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{{Infobox_gene}}
{{PBB_Controls
'''Small nuclear ribonucleoprotein-associated proteins B and B'''' is a [[protein]] that in humans is encoded by the ''SNRPB'' [[gene]].<ref name="pmid1376292">{{cite journal | vauthors = Griffith AJ, Schmauss C, Craft J | title = The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site | journal = Gene | volume = 114 | issue = 2 | pages = 195–201  | date = July 1992 | pmid = 1376292 | pmc =  | doi = 10.1016/0378-1119(92)90574-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6628| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SNRPB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d3b.
| PDB = {{PDB2|1d3b}}
| Name = Small nuclear ribonucleoprotein polypeptides B and B1
| HGNCid = 11153
| Symbol = SNRPB
| AltSymbols =; SNRPB1; COD; SmB/SmB'; snRNP-B
| OMIM = 182282
| ECnumber = 
| Homologene = 21719
| MGIid = 98342
| GeneAtlas_image1 = PBB_GE_SNRPB_208821_at_tn.png
| GeneAtlas_image2 = PBB_GE_SNRPB_213175_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}} {{GNF_GO|id=GO:0030532 |text = small nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0016071 |text = mRNA metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6628
    | Hs_Ensembl = ENSG00000125835
    | Hs_RefseqProtein = NP_003082
    | Hs_RefseqmRNA = NM_003091
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 2390281
    | Hs_GenLoc_end = 2399499
    | Hs_Uniprot = P14678
    | Mm_EntrezGene = 20638
    | Mm_Ensembl = ENSMUSG00000027404
    | Mm_RefseqmRNA = NM_009225
    | Mm_RefseqProtein = NP_033251
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 129863076
    | Mm_GenLoc_end = 129870844
    | Mm_Uniprot = P27048
  }}
}}
'''Small nuclear ribonucleoprotein polypeptides B and B1''', also known as '''SNRPB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6628| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6628| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Will CL, Lührmann R |title=Spliceosomal UsnRNP biogenesis, structure and function. |journal=Curr. Opin. Cell Biol. |volume=13 |issue= 3 |pages= 290-301 |year= 2001 |pmid= 11343899 |doi=  }}
*{{cite journal  | author=Griffith AJ, Schmauss C, Craft J |title=The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site. |journal=Gene |volume=114 |issue= 2 |pages= 195-201 |year= 1992 |pmid= 1376292 |doi=  }}
*{{cite journal  | author=Schmauss C, Lerner MR |title=The closely related small nuclear ribonucleoprotein polypeptides N and B/B' are distinguishable by antibodies as well as by differences in their mRNAs and gene structures. |journal=J. Biol. Chem. |volume=265 |issue= 18 |pages= 10733-9 |year= 1990 |pmid= 1693924 |doi=  }}
*{{cite journal  | author=Elkon KB, Hines JJ, Chu JL, Parnassa A |title=Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction. |journal=J. Immunol. |volume=145 |issue= 2 |pages= 636-43 |year= 1990 |pmid= 1694885 |doi=  }}
*{{cite journal  | author=Chu JL, Elkon KB |title=The small nuclear ribonucleoproteins, SmB and B', are products of a single gene. |journal=Gene |volume=97 |issue= 2 |pages= 311-2 |year= 1991 |pmid= 1825643 |doi=  }}
