Roseola differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Roseola, also known as HHV-6 must be differentiated from all other childhood diseases that cause rash, and fever. The following table summarizes the differential diagnosis for roseola.

	Classification	Clinical manifestations
Subfamily alphavirinae	Herpes simplex type 1	Vesicular rash, perioral, rarely encephalitis, meningitis.
	Herpes simplex type 2 varicella-zoster virus	Disseminated vesicular rash at acquisition (chicken pox): localized vesicular rash with reactivation(zoster).
Subfamily betavirinae	Cytomegalovirus	Mononucleosi-like illness in healthy adults; Fever, pneumonia, and Hepatitis in immunocompromised adults.
	Human herpes virus 6	Acute febrile illness sometimes with rash (roseola infantum),
	Human herpes virus 7	May cause febrile illness sