Sandbox:ddx graves: Difference between revisions
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{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | {| style="border: 0px; font-size: 90%; margin: 3px;" align=center | ||
! colspan="2" rowspan="1" style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Disease}} | ! colspan="2" rowspan="1" style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Disease}} | ||
|{{fontcolor|#FFFFFF|Findings}} | |style="background: #4479BA; padding: 5px 5px;"|{{fontcolor|#FFFFFF|Findings}} | ||
|- | |- | ||
| style="background: #4479BA; padding: 5px 5px;" rowspan=5 colspan=1 |{{fontcolor|#FFFFFF|Thyroiditis}} | | style="background: #4479BA; padding: 5px 5px;" rowspan=5 colspan=1 |{{fontcolor|#FFFFFF|Thyroiditis}} | ||
| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Direct chemical toxicity with inflammation | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Amiodarone, sunitinib, pazopanib, axitinib, and other tyrosine kinase inhibitors may also be associated with a destructive thyroiditis. | | style="padding: 5px 5px; background: #F5F5F5;" | Amiodarone, sunitinib, pazopanib, axitinib, and other tyrosine kinase inhibitors may also be associated with a destructive thyroiditis. | ||
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| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Radiation thyroiditis | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Patients who treated with radioiodine, may develops thyroid pain and tenderness 5 to 10 days later, due to radiation-induced injury and necrosis of thyroid follicular cells and associated inflammation. | | style="padding: 5px 5px; background: #F5F5F5;" | Patients who treated with radioiodine, may develops thyroid pain and tenderness 5 to 10 days later, due to radiation-induced injury and necrosis of thyroid follicular cells and associated inflammation. | ||
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| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Drugs that interfere with the immune system | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Interferon-alfa is well known for associated thyroid abnormality. It mostly lead to development of de novo antithyroid antibodies. | | style="padding: 5px 5px; background: #F5F5F5;" | Interferon-alfa is well known for associated thyroid abnormality. It mostly lead to development of de novo antithyroid antibodies. | ||
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| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Lithium | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Patients treated with lithium are at high risk to develop painless thyroiditis and Graves' disease. | | style="padding: 5px 5px; background: #F5F5F5;" | Patients treated with lithium are at high risk to develop painless thyroiditis and Graves' disease. | ||
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| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Palpation thyroiditis | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Manipulation of thyroid gland during thyroid biopsy or neck surgery and vigorous palpation during physical examination may cause transient hyperthyroidism. | | style="padding: 5px 5px; background: #F5F5F5;" | Manipulation of thyroid gland during thyroid biopsy or neck surgery and vigorous palpation during physical examination may cause transient hyperthyroidism. | ||
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| style="background: #4479BA; padding: 5px 5px;" rowspan=4 colspan=1 |{{fontcolor|#FFFFFF|Exogenous and ectopic hyperthyroidism }} | | style="background: #4479BA; padding: 5px 5px;" rowspan=4 colspan=1 |{{fontcolor|#FFFFFF|Exogenous and ectopic hyperthyroidism }} | ||
| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Factitious ingestion of thyroid hormone | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Acute hyperthyroidism from a levothyroxine overdose | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Struma ovarii | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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| style="padding: 5px 5px; background: # | | style="padding: 5px 5px; background: #4479BA;" | Functional thyroid cancer metastases | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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Revision as of 17:18, 14 December 2016
ss
| Disease | Findings | |
|---|---|---|
| Thyroiditis | Direct chemical toxicity with inflammation | Amiodarone, sunitinib, pazopanib, axitinib, and other tyrosine kinase inhibitors may also be associated with a destructive thyroiditis. |
| Radiation thyroiditis | Patients who treated with radioiodine, may develops thyroid pain and tenderness 5 to 10 days later, due to radiation-induced injury and necrosis of thyroid follicular cells and associated inflammation. | |
| Drugs that interfere with the immune system | Interferon-alfa is well known for associated thyroid abnormality. It mostly lead to development of de novo antithyroid antibodies. | |
| Lithium | Patients treated with lithium are at high risk to develop painless thyroiditis and Graves' disease. | |
| Palpation thyroiditis | Manipulation of thyroid gland during thyroid biopsy or neck surgery and vigorous palpation during physical examination may cause transient hyperthyroidism. | |
| Exogenous and ectopic hyperthyroidism | Factitious ingestion of thyroid hormone | |
| Acute hyperthyroidism from a levothyroxine overdose | ||
| Struma ovarii | ||
| Functional thyroid cancer metastases | ||
| Hashitoxicosis | It is autoimmune thyroid disease who initially present with hyperthyroidism and a high radioiodine uptake caused by TSH-receptor antibodies similar to Graves' disease followed by the development of hypothyroidism due to infiltration of thyroid gland with lymphocytes and resultant autoimmune-mediated destruction of thyroid tissue similar to chronic lymphocytic thyroiditis.[1] | |
| Toxic adenoma and toxic multinodular goiter | Toxic adenoma and toxic multinodular goiter are result of focal/diffuse hyperplasia of thyroid follicular cells independent to TSH regulation. Finding single or multiple nodules in physical examination or thyroid scan.[2] | |
| Iodine-induced hyperthyroidism | It is uncommon but, can develop after an iodine load, such as administration of contrast agents used for angiography or computed tomography (CT) or iodine-rich drugs such as amiodarone. | |
| Trophoblastic disease and germ cell tumors | ||