*{{cite journal  | author=Sharpe NG, Williams DG, Latchman DS |title=Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation. |journal=Mol. Cell. Biol. |volume=10 |issue= 12 |pages= 6817-20 |year= 1991 |pmid= 2174118 |doi=  }}
*{{cite journal  | author=Schmauss C, McAllister G, Ohosone Y, ''et al.'' |title=A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'. |journal=Nucleic Acids Res. |volume=17 |issue= 4 |pages= 1733-43 |year= 1989 |pmid= 2522186 |doi=  }}
*{{cite journal  | author=Feeney RJ, Sauterer RA, Feeney JL, Zieve GW |title=Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles. |journal=J. Biol. Chem. |volume=264 |issue= 10 |pages= 5776-83 |year= 1989 |pmid= 2522439 |doi=  }}
*{{cite journal  | author=Ohosone Y, Mimori T, Griffith A, ''et al.'' |title=Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 11 |pages= 4249-53 |year= 1989 |pmid= 2524838 |doi=  }}
*{{cite journal  | author=van Dam A, Winkel I, Zijlstra-Baalbergen J, ''et al.'' |title=Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3853-60 |year= 1990 |pmid= 2531083 |doi=  }}
*{{cite journal  | author=Huntriss JD, Latchman DS, Williams DG |title=Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B'. |journal=Clin. Exp. Immunol. |volume=92 |issue= 2 |pages= 263-7 |year= 1993 |pmid= 7683587 |doi=  }}
*{{cite journal  | author=Gerrelli D, Grimaldi K, Horn D, ''et al.'' |title=The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein. |journal=J. Mol. Cell. Cardiol. |volume=25 |issue= 3 |pages= 321-9 |year= 1993 |pmid= 8510173 |doi= 10.1006/jmcc.1993.1038 }}
*{{cite journal  | author=Simons A, Melamed-Bessudo C, Wolkowicz R, ''et al.'' |title=PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb. |journal=Oncogene |volume=14 |issue= 2 |pages= 145-55 |year= 1997 |pmid= 9010216 |doi= 10.1038/sj.onc.1200825 }}
*{{cite journal  | author=Liu Q, Fischer U, Wang F, Dreyfuss G |title=The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. |journal=Cell |volume=90 |issue= 6 |pages= 1013-21 |year= 1997 |pmid= 9323129 |doi=  }}
*{{cite journal  | author=Fury MG, Zhang W, Christodoulopoulos I, Zieve GW |title=Multiple protein: protein interactions between the snRNP common core proteins. |journal=Exp. Cell Res. |volume=237 |issue= 1 |pages= 63-9 |year= 1998 |pmid= 9417867 |doi= 10.1006/excr.1997.3750 }}
*{{cite journal  | author=Bedford MT, Reed R, Leder P |title=WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10602-7 |year= 1998 |pmid= 9724750 |doi=  }}
*{{cite journal  | author=Kambach C, Walke S, Young R, ''et al.'' |title=Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. |journal=Cell |volume=96 |issue= 3 |pages= 375-87 |year= 1999 |pmid= 10025403 |doi=  }}
*{{cite journal  | author=Gray TA, Smithwick MJ, Schaldach MA, ''et al.'' |title=Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci. |journal=Nucleic Acids Res. |volume=27 |issue= 23 |pages= 4577-84 |year= 2000 |pmid= 10556313 |doi=  }}
*{{cite journal  | author=Charroux B, Pellizzoni L, Perkinson RA, ''et al.'' |title=Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1181-94 |year= 2000 |pmid= 10601333 |doi=  }}
*{{cite journal  | author=Charroux B, Pellizzoni L, Perkinson RA, ''et al.'' |title=Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. |journal=J. Cell Biol. |volume=148 |issue= 6 |pages= 1177-86 |year= 2000 |pmid= 10725331 |doi=  }}
}}
{{refend}}


{{protein-stub}}
SNRPB has been shown to [[Protein-protein interaction|interact]] with [[DDX20]]<ref name=pmid10601333>{{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94  | date = Dec 1999 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181 }}</ref> and [[Coilin]].<ref name=pmid11641277>{{cite journal | vauthors = Hebert MD, Szymczyk PW, Shpargel KB, Matera AG | title = Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein | journal = Genes Dev. | volume = 15 | issue = 20 | pages = 2720–9  | date = October 2001 | pmid = 11641277 | pmc = 312817 | doi = 10.1101/gad.908401 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Will CL, Lührmann R | title = Spliceosomal UsnRNP biogenesis, structure and function | journal = Curr. Opin. Cell Biol. | volume = 13 | issue = 3 | pages = 290–301 | year = 2001 | pmid = 11343899 | doi = 10.1016/S0955-0674(00)00211-8 }}
* {{cite journal | vauthors = Schmauss C, Lerner MR | title = The closely related small nuclear ribonucleoprotein polypeptides N and B/B' are distinguishable by antibodies as well as by differences in their mRNAs and gene structures | journal = J. Biol. Chem. | volume = 265 | issue = 18 | pages = 10733–9 | year = 1990 | pmid = 1693924 | doi =  }}
* {{cite journal | vauthors = Elkon KB, Hines JJ, Chu JL, Parnassa A | title = Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction | journal = J. Immunol. | volume = 145 | issue = 2 | pages = 636–43 | year = 1990 | pmid = 1694885 | doi =  }}
* {{cite journal | vauthors = Chu JL, Elkon KB | title = The small nuclear ribonucleoproteins, SmB and B', are products of a single gene | journal = Gene | volume = 97 | issue = 2 | pages = 311–2 | year = 1991 | pmid = 1825643 | doi = 10.1016/0378-1119(91)90069-N }}
* {{cite journal | vauthors = Sharpe NG, Williams DG, Latchman DS | title = Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation | journal = Mol. Cell. Biol. | volume = 10 | issue = 12 | pages = 6817–20 | year = 1990 | pmid = 2174118 | pmc = 362965 | doi =  10.1128/mcb.10.12.6817}}
* {{cite journal | vauthors = Schmauss C, McAllister G, Ohosone Y, Hardin JA, Lerner MR | title = A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B' | journal = Nucleic Acids Res. | volume = 17 | issue = 4 | pages = 1733–43 | year = 1989 | pmid = 2522186 | pmc = 331831 | doi = 10.1093/nar/17.4.1733 }}
* {{cite journal | vauthors = Feeney RJ, Sauterer RA, Feeney JL, Zieve GW | title = Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles | journal = J. Biol. Chem. | volume = 264 | issue = 10 | pages = 5776–83 | year = 1989 | pmid = 2522439 | doi =  }}
* {{cite journal | vauthors = Ohosone Y, Mimori T, Griffith A, Akizuki M, Homma M, Craft J, Hardin JA | title = Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 11 | pages = 4249–53 | year = 1989 | pmid = 2524838 | pmc = 287428 | doi = 10.1073/pnas.86.11.4249 }}
* {{cite journal | vauthors = van Dam A, Winkel I, Zijlstra-Baalbergen J, Smeenk R, Cuypers HT | title = Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part | journal = EMBO J. | volume = 8 | issue = 12 | pages = 3853–60 | year = 1989 | pmid = 2531083 | pmc = 402073 | doi =  }}
* {{cite journal | vauthors = Huntriss JD, Latchman DS, Williams DG | title = Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B' | journal = Clin. Exp. Immunol. | volume = 92 | issue = 2 | pages = 263–7 | year = 1993 | pmid = 7683587 | pmc = 1554819 | doi = 10.1111/j.1365-2249.1993.tb03390.x }}
* {{cite journal | vauthors = Gerrelli D, Grimaldi K, Horn D, Mahadeva U, Sharpe N, Latchman DS | title = The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein | journal = J. Mol. Cell. Cardiol. | volume = 25 | issue = 3 | pages = 321–9 | year = 1993 | pmid = 8510173 | doi = 10.1006/jmcc.1993.1038 }}
* {{cite journal | vauthors = Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V | title = PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb | journal = Oncogene | volume = 14 | issue = 2 | pages = 145–55 | year = 1997 | pmid = 9010216 | doi = 10.1038/sj.onc.1200825 }}
* {{cite journal | vauthors = Liu Q, Fischer U, Wang F, Dreyfuss G | title = The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins | journal = Cell | volume = 90 | issue = 6 | pages = 1013–21 | year = 1997 | pmid = 9323129 | doi = 10.1016/S0092-8674(00)80367-0 }}
* {{cite journal | vauthors = Fury MG, Zhang W, Christodoulopoulos I, Zieve GW | title = Multiple protein: protein interactions between the snRNP common core proteins | journal = Exp. Cell Res. | volume = 237 | issue = 1 | pages = 63–9 | year = 1997 | pmid = 9417867 | doi = 10.1006/excr.1997.3750 }}
* {{cite journal | vauthors = Bedford MT, Reed R, Leder P | title = WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 18 | pages = 10602–7 | year = 1998 | pmid = 9724750 | pmc = 27941 | doi = 10.1073/pnas.95.18.10602 }}
* {{cite journal | vauthors = Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K | title = Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs | journal = Cell | volume = 96 | issue = 3 | pages = 375–87 | year = 1999 | pmid = 10025403 | doi = 10.1016/S0092-8674(00)80550-4 }}
* {{cite journal | vauthors = Gray TA, Smithwick MJ, Schaldach MA, Martone DL, Graves JA, McCarrey JR, Nicholls RD | title = Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci | journal = Nucleic Acids Res. | volume = 27 | issue = 23 | pages = 4577–84 | year = 1999 | pmid = 10556313 | pmc = 148745 | doi = 10.1093/nar/27.23.4577 }}
* {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94 | year = 1999 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181 }}
* {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G | title = Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli | journal = J. Cell Biol. | volume = 148 | issue = 6 | pages = 1177–86 | year = 2000 | pmid = 10725331 | pmc = 2174312 | doi = 10.1083/jcb.148.6.1177 }}
{{Refend}}
 
{{PDB Gallery|geneid=6628}}
{{Ribonucleoproteins}}
 
 
{{Gene-20-stub}}

Revision as of 01:47, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.[1][2]

Function

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.[2]

Interactions

SNRPB has been shown to interact with DDX20[3] and Coilin.[4]

References

  1. ↑ Griffith AJ, Schmauss C, Craft J (July 1992). "The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site". Gene. 114 (2): 195–201. doi:10.1016/0378-1119(92)90574-9. PMID 1376292.
  2. ↑ 2.0 2.1 "Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1".
  3. ↑ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
  4. ↑ Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (October 2001). "Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein". Genes Dev. 15 (20): 2720–9. doi:10.1101/gad.908401. PMC 312817. PMID 11641277.

Further reading


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