Sandbox sowminya

B-cell neoplasms

CD5+

CD5-

CCND1+

CCND1-

DLBCL

Pleomorphic MCL

DLBCL, NOS CD5+

CD10+

CD10-

DLBCL, NOS GCB type

BCL6+ IRF4/MUM1-

BCL6+ IRF4/MUM1+

BCL6- IRF4/MUM1+

DLBCL, NOS GCB type

Non-GCB

Post-GCB

Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Neoplasms

B-cell neoplasms

CD5+

CD5-

CCND1+

CCND1-

DLBCL

Pleomorphic MCL

DLBCL, NOS CD5+

CD10+

CD10-

DLBCL, NOS GCB type

BCL6+ IRF4/MUM1-

BCL6+ IRF4/MUM1+

BCL6- IRF4/MUM1+

DLBCL, NOS GCB type

Non-GCB

Post-GCB

Revised staging system for primary nodal lymphomas (Lugano classification)

Stage	Chemotherapy	Radiotherapy	Stem cell transplant
I & II
I	(ABVD) Adriamycin AND Bleomycin AND Vinblastine AND Dacarbazine	External beam radiation therapy may be offered
II	(ABVD) Adriamycin AND Bleomycin AND Vinblastine AND Dacarbazine	External beam radiation therapy may be offered
III & IV
III	(MOPP) Mechlorethamine AND Oncovin AND Prednisone AND Procarbazine (ABVD) Adriamycin AND Bleomycin AND Vinblastine AND Dacarbazine (Stanford V) Adriamycin AND Bleomycin AND Vinblastine AND Vincristine AND Mechlorethamine AND Etoposide AND Prednisone (BEACOPP) Bleomycin AND Etoposide AND Adriamycin AND Cyclophosphamide AND Oncovin AND Procarbazine AND Prednisone	External beam radiation therapy may be offered
IV	(MOPP) Mechlorethamine AND Oncovin AND Prednisone AND Procarbazine (ABVD) Adriamycin AND Bleomycin AND Vinblastine AND Dacarbazine (Stanford V) Adriamycin AND Bleomycin AND Vinblastine AND Vincristine AND Mechlorethamine AND Etoposide AND Prednisone (BEACOPP) Bleomycin AND Etoposide AND Adriamycin AND Cyclophosphamide AND Oncovin AND Procarbazine AND Prednisone
Recurrent disease
Recurrence	(MOPP) Mechlorethamine AND Oncovin AND Prednisone AND Procarbazine (ABVD) Adriamycin AND Bleomycin AND Vinblastine AND Dacarbazine (Stanford V) Adriamycin AND Bleomycin AND Vinblastine AND Vincristine AND Mechlorethamine AND Etoposide AND Prednisone (BEACOPP) Bleomycin AND Etoposide AND Adriamycin AND Cyclophosphamide AND Oncovin AND Procarbazine AND Prednisone (GDP)Gemcitabine AND Dexamethasone AND Cisplatin (CBV) Cyclophosphamide AND Carmustine AND Etoposide (BEAM) Carmustine AND Etoposide AND Cytarabine AND Melphalan	External beam radiation therapy may be offered	Stem cell transplant may be offered