SERPINB1: Difference between revisions

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{{Infobox_gene}}
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'''Leukocyte elastase inhibitor''' (LEI) also known as '''serpin B1''' is a [[protein]] that in humans is encoded by the ''SERPINB1'' [[gene]]. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.<ref name="pmid1376927">{{cite journal |vauthors=Remold-O'Donnell E, Chin J, Alberts M | title = Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 12 | pages = 5635–9 |date=Jul 1992 | pmid = 1376927 | pmc = 49347 | doi =10.1073/pnas.89.12.5635  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1992| accessdate = }}</ref><ref name="Benarafa_2005">{{cite journal |vauthors=Benarafa C, Remold-O'Donnell E | title = The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 32 | pages = 11367–72 |date=August 2005 | pmid = 16055559 | pmc = 1183561 | doi = 10.1073/pnas.0502934102 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.<ref name="Benarafa_2005"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Serpin peptidase inhibitor, clade B (ovalbumin), member 1
| HGNCid = 3311
| Symbol = SERPINB1
| AltSymbols =; EI; ELANH2; LEI; M/NEI; MNEI; PI2
| OMIM = 130135
| ECnumber = 
| Homologene = 69399
| MGIid = 1913472
| GeneAtlas_image1 = PBB_GE_SERPINB1_213572_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SERPINB1_212268_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1992
    | Hs_Ensembl = ENSG00000021355
    | Hs_RefseqProtein = NP_109591
    | Hs_RefseqmRNA = NM_030666
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 2777565
    | Hs_GenLoc_end = 2787239
    | Hs_Uniprot = P30740
    | Mm_EntrezGene = 66222
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_025429
    | Mm_RefseqProtein = NP_079705
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Serpin peptidase inhibitor, clade B (ovalbumin), member 1''', also known as '''SERPINB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1992| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
SerpinB1 is a cytoplasmic serine protease inhibitor of  [[neutrophil granulocyte|polymorphonuclear neutrophils]]. Among other serine proteases, it specifically inhibits  [[neutrophil elastase]], PR3 and [[cathepsin G]], all found in neutrophil granules, by a suicide inhibition mechanism. SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice. In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown. Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.<ref name="pmid21791661"><!-- SerpinB1 function in regulating inflammation -->{{cite journal |vauthors=Gong D, Farley K, White M, Hartshorn KL, Benarafa C, Remold-O'Donnell E | title = Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection | journal = J. Infect. Dis. | volume = 204 | issue = 4 | pages = 592–600 |date=August 2011 | pmid = 21791661 | doi = 10.1093/infdis/jir352 | pmc=3144176}}</ref><ref name="pmid21248149"><!-- SerpinB1 protects neutrophil reserves in bone marrow -->{{cite journal |vauthors=Benarafa C, LeCuyer TE, Baumann M, Stolley JM, Cremona TP, Remold-O'Donnell E | title = SerpinB1 protects the mature neutrophil reserve in the bone marrow | journal = J. Leukoc. Biol. | volume = 90 | issue = 1 | pages = 21–9 |date=July 2011 | pmid = 21248149 | doi = 10.1189/jlb.0810461 | pmc=3114599}}</ref><ref name="pmid17664292"><!-- SerpinB1 preserves lung defense functions -->{{cite journal |vauthors=Benarafa C, Priebe GP, Remold-O'Donnell E | title = The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection | journal = J. Exp. Med. | volume = 204 | issue = 8 | pages = 1901–9 |date=August 2007 | pmid = 17664292 | pmc = 2118684 | doi = 10.1084/jem.20070494 | url = }}</ref>
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| summary_text =  
}}


==See also==
==See also==
Line 59: Line 11:


