Sandbox sowminya: Difference between revisions
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| style="padding: 5px 5px; background: #FFEFD5;" | Mixed-cellularity subtype | | style="padding: 5px 5px; background: #FFEFD5;" | Mixed-cellularity subtype | ||
| style="padding: 5px 5px; background: #FFEFD5;" | | | style="padding: 5px 5px; background: #FFEFD5;" | Common subtype and is composed of numerous classic Reed-Sternberg cells admixed with numerous inflammatory cells including lymphocytes, [[histiocytes]], eosinophils, and plasma cells without sclerosis. This type is most often associated with Epstein–Barr virus (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #FFEFD5;" | Lymphocyte-rich | | style="padding: 5px 5px; background: #FFEFD5;" | Lymphocyte-rich | ||
| style="padding: 5px 5px; background: #FFEFD5;" | | | style="padding: 5px 5px; background: #FFEFD5;" | Rare subtype, show many features which may cause diagnostic confusion with nodular lymphocyte predominant B-cell [[Non-Hodgkin's Lymphoma]] (B-NHL). This form also has the most favorable prognosis. | ||
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| style="padding: 5px 5px; background: #FFEFD5;" | Lymphocyte depleted | | style="padding: 5px 5px; background: #FFEFD5;" | Lymphocyte depleted | ||
| style="padding: 5px 5px; background: #FFEFD5;" | | | style="padding: 5px 5px; background: #FFEFD5;" | Rare subtype, composed of large numbers of often pleomorphic RS cells with only few reactive lymphocytes which may easily be confused with diffuse large cell lymphoma. Many cases previously classified within this category would now be reclassified under anaplastic large cell lymphoma | ||
|- | |- | ||
| style="padding: 5px 5px; background: #FFEFD5;" | Unspecified | | style="padding: 5px 5px; background: #FFEFD5;" | Unspecified | ||
| style="padding: 5px 5px; background: #FFEFD5;" | | | style="padding: 5px 5px; background: #FFEFD5;" | | ||
|} | |} | ||
Revision as of 20:46, 3 September 2015
| B-cell neoplasms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CD5+ | CD5- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCND1+ | CCND1- | DLBCL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pleomorphic MCL | DLBCL, NOS CD5+ | CD10+ | CD10- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BCL6+ IRF4/MUM1- | BCL6+ IRF4/MUM1+ | BCL6- IRF4/MUM1+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | Non-GCB | Post-GCB | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Neoplasms
| B-cell neoplasms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CD5+ | CD5- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCND1+ | CCND1- | DLBCL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pleomorphic MCL | DLBCL, NOS CD5+ | CD10+ | CD10- | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BCL6+ IRF4/MUM1- | BCL6+ IRF4/MUM1+ | BCL6- IRF4/MUM1+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DLBCL, NOS GCB type | Non-GCB | Post-GCB | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Name | Description |
|---|---|
| Nodular sclerosing Hodgkins lymphoma | Most common subtype and is composed of large tumor nodules showing scattered lacunar classical Reed–Sternberg cells set in a background of reactive lymphocytes, eosinophils, and plasma cells with varying degrees of collagen fibrosis/sclerosis. |
| Mixed-cellularity subtype | Common subtype and is composed of numerous classic Reed-Sternberg cells admixed with numerous inflammatory cells including lymphocytes, histiocytes, eosinophils, and plasma cells without sclerosis. This type is most often associated with Epstein–Barr virus (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma. |
| Lymphocyte-rich | Rare subtype, show many features which may cause diagnostic confusion with nodular lymphocyte predominant B-cell Non-Hodgkin's Lymphoma (B-NHL). This form also has the most favorable prognosis. |
| Lymphocyte depleted | Rare subtype, composed of large numbers of often pleomorphic RS cells with only few reactive lymphocytes which may easily be confused with diffuse large cell lymphoma. Many cases previously classified within this category would now be reclassified under anaplastic large cell lymphoma |
| Unspecified |