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{{Infobox_gene}}
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'''Sulfatase-modifying factor 2''' is an [[enzyme]] that in humans is encoded by the ''SUMF2'' [[gene]].<ref name="pmid12757706">{{cite journal | vauthors = Cosma MP, Pepe S, Annunziata I, Newbold RF, Grompe M, Parenti G, Ballabio A | title = The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases | journal = Cell | volume = 113 | issue = 4 | pages = 445–56 |date=May 2003 | pmid = 12757706 | pmc = | doi =10.1016/S0092-8674(03)00348-9  }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = PBB_Protein_SUMF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y4j.
| PDB = {{PDB2|1y4j}}
| Name = Sulfatase modifying factor 2
| HGNCid = 20415
| Symbol = SUMF2
| AltSymbols =; DKFZp566I1024; DKFZp66I1024; DKFZp686L17160; DKFZp781L1035; MGC99485; pFGE
| OMIM = 607940
| ECnumber = 
| Homologene = 41037
| MGIid = 1915152
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25870
    | Hs_Ensembl = ENSG00000129103
    | Hs_RefseqProtein = NP_001035933
    | Hs_RefseqmRNA = NM_001042468
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 56099452
    | Hs_GenLoc_end = 56115851
    | Hs_Uniprot = Q8NBJ7
    | Mm_EntrezGene = 67902
    | Mm_Ensembl = ENSMUSG00000025538
    | Mm_RefseqmRNA = XM_974746
    | Mm_RefseqProtein = XP_979840
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 130131699
    | Mm_GenLoc_end = 130148660
    | Mm_Uniprot = Q0VDW5
  }}
}}
'''Sulfatase modifying factor 2''', also known as '''SUMF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SUMF2 sulfatase modifying factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25870| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: SUMF2 sulfatase modifying factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25870| accessdate = }}</ref>
| summary_text = The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: SUMF2 sulfatase modifying factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25870| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Dierks T, Schmidt B, Borissenko LV, ''et al.'' |title=Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. |journal=Cell |volume=113 |issue= 4 |pages= 435-44 |year= 2003 |pmid= 12757705 |doi= }}
*{{cite journal   |vauthors=Dierks T, Schmidt B, Borissenko LV, etal |title=Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme |journal=Cell |volume=113 |issue= 4 |pages= 435–44 |year= 2003 |pmid= 12757705 |doi=10.1016/S0092-8674(03)00347-7 }}
*{{cite journal  | author=Cosma MP, Pepe S, Annunziata I, ''et al.'' |title=The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. |journal=Cell |volume=113 |issue= 4 |pages= 445-56 |year= 2003 |pmid= 12757706 |doi= }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Landgrebe J, Dierks T, Schmidt B, von Figura K |title=The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes |journal=Gene |volume=316 |issue=  |pages= 47–56 |year= 2004 |pmid= 14563551 |doi=10.1016/S0378-1119(03)00746-7 }}
*{{cite journal  | author=Landgrebe J, Dierks T, Schmidt B, von Figura K |title=The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes. |journal=Gene |volume=316 |issue=  |pages= 47-56 |year= 2004 |pmid= 14563551 |doi=  }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Dickmanns A, Schmidt B, Rudolph MG, etal |title=Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15180–7 |year= 2005 |pmid= 15687489 |doi= 10.1074/jbc.M414317200 }}
*{{cite journal | author=Dickmanns A, Schmidt B, Rudolph MG, ''et al.'' |title=Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15180-7 |year= 2005 |pmid= 15687489 |doi= 10.1074/jbc.M414317200 }}
*{{cite journal   |vauthors=Mariappan M, Preusser-Kunze A, Balleininger M, etal |title=Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15173–9 |year= 2005 |pmid= 15708861 |doi= 10.1074/jbc.M413698200 }}
*{{cite journal | author=Mariappan M, Preusser-Kunze A, Balleininger M, ''et al.'' |title=Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15173-9 |year= 2005 |pmid= 15708861 |doi= 10.1074/jbc.M413698200 }}
*{{cite journal   |vauthors=Zito E, Fraldi A, Pepe S, etal |title=Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2 |journal=EMBO Rep. |volume=6 |issue= 7 |pages= 655–60 |year= 2005 |pmid= 15962010 |doi= 10.1038/sj.embor.7400454 | pmc=1369113 }}
*{{cite journal | author=Zito E, Fraldi A, Pepe S, ''et al.'' |title=Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. |journal=EMBO Rep. |volume=6 |issue= 7 |pages= 655-60 |year= 2005 |pmid= 15962010 |doi= 10.1038/sj.embor.7400454 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=25870}}
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{{gene-7-stub}}
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Latest revision as of 07:17, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene.[1][2]

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

References

  1. ↑ Cosma MP, Pepe S, Annunziata I, Newbold RF, Grompe M, Parenti G, Ballabio A (May 2003). "The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases". Cell. 113 (4): 445–56. doi:10.1016/S0092-8674(03)00348-9. PMID 12757706.
  2. ↑ 2.0 2.1 "Entrez Gene: SUMF2 sulfatase modifying factor 2".

Further reading



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