==References==
==References==
{{reflist|2}}
{{reflist | 35em}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 35em}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Rasmussen HH, van Damme J, Puype M, etal |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 }}
| citations =
*{{cite journal  |vauthors=Packard BZ, Lee SS, Remold-O'Donnell E, Komoriya A |title=A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes. |journal=Biochim. Biophys. Acta |volume=1269 |issue= 1 |pages= 41–50 |year= 1995 |pmid= 7578269 |doi=10.1016/0167-4889(95)00113-7 }}
*{{cite journal | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi= }}
*{{cite journal  |vauthors=Sugimori T, Cooley J, Hoidal JR, Remold-O'Donnell E |title=Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor. |journal=Am. J. Respir. Cell Mol. Biol. |volume=13 |issue= 3 |pages= 314–22 |year= 1995 |pmid= 7654387 |doi=  10.1165/ajrcmb.13.3.7654387}}
*{{cite journal  | author=Remold-O'Donnell E, Chin J, Alberts M |title=Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5635-9 |year= 1992 |pmid= 1376927 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Packard BZ, Lee SS, Remold-O'Donnell E, Komoriya A |title=A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes. |journal=Biochim. Biophys. Acta |volume=1269 |issue= 1 |pages= 41-50 |year= 1995 |pmid= 7578269 |doi=  }}
*{{cite journal  |vauthors=Evans E, Cooley J, Remold-O'Donnell E |title=Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor. |journal=Genomics |volume=28 |issue= 2 |pages= 235–40 |year= 1996 |pmid= 8530031 |doi= 10.1006/geno.1995.1136 }}
*{{cite journal  | author=Sugimori T, Cooley J, Hoidal JR, Remold-O'Donnell E |title=Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor. |journal=Am. J. Respir. Cell Mol. Biol. |volume=13 |issue= 3 |pages= 314-22 |year= 1995 |pmid= 7654387 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Zeng W, Silverman GA, Remold-O'Donnell E |title=Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. |journal=Gene |volume=213 |issue= 1-2 |pages= 179–87 |year= 1998 |pmid= 9630619 |doi=10.1016/S0378-1119(98)00189-9 }}
*{{cite journal  | author=Evans E, Cooley J, Remold-O'Donnell E |title=Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor. |journal=Genomics |volume=28 |issue= 2 |pages= 235-40 |year= 1996 |pmid= 8530031 |doi= 10.1006/geno.1995.1136 }}
*{{cite journal   |vauthors=Sun J, Stephens R, Mirza G, etal |title=A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 273–7 |year= 1999 |pmid= 9858835 |doi=10.1159/000015118 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Perani P, Zeggai S, Torriglia A, Courtois Y |title=Mutations on the hinge region of leukocyte elastase inhibitor determine the loss of inhibitory function. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 3 |pages= 841–4 |year= 2000 |pmid= 10924364 |doi= 10.1006/bbrc.2000.3191 }}
*{{cite journal  | author=Zeng W, Silverman GA, Remold-O'Donnell E |title=Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. |journal=Gene |volume=213 |issue= 1-2 |pages= 179-87 |year= 1998 |pmid= 9630619 |doi=  }}
*{{cite journal   |vauthors=Cooley J, Takayama TK, Shapiro SD, etal |title=The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. |journal=Biochemistry |volume=40 |issue= 51 |pages= 15762–70 |year= 2002 |pmid= 11747453 |doi=10.1021/bi0113925 }}
*{{cite journal | author=Sun J, Stephens R, Mirza G, ''et al.'' |title=A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 273-7 |year= 1999 |pmid= 9858835 |doi=  }}
*{{cite journal   |vauthors=Korkmaz B, Attucci S, Hazouard E, etal |title=Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39074–81 |year= 2002 |pmid= 12114510 |doi= 10.1074/jbc.M202918200 }}
*{{cite journal  | author=Perani P, Zeggai S, Torriglia A, Courtois Y |title=Mutations on the hinge region of leukocyte elastase inhibitor determine the loss of inhibitory function. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 3 |pages= 841-4 |year= 2000 |pmid= 10924364 |doi= 10.1006/bbrc.2000.3191 }}
*{{cite journal   |vauthors=Benarafa C, Cooley J, Zeng W, etal |title=Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42028–33 |year= 2003 |pmid= 12189154 |doi= 10.1074/jbc.M207080200 }}
*{{cite journal | author=Cooley J, Takayama TK, Shapiro SD, ''et al.'' |title=The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. |journal=Biochemistry |volume=40 |issue= 51 |pages= 15762-70 |year= 2002 |pmid= 11747453 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Korkmaz B, Attucci S, Hazouard E, ''et al.'' |title=Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39074-81 |year= 2002 |pmid= 12114510 |doi= 10.1074/jbc.M202918200 }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Benarafa C, Cooley J, Zeng W, ''et al.'' |title=Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42028-33 |year= 2003 |pmid= 12189154 |doi= 10.1074/jbc.M207080200 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  |vauthors=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931–40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931-40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a }}
}}
{{refend}}
{{refend}}


==External links==
==External links==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.006 I04.006]
* {{MeshName|SERPINB1+protein,+human}}
* {{MeshName|SERPINB1+protein,+human}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Serpins}}
{{Serpins}}
[[Category:Serine protease inhibitors]]
[[Category:Serine protease inhibitors]]
{{WikiDoc Sources}}
 
 
{{gene-6-stub}}

Latest revision as of 06:08, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.[1][2][3]

MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.[3]

Function

SerpinB1 is a cytoplasmic serine protease inhibitor of polymorphonuclear neutrophils. Among other serine proteases, it specifically inhibits neutrophil elastase, PR3 and cathepsin G, all found in neutrophil granules, by a suicide inhibition mechanism. SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice. In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown. Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.[4][5][6]

See also

References

  1. ↑ Remold-O'Donnell E, Chin J, Alberts M (Jul 1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A. 89 (12): 5635–9. doi:10.1073/pnas.89.12.5635. PMC 49347. PMID 1376927.
  2. ↑ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1".
  3. ↑ 3.0 3.1 Benarafa C, Remold-O'Donnell E (August 2005). "The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11367–72. doi:10.1073/pnas.0502934102. PMC 1183561. PMID 16055559.
  4. ↑ Gong D, Farley K, White M, Hartshorn KL, Benarafa C, Remold-O'Donnell E (August 2011). "Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection". J. Infect. Dis. 204 (4): 592–600. doi:10.1093/infdis/jir352. PMC 3144176. PMID 21791661.
  5. ↑ Benarafa C, LeCuyer TE, Baumann M, Stolley JM, Cremona TP, Remold-O'Donnell E (July 2011). "SerpinB1 protects the mature neutrophil reserve in the bone marrow". J. Leukoc. Biol. 90 (1): 21–9. doi:10.1189/jlb.0810461. PMC 3114599. PMID 21248149.
  6. ↑ Benarafa C, Priebe GP, Remold-O'Donnell E (August 2007). "The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection". J. Exp. Med. 204 (8): 1901–9. doi:10.1084/jem.20070494. PMC 2118684. PMID 17664292.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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