Sandbox: maria
|
Medulloblastoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case studies |
|
Sandbox: maria On the Web |
|
American Roentgen Ray Society Images of Sandbox: maria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Medulloblastoma arises from embryonal cells, which are stem cells that are normally involved in development of the fourth ventricle.[1]
Genetics
- Development of medulloblastoma is the result of multiple genetic mutations.
- Genes involved in the pathogenesis of medulloblastoma include:
- CTNNB1
- PTCH1
- MLL2
- SMARCA4
- DDX3X
- CTDNEP
- KDM6A
- TBR1
Associated Conditions
Gross Pathology
Micropathology
- On microscopic histopathological analysis, characteristic findings of medulloblastoma include:[2]
- Small round cell tumor
- Homer-Wright rosettes
- MAP2 +ve
- Synaptophysin +ve
- NSE +ve/-ve
- NF +ve/-ve
- Chromogranin +ve/-ve
- GFAP +ve/-ve
- Vimentin +ve
- Nestin +ve
- INI1 retained
References
- ↑ Medulloblastoma. Wikipedia (2015)https://en.wikipedia.org/wiki/Medulloblastoma#Pathogenesis Accessed on November,10 2015
- ↑ Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015
- ↑ Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015
- ↑ Schmidt C (2015). "Targeted Therapy Makes Inroads in Medulloblastoma". J. Natl. Cancer Inst. 107 (11). doi:10.1093/jnci/djv353. PMID 26538622.
- ↑ Grisold W, Soffietti R. Neuro-Oncology, Part II, Handbook of Clinical Neurology (Series editors: Aminoff, Boller, Swaab). Elsevier; 2012.