Sandbox sowminya: Difference between revisions
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{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | |||
|+ '''Revised staging system for primary nodal lymphomas (Lugano classification)''' | |||
! style="background: #4479BA; color:#FFF;" | Type of cell | |||
! style="background: #4479BA; color:#FFF;" | Characteristics | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''Classic''' | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Reed-Sternberg cells (RSC) | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Large size (20–50 micrometres), abundant, amphophilic, finely granular/homogeneous [[cytoplasm]]; two mirror-image [[nuclei]] (owl eyes) each with an eosinophilic nucleolus and a thick [[nuclear membrane]] ([[chromatin]] is distributed close to the nuclear membrane). | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''Variants''' | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Hodgkin cell | |||
| style="padding: 5px 5px; background: #F5F5F5;" | (Atypical mononuclear Reed-Sternberg cell) has the same characteristics as Reed-Sternberg cells (RSC), but is mononucleated. | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Lacunar Reed-Sternberg cells | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Are large, with a single hyperlobulated nucleus, multiple, small nucleoli and eosinophilic cytoplasm which is retracted around the nucleus, creating an empty space ("lacunae"). | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Pleomorphic Reed-Sternberg cells | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Has multiple irregular nuclei. | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | "Popcorn" Reed-Sternberg cells | |||
| style="padding: 5px 5px; background: #F5F5F5;" | (Lympho-histiocytic variant) is a small cell, with a very lobulated nucleus, small nucleoli. | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | "Mummy" Reed-Sternberg cells | |||
| style="padding: 5px 5px; background: #F5F5F5;" | has a compact nucleus with no nucleolus and basophilic cytoplasm. | |||
|} | |||
Revision as of 19:08, 4 September 2015
| B-cell neoplasms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CD5+ | CD5- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCND1+ | CCND1- | DLBCL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pleomorphic MCL | DLBCL, NOS CD5+ | CD10+ | CD10- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BCL6+ IRF4/MUM1- | BCL6+ IRF4/MUM1+ | BCL6- IRF4/MUM1+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | Non-GCB | Post-GCB | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Neoplasms
| B-cell neoplasms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CD5+ | CD5- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCND1+ | CCND1- | DLBCL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pleomorphic MCL | DLBCL, NOS CD5+ | CD10+ | CD10- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BCL6+ IRF4/MUM1- | BCL6+ IRF4/MUM1+ | BCL6- IRF4/MUM1+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | Non-GCB | Post-GCB | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type of cell | Characteristics | |
|---|---|---|
| Classic | ||
| Reed-Sternberg cells (RSC) | Large size (20–50 micrometres), abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane (chromatin is distributed close to the nuclear membrane). | |
| Variants | ||
| Hodgkin cell | (Atypical mononuclear Reed-Sternberg cell) has the same characteristics as Reed-Sternberg cells (RSC), but is mononucleated. | |
| Lacunar Reed-Sternberg cells | Are large, with a single hyperlobulated nucleus, multiple, small nucleoli and eosinophilic cytoplasm which is retracted around the nucleus, creating an empty space ("lacunae"). | |
| Pleomorphic Reed-Sternberg cells | Has multiple irregular nuclei. | |
| "Popcorn" Reed-Sternberg cells | (Lympho-histiocytic variant) is a small cell, with a very lobulated nucleus, small nucleoli. | |
| "Mummy" Reed-Sternberg cells | has a compact nucleus with no nucleolus and basophilic cytoplasm. | |