SFRS6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Splicing factor, arginine/serine-rich 6''' is a [[protein]] that in humans is encoded by the ''SFRS6'' [[gene]].<ref name="pmid7556075">{{cite journal | vauthors = Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR | title = Identification and characterization of three members of the human SR family of pre-mRNA splicing factors | journal = The EMBO Journal | volume = 14 | issue = 17 | pages = 4336–49 | date = September 1995 | pmid = 7556075 | pmc = 394518 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6431| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Splicing factor, arginine/serine-rich 6
| HGNCid = 10788
| Symbol = SFRS6
| AltSymbols =; B52; MGC5045; SRP55
| OMIM = 601944
| ECnumber = 
| Homologene = 74570
| MGIid = 1915246
| GeneAtlas_image1 = PBB_GE_SFRS6_208804_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFRS6_206108_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006376 |text = mRNA splice site selection}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6431
    | Hs_Ensembl = ENSG00000124193
    | Hs_RefseqProtein = NP_006266
    | Hs_RefseqmRNA = NM_006275
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 41519932
    | Hs_GenLoc_end = 41525659
    | Hs_Uniprot = Q13247
    | Mm_EntrezGene = 67996
    | Mm_Ensembl = ENSMUSG00000016921
    | Mm_RefseqmRNA = XM_980333
    | Mm_RefseqProtein = XP_985427
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 162622982
    | Mm_GenLoc_end = 162628564
    | Mm_Uniprot = 
  }}
}}
'''Splicing factor, arginine/serine-rich 6''', also known as '''SFRS6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6431| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in [[alternative splicing]]. The encoded nuclear protein belongs to the splicing factor [[SR protein|SR]] family and has been shown to bind with and modulate another member of the family, [[SFRS12]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.<ref name="entrez">{{cite web | title = Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6431| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zahler AM, Lane WS, Stolk JA, Roth MB | title = SR proteins: a conserved family of pre-mRNA splicing factors | journal = Genes & Development | volume = 6 | issue = 5 | pages = 837–47 | date = May 1992 | pmid = 1577277 | doi = 10.1101/gad.6.5.837 }}
| citations =
* {{cite journal | vauthors = Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA | title = A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer | journal = Molecular and Cellular Biology | volume = 15 | issue = 9 | pages = 4898–907 | date = September 1995 | pmid = 7651409 | pmc = 230736 | doi =  }}
*{{cite journal | author=Zahler AM, Lane WS, Stolk JA, Roth MB |title=SR proteins: a conserved family of pre-mRNA splicing factors. |journal=Genes Dev. |volume=6 |issue= 5 |pages= 837-47 |year= 1992 |pmid= 1577277 |doi= }}
* {{cite journal | vauthors = Gui JF, Lane WS, Fu XD | title = A serine kinase regulates intracellular localization of splicing factors in the cell cycle | journal = Nature | volume = 369 | issue = 6482 | pages = 678–82 | date = June 1994 | pmid = 8208298 | doi = 10.1038/369678a0 }}
*{{cite journal  | author=Screaton GR, Cáceres JF, Mayeda A, ''et al.'' |title=Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4336-49 |year= 1995 |pmid= 7556075 |doi=  }}
* {{cite journal | vauthors = Nagel RJ, Lancaster AM, Zahler AM | title = Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55 | journal = Rna | volume = 4 | issue = 1 | pages = 11–23 | date = January 1998 | pmid = 9436904 | pmc = 1369592 | doi =  }}
*{{cite journal | author=Ramchatesingh J, Zahler AM, Neugebauer KM, ''et al.'' |title=A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4898-907 |year= 1995 |pmid= 7651409 |doi=  }}
* {{cite journal | vauthors = Liu HX, Zhang M, Krainer AR | title = Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins | journal = Genes & Development | volume = 12 | issue = 13 | pages = 1998–2012 | date = July 1998 | pmid = 9649504 | pmc = 316967 | doi = 10.1101/gad.12.13.1998 }}
*{{cite journal | author=Gui JF, Lane WS, Fu XD |title=A serine kinase regulates intracellular localization of splicing factors in the cell cycle. |journal=Nature |volume=369 |issue= 6482 |pages= 678-82 |year= 1994 |pmid= 8208298 |doi= 10.1038/369678a0 }}
* {{cite journal | vauthors = Lemaire R, Winne A, Sarkissian M, Lafyatis R | title = SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation | journal = European Journal of Immunology | volume = 29 | issue = 3 | pages = 823–37 | date = March 1999 | pmid = 10092085 | doi = 10.1002/(SICI)1521-4141(199903)29:03<823::AID-IMMU823>3.0.CO;2-C }}
*{{cite journal | author=Nagel RJ, Lancaster AM, Zahler AM |title=Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55. |journal=RNA |volume=4 |issue= 1 |pages= 11-23 |year= 1998 |pmid= 9436904 |doi=  }}
* {{cite journal | vauthors = Paillard F | title = A novel soluble chimera for the treatment of familial hypercholesterolemia | journal = Human Gene Therapy | volume = 10 | issue = 7 | pages = 1093–4 | date = May 1999 | pmid = 10340541 | doi = 10.1089/10430349950018085 }}
