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{{Infobox_gene}}
{{PBB_Controls
'''Syntaxin-binding protein 1''' (also known as [[Munc18|Munc18-1]]) is a [[protein]] that in humans is encoded by the ''STXBP1'' [[gene]].<ref name="pmid9545644">{{cite journal | vauthors = Swanson DA, Steel JM, Valle D | title = Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release | journal = Genomics | volume = 48 | issue = 3 | pages = 373–6  | date = Jun 1998 | pmid = 9545644 | pmc = | doi = 10.1006/geno.1997.5202 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STXBP1 syntaxin binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6812| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
In melanocytic cells STXBP1 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_STXBP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dn1.
| PDB = {{PDB2|1dn1}}
| Name = Syntaxin binding protein 1
| HGNCid = 11444
| Symbol = STXBP1
| AltSymbols =; MUNC18-1; UNC18; hUNC18; rbSec1
| OMIM = 602926
| ECnumber =
| Homologene = 2382
| MGIid = 107363
| GeneAtlas_image1 = PBB_GE_STXBP1_202260_s_at_tn.png
| Function =  
| Component =  
| Process = {{GNF_GO|id=GO:0006904 |text = vesicle docking during exocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6812
    | Hs_Ensembl = ENSG00000136854
    | Hs_RefseqProtein = NP_001027392
    | Hs_RefseqmRNA = NM_001032221
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 129414365
    | Hs_GenLoc_end = 129494816
    | Hs_Uniprot = P61764
    | Mm_EntrezGene = 20910
    | Mm_Ensembl = ENSMUSG00000026797
    | Mm_RefseqmRNA = NM_009295
    | Mm_RefseqProtein = NP_033321
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 32609971
    | Mm_GenLoc_end = 32669173
    | Mm_Uniprot = Q5WAC6
  }}
}}
'''Syntaxin binding protein 1''', also known as '''STXBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STXBP1 syntaxin binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6812| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene was initially discovered in 2008 as cause for [[Ohtahara Syndrome]]. Ever since, it has become one of the most prominent genes for epileptic encephalopathies so far.<ref>[http://epilepsygenetics.net/2015/08/04/stxbp1-this-is-what-you-need-to-know-in-2015/ STXBP1 – this is what you need to know in 2015]</ref>
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
STXBP1 has been shown to [[Protein-protein interaction|interact]] with [[STX2]],<ref name=pmid12773094>{{cite journal | vauthors = Schraw TD, Lemons PP, Dean WL, Whiteheart SW | title = A role for Sec1/Munc18 proteins in platelet exocytosis | journal = Biochem. J. | volume = 374 | issue = Pt 1 | pages = 207–17  | date = Aug 2003 | pmid = 12773094 | pmc = 1223584 | doi = 10.1042/BJ20030610 }}</ref><ref name=pmid7768895>{{cite journal | vauthors = Hata Y, Südhof TC | title = A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic | journal = J. Biol. Chem. | volume = 270 | issue = 22 | pages = 13022–8  | date = Jun 1995 | pmid = 7768895 | doi = 10.1074/jbc.270.22.13022 }}</ref> [[STX4]]<ref name=pmid12773094/><ref name=pmid7768895/> and [[STX1A]].<ref name=pmid7768895/><ref name=pmid12963086>{{cite journal | vauthors = Bhaskar K, Shareef MM, Sharma VM, Shetty AP, Ramamohan Y, Pant HC, Raju TR, Shetty KT | title = Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins | journal = Neurochem. Int. | volume = 44 | issue = 1 | pages = 35–44  | date = Jan 2004 | pmid = 12963086 | doi = 10.1016/S0197-0186(03)00099-8 }}</ref><ref name=pmid10449403>{{cite journal | vauthors = Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J | title = A conformational switch in syntaxin during exocytosis: role of munc18 | journal = EMBO J. | volume = 18 | issue = 16 | pages = 4372–82  | date = Aug 1999 | pmid = 10449403 | pmc = 1171512 | doi = 10.1093/emboj/18.16.4372 }}</ref><ref name=pmid7553862>{{cite journal | vauthors = McMahon HT, Missler M, Li C, Südhof TC | title = Complexins: cytosolic proteins that regulate SNAP receptor function | journal = Cell | volume = 83 | issue = 1 | pages = 111–9  | date = Oct 1995 | pmid = 7553862 | doi = 10.1016/0092-8674(95)90239-2 }}</ref><ref name=pmid12093152>{{cite journal | vauthors = Pérez-Brangulí F, Muhaisen A, Blasi J | title = Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay | journal = Mol. Cell. Neurosci. | volume = 20 | issue = 2 | pages = 169–80  | date = Jun 2002 | pmid = 12093152 | doi = 10.1006/mcne.2002.1122 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Garcia EP, McPherson PS, Chilcote TJ, Takei K, De Camilli P | title = rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin | journal = J. Cell Biol. | volume = 129 | issue = 1 | pages = 105–20 | year = 1995 | pmid = 7698978 | pmc = 2120371 | doi = 10.1083/jcb.129.1.105 }}
