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! style="background: #FFA07A; color:#FFF;" | Description
! style="background: #FFA07A; color:#FFF;" | Description
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| style="padding: 5px 5px; background: #FFDAB9;" | Nodular sclerosing Hodgkins lymphoma
| style="padding: 5px 5px; background: #FFEFD5;" | Nodular sclerosing Hodgkins lymphoma
| style="padding: 5px 5px; background: #FFDAB9;" | Most common subtype and is composed of large [[tumor]] nodules showing scattered lacunar classical Reed–Sternberg cells set in a background of reactive [[lymphocytes]], [[eosinophils]], and [[plasma cells]] with varying degrees of collagen [[fibrosis]]/[[sclerosis]].
| style="padding: 5px 5px; background: #FFEFD5;" | Most common subtype and is composed of large [[tumor]] nodules showing scattered lacunar classical Reed–Sternberg cells set in a background of reactive [[lymphocytes]], [[eosinophils]], and [[plasma cells]] with varying degrees of collagen [[fibrosis]]/[[sclerosis]].
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| style="padding: 5px 5px; background: #FFDAB9;" | Mixed-cellularity subtype
| style="padding: 5px 5px; background: #FFEFD5;" | Mixed-cellularity subtype
| style="padding: 5px 5px; background: #FFDAB9;" |  
| style="padding: 5px 5px; background: #FFEFD5;" |  
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| style="padding: 5px 5px; background: #FFDAB9;" | Lymphocyte-rich
| style="padding: 5px 5px; background: #FFEFD5;" | Lymphocyte-rich
| style="padding: 5px 5px; background: #FFDAB9;" |  
| style="padding: 5px 5px; background: #FFEFD5;" |  
|-
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| style="padding: 5px 5px; background: #FFDAB9;" | Lymphocyte depleted
| style="padding: 5px 5px; background: #FFEFD5;" | Lymphocyte depleted
| style="padding: 5px 5px; background: #FFDAB9;" |  
| style="padding: 5px 5px; background: #FFEFD5;" |  
|-
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| style="padding: 5px 5px; background: #FFDAB9;" | Unspecified
| style="padding: 5px 5px; background: #FFEFD5;" | Unspecified
| style="padding: 5px 5px; background: #FFDAB9;" |
| style="padding: 5px 5px; background: #FFEFD5;" |
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Revision as of 20:40, 3 September 2015

 
 
 
 
 
 
 
 
 
B-cell neoplasms
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CD5+
 
 
 
 
 
 
 
CD5-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CCND1+
 
 
 
CCND1-
 
 
 
 
DLBCL
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pleomorphic MCL
 
 
 
DLBCL, NOS CD5+
 
CD10+
 
 
 
 
 
 
 
CD10-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DLBCL, NOS GCB type
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
BCL6+ IRF4/MUM1-
 
BCL6+ IRF4/MUM1+
 
BCL6- IRF4/MUM1+
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DLBCL, NOS GCB type
 
Non-GCB
 
Post-GCB
 
 



Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Neoplasms


 
 
 
 
 
 
 
 
 
B-cell neoplasms
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CD5+
 
 
 
 
 
 
 
CD5-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CCND1+
 
 
 
CCND1-
 
 
 
 
DLBCL
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pleomorphic MCL
 
 
 
DLBCL, NOS CD5+
 
CD10+
 
 
 
 
 
 
 
CD10-
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DLBCL, NOS GCB type
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
BCL6+ IRF4/MUM1-
 
BCL6+ IRF4/MUM1+
 
BCL6- IRF4/MUM1+
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DLBCL, NOS GCB type
 
Non-GCB
 
Post-GCB
 
 
Hodgkins lymphoma classification
Name Description
Nodular sclerosing Hodgkins lymphoma Most common subtype and is composed of large tumor nodules showing scattered lacunar classical Reed–Sternberg cells set in a background of reactive lymphocytes, eosinophils, and plasma cells with varying degrees of collagen fibrosis/sclerosis.
Mixed-cellularity subtype
Lymphocyte-rich
Lymphocyte depleted
Unspecified