*{{cite journal | author=Liu HX, Zhang M, Krainer AR |title=Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. |journal=Genes Dev. |volume=12 |issue= 13 |pages= 1998-2012 |year= 1998 |pmid= 9649504 |doi= }}
* {{cite journal | vauthors = Barnard DC, Patton JG | title = Identification and characterization of a novel serine-arginine-rich splicing regulatory protein | journal = Molecular and Cellular Biology | volume = 20 | issue = 9 | pages = 3049–57 | date = May 2000 | pmid = 10757789 | pmc = 85584 | doi = 10.1128/MCB.20.9.3049-3057.2000 }}
*{{cite journal | author=Lemaire R, Winne A, Sarkissian M, Lafyatis R |title=SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation. |journal=Eur. J. Immunol. |volume=29 |issue= 3 |pages= 823-37 |year= 1999 |pmid= 10092085 |doi= }}
* {{cite journal | vauthors = Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM | title = Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1 | journal = Molecular Cell | volume = 6 | issue = 2 | pages = 307–16 | date = August 2000 | pmid = 10983978 | doi = 10.1016/S1097-2765(00)00031-9 }}
*{{cite journal | author=Paillard F |title=A novel soluble chimera for the treatment of familial hypercholesterolemia. |journal=Hum. Gene Ther. |volume=10 |issue= 7 |pages= 1093-4 |year= 1999 |pmid= 10340541 |doi= 10.1089/10430349950018085 }}
* {{cite journal | vauthors = Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW | title = A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 | journal = Genomics | volume = 76 | issue = 1-3 | pages = 45–57 | date = August 2001 | pmid = 11549316 | doi = 10.1006/geno.2001.6584 }}
*{{cite journal | author=Barnard DC, Patton JG |title=Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3049-57 |year= 2000 |pmid= 10757789 |doi= }}
* {{cite journal | vauthors = Tran Q, Coleman TP, Roesser JR | title = Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer | journal = Biochimica et Biophysica Acta | volume = 1625 | issue = 2 | pages = 141–52 | date = January 2003 | pmid = 12531473 | doi = 10.1016/S0167-4781(02)00600-0 }}
*{{cite journal | author=Monsalve M, Wu Z, Adelmant G, ''et al.'' |title=Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 307-16 |year= 2000 |pmid= 10983978 |doi= }}
* {{cite journal | vauthors = Tran Q, Roesser JR | title = SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing | journal = Biochemistry | volume = 42 | issue = 4 | pages = 951–7 | date = February 2003 | pmid = 12549914 | doi = 10.1021/bi026753a }}
*{{cite journal | author=Fossey SC, Mychaleckyj JC, Pendleton JK, ''et al.'' |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45-57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
* {{cite journal | vauthors = Lai MC, Lin RI, Tarn WY | title = Differential effects of hyperphosphorylation on splicing factor SRp55 | journal = The Biochemical Journal | volume = 371 | issue = Pt 3 | pages = 937–45 | date = May 2003 | pmid = 12549978 | pmc = 1223332 | doi = 10.1042/BJ20021827 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Pind MT, Watson PH | title = SR protein expression and CD44 splicing pattern in human breast tumours | journal = Breast Cancer Research and Treatment | volume = 79 | issue = 1 | pages = 75–82 | date = May 2003 | pmid = 12779084 | doi = 10.1023/A:1023338718974 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins | journal = Molecular and Cellular Biology | volume = 23 | issue = 21 | pages = 7437–47 | date = November 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }}
*{{cite journal  | author=Tran Q, Coleman TP, Roesser JR |title=Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer. |journal=Biochim. Biophys. Acta |volume=1625 |issue= 2 |pages= 141-52 |year= 2003 |pmid= 12531473 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Tran Q, Roesser JR |title=SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. |journal=Biochemistry |volume=42 |issue= 4 |pages= 951-7 |year= 2003 |pmid= 12549914 |doi= 10.1021/bi026753a }}
*{{cite journal | author=Lai MC, Lin RI, Tarn WY |title=Differential effects of hyperphosphorylation on splicing factor SRp55. |journal=Biochem. J. |volume=371 |issue= Pt 3 |pages= 937-45 |year= 2003 |pmid= 12549978 |doi= 10.1042/BJ20021827 }}
*{{cite journal | author=Pind MT, Watson PH |title=SR protein expression and CD44 splicing pattern in human breast tumours. |journal=Breast Cancer Res. Treat. |volume=79 |issue= 1 |pages= 75-82 |year= 2004 |pmid= 12779084 |doi= }}
*{{cite journal | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi= }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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Revision as of 06:13, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.[1][2]

Function

The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.[2]

References

  1. ↑ Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR (September 1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". The EMBO Journal. 14 (17): 4336–49. PMC 394518. PMID 7556075.
  2. ↑ 2.0 2.1 "Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SFRS6&oldid=1419518"