| citations =
* {{cite journal | vauthors = Pevsner J, Hsu SC, Scheller RH | title = n-Sec1: a neural-specific syntaxin-binding protein | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 4 | pages = 1445–9 | year = 1994 | pmid = 8108429 | pmc = 43176 | doi = 10.1073/pnas.91.4.1445 }}
*{{cite journal | author=Garcia EP, McPherson PS, Chilcote TJ, ''et al.'' |title=rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. |journal=J. Cell Biol. |volume=129 |issue= 1 |pages= 105-20 |year= 1995 |pmid= 7698978 |doi= }}
* {{cite journal | vauthors = Fujita Y, Sasaki T, Fukui K, Kotani H, Kimura T, Hata Y, Südhof TC, Scheller RH, Takai Y | title = Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin | journal = J. Biol. Chem. | volume = 271 | issue = 13 | pages = 7265–8 | year = 1996 | pmid = 8631738 | doi = 10.1074/jbc.271.13.7265 }}
*{{cite journal  | author=Pevsner J, Hsu SC, Scheller RH |title=n-Sec1: a neural-specific syntaxin-binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 4 |pages= 1445-9 |year= 1994 |pmid= 8108429 |doi= }}
* {{cite journal | vauthors = Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y | title = A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants | journal = J. Neurosci. | volume = 16 | issue = 21 | pages = 6695–702 | year = 1996 | pmid = 8824310 | doi =  }}
*{{cite journal | author=Fujita Y, Sasaki T, Fukui K, ''et al.'' |title=Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7265-8 |year= 1996 |pmid= 8631738 |doi= }}
* {{cite journal | vauthors = Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE | title = Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4 | journal = J. Biol. Chem. | volume = 272 | issue = 10 | pages = 6179–86 | year = 1997 | pmid = 9045631 | doi = 10.1074/jbc.272.10.6179 }}
*{{cite journal | author=Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y |title=A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. |journal=J. Neurosci. |volume=16 |issue= 21 |pages= 6695-702 |year= 1996 |pmid= 8824310 |doi=  }}
* {{cite journal | vauthors = Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC | title = DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion | journal = Neuron | volume = 18 | issue = 3 | pages = 453–61 | year = 1997 | pmid = 9115738 | doi = 10.1016/S0896-6273(00)81245-3 }}
*{{cite journal | author=Tellam JT, Macaulay SL, McIntosh S, ''et al.'' |title=Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6179-86 |year= 1997 |pmid= 9045631 |doi= }}
* {{cite journal | vauthors = Okamoto M, Südhof TC | title = Mints, Munc18-interacting proteins in synaptic vesicle exocytosis | journal = J. Biol. Chem. | volume = 272 | issue = 50 | pages = 31459–64 | year = 1997 | pmid = 9395480 | doi = 10.1074/jbc.272.50.31459 }}
*{{cite journal | author=Verhage M, de Vries KJ, Røshol H, ''et al.'' |title=DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. |journal=Neuron |volume=18 |issue= 3 |pages= 453-61 |year= 1997 |pmid= 9115738 |doi= }}
* {{cite journal | vauthors = Fletcher AI, Shuang R, Giovannucci DR, Zhang L, Bittner MA, Stuenkel EL | title = Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18 | journal = J. Biol. Chem. | volume = 274 | issue = 7 | pages = 4027–35 | year = 1999 | pmid = 9933594 | doi = 10.1074/jbc.274.7.4027 }}
*{{cite journal | author=Okamoto M, Südhof TC |title=Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31459-64 |year= 1998 |pmid= 9395480 |doi= }}
* {{cite journal | vauthors = Reed GL, Houng AK, Fitzgerald ML | title = Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion | journal = Blood | volume = 93 | issue = 8 | pages = 2617–26 | year = 1999 | pmid = 10194441 | doi =  }}
*{{cite journal | author=Swanson DA, Steel JM, Valle D |title=Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release. |journal=Genomics |volume=48 |issue= 3 |pages= 373-6 |year= 1998 |pmid= 9545644 |doi= 10.1006/geno.1997.5202 }}
* {{cite journal | vauthors = Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J | title = A conformational switch in syntaxin during exocytosis: role of munc18 | journal = EMBO J. | volume = 18 | issue = 16 | pages = 4372–82 | year = 1999 | pmid = 10449403 | pmc = 1171512 | doi = 10.1093/emboj/18.16.4372 }}
*{{cite journal | author=Fletcher AI, Shuang R, Giovannucci DR, ''et al.'' |title=Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4027-35 |year= 1999 |pmid= 9933594 |doi=  }}
* {{cite journal | vauthors = Misura KM, Scheller RH, Weis WI | title = Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex | journal = Nature | volume = 404 | issue = 6776 | pages = 355–62 | year = 2000 | pmid = 10746715 | doi = 10.1038/35006120 }}
*{{cite journal | author=Reed GL, Houng AK, Fitzgerald ML |title=Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. |journal=Blood |volume=93 |issue= 8 |pages= 2617-26 |year= 1999 |pmid= 10194441 |doi= }}
* {{cite journal | vauthors = Allan BB, Moyer BD, Balch WE | title = Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion | journal = Science | volume = 289 | issue = 5478 | pages = 444–8 | year = 2000 | pmid = 10903204 | doi = 10.1126/science.289.5478.444 }}
*{{cite journal | author=Dulubova I, Sugita S, Hill S, ''et al.'' |title=A conformational switch in syntaxin during exocytosis: role of munc18. |journal=EMBO J. |volume=18 |issue= 16 |pages= 4372-82 |year= 1999 |pmid= 10449403 |doi= 10.1093/emboj/18.16.4372 }}
* {{cite journal | vauthors = Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G | title = Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 45–62 | year = 2002 | pmid = 11927603 | pmc = 2173270 | doi = 10.1083/jcb.200112127 }}
*{{cite journal | author=Misura KM, Scheller RH, Weis WI |title=Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. |journal=Nature |volume=404 |issue= 6776 |pages= 355-62 |year= 2000 |pmid= 10746715 |doi= 10.1038/35006120 }}
* {{cite journal | vauthors = Ho CS, Marinescu V, Steinhilb ML, Gaut JR, Turner RS, Stuenkel EL | title = Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 27021–8 | year = 2002 | pmid = 12016213 | doi = 10.1074/jbc.M201823200 }}
*{{cite journal | author=Allan BB, Moyer BD, Balch WE |title=Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion. |journal=Science |volume=289 |issue= 5478 |pages= 444-8 |year= 2000 |pmid= 10903204 |doi= }}
* {{cite journal | vauthors = Pérez-Brangulí F, Muhaisen A, Blasi J | title = Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay | journal = Mol. Cell. Neurosci. | volume = 20 | issue = 2 | pages = 169–80 | year = 2002 | pmid = 12093152 | doi = 10.1006/mcne.2002.1122 }}
*{{cite journal | author=Shorter J, Beard MB, Seemann J, ''et al.'' |title=Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 45-62 |year= 2002 |pmid= 11927603 |doi= 10.1083/jcb.200112127 }}
* {{cite journal | vauthors = Barclay JW, Craig TJ, Fisher RJ, Ciufo LF, Evans GJ, Morgan A, Burgoyne RD | title = Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis | journal = J. Biol. Chem. | volume = 278 | issue = 12 | pages = 10538–45 | year = 2003 | pmid = 12519779 | doi = 10.1074/jbc.M211114200 }}
*{{cite journal | author=Ho CS, Marinescu V, Steinhilb ML, ''et al.'' |title=Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27021-8 |year= 2002 |pmid= 12016213 |doi= 10.1074/jbc.M201823200 }}
* {{cite journal | vauthors = Fukuda M | title = Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 15390–6 | year = 2003 | pmid = 12590134 | doi = 10.1074/jbc.M213090200 }}
*{{cite journal | author=Pérez-Brangulí F, Muhaisen A, Blasi J |title=Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. |journal=Mol. Cell. Neurosci. |volume=20 |issue= 2 |pages= 169-80 |year= 2002 |pmid= 12093152 |doi= }}
* {{cite journal | vauthors = Craig TJ, Evans GJ, Morgan A | title = Physiological regulation of Munc18/nSec1 phosphorylation on serine-313 | journal = J. Neurochem. | volume = 86 | issue = 6 | pages = 1450–7 | year = 2003 | pmid = 12950453 | doi = 10.1046/j.1471-4159.2003.01955.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Barclay JW, Craig TJ, Fisher RJ, ''et al.'' |title=Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10538-45 |year= 2003 |pmid= 12519779 |doi= 10.1074/jbc.M211114200 }}
*{{cite journal  | author=Fukuda M |title=Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15390-6 |year= 2003 |pmid= 12590134 |doi= 10.1074/jbc.M213090200 }}
*{{cite journal  | author=Craig TJ, Evans GJ, Morgan A |title=Physiological regulation of Munc18/nSec1 phosphorylation on serine-313. |journal=J. Neurochem. |volume=86 |issue= 6 |pages= 1450-7 |year= 2003 |pmid= 12950453 |doi=  }}
}}
{{refend}}
{{refend}}


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{{PDB Gallery|geneid=6812}}
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Revision as of 21:14, 30 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Syntaxin-binding protein 1 (also known as Munc18-1) is a protein that in humans is encoded by the STXBP1 gene.[1][2]

In melanocytic cells STXBP1 gene expression may be regulated by MITF.[3]

This gene was initially discovered in 2008 as cause for Ohtahara Syndrome. Ever since, it has become one of the most prominent genes for epileptic encephalopathies so far.[4]

Interactions

STXBP1 has been shown to interact with STX2,[5][6] STX4[5][6] and STX1A.[6][7][8][9][10]

References

  1. ↑ Swanson DA, Steel JM, Valle D (Jun 1998). "Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release". Genomics. 48 (3): 373–6. doi:10.1006/geno.1997.5202. PMID 9545644.
  2. ↑ "Entrez Gene: STXBP1 syntaxin binding protein 1".
  3. ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  4. ↑ STXBP1 – this is what you need to know in 2015
  5. ↑ 5.0 5.1 Schraw TD, Lemons PP, Dean WL, Whiteheart SW (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
  6. ↑ 6.0 6.1 6.2 Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
  7. ↑ Bhaskar K, Shareef MM, Sharma VM, Shetty AP, Ramamohan Y, Pant HC, Raju TR, Shetty KT (Jan 2004). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins". Neurochem. Int. 44 (1): 35–44. doi:10.1016/S0197-0186(03)00099-8. PMID 12963086.
  8. ↑ Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.
  9. ↑ McMahon HT, Missler M, Li C, Südhof TC (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862.
  10. ↑ Pérez-Brangulí F, Muhaisen A, Blasi J (Jun 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.

Further reading


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