Sandbox sowminya: Difference between revisions

Latest revision as of 20:06, 23 March 2016

B-cell neoplasms

CD5+

CD5-

CCND1+

CCND1-

DLBCL

Pleomorphic MCL

DLBCL, NOS CD5+

CD10+

CD10-

DLBCL, NOS GCB type

BCL6+ IRF4/MUM1-

BCL6+ IRF4/MUM1+

BCL6- IRF4/MUM1+

DLBCL, NOS GCB type

Non-GCB

Post-GCB

B-cell neoplasms

CD5+

CD5-

CCND1+

CCND1-

DLBCL

Pleomorphic MCL

DLBCL, NOS CD5+

CD10+

CD10-

DLBCL, NOS GCB type

BCL6+ IRF4/MUM1-

BCL6+ IRF4/MUM1+

BCL6- IRF4/MUM1+

DLBCL, NOS GCB type

Non-GCB

Post-GCB

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-==Overview==
-'''Primary effusion lymphoma''' (PEL) is a malignancy of B cells that is caused by [[Kaposi's sarcoma-associated herpesvirus]] (KSHV), also known as human herpesvirus 8 (HHV-8)<ref>Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995;332(18):1186-91.</ref>. In about 80% of cases, the lymphoma cells are also infected with [[Epstein Barr virus]] (EBV).  PEL is unusual in that the majority of cases arise in body cavities, such as the pleural space or the pericardium<ref>Staudt MR, Kanan Y, Jeong JH, Papin JF, Hines-Boykin R, Dittmer DP. The tumor microenvironment controls primary effusion lymphoma growth in vivo. Cancer Res 2004;64(14):4790-9.</ref>.
-==Historical Perspective==
-Primary effusion lymphoma was recognized as a unique type of lymphoma only after the discovery of KSHV in 1994.
-PEL most commonly arises in patients with underlying immunodeficiency, such as AIDS[1]. It is caused by Kaposi's sarcoma-associated herpesvirus (KSHV).