gavvala JR, Schuele SU (2016). "New-Onset Seizure in Adults and Adolescents: A Review". JAMA. 316 (24): 2657–2668. doi:10.1001/jama.2016.18625. PMID 28027373.