SSR4: Difference between revisions

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'''Translocon-associated protein subunit delta''' is a [[protein]] that in humans is encoded by the ''SSR4'' [[gene]].<ref name="pmid9286695">{{cite journal | vauthors = Brenner V, Nyakatura G, Rosenthal A, Platzer M | title = Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse | journal = Genomics | volume = 44 | issue = 1 | pages = 8–14 |date=Nov 1997 | pmid = 9286695 | pmc =  | doi = 10.1006/geno.1997.4822 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6748| accessdate = }}</ref>
'''Translocon-associated protein subunit delta''' is a [[protein]] that in humans is encoded by the ''SSR4'' [[gene]].<ref name="pmid9286695">{{cite journal | vauthors = Brenner V, Nyakatura G, Rosenthal A, Platzer M | title = Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse | journal = Genomics | volume = 44 | issue = 1 | pages = 8–14 |date=Nov 1997 | pmid = 9286695 | pmc =  | doi = 10.1006/geno.1997.4822 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6748| accessdate = }}</ref>
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| summary_text = SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.<ref name="entrez" />
| summary_text = SSR4, also called TRAPD, is assumed to be involved in [[protein secretion]]. It is located in the [[Xq28]] region, arranged in a compact head-to-head manner with the [[IDH3G]] gene. These two genes are driven by a bidirectional [[promoter (genetics)|promoter]] located between them, and encode proteins involved in unrelated [[biochemical pathways]] located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a [[CpG island]]. The CpG island functions as a bidirectional promoter to initiate the [[transcription (biology)|transcription]] of both functionally unrelated genes with distinct [[gene expression|expression]] patterns. SSR4 consists of six [[exons]] and is approximately 70 kb telomeric to the ALD gene. Although [[alternative splicing]] of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both ''[[Xenopus laevis]]'' and ''[[Mus musculus]]''.<ref name="entrez" />
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Latest revision as of 21:45, 20 February 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
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Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4 gene.[1][2]

SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.[2]

References

  1. ↑ Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
  2. ↑ 2.0 2.1 "Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)".

Further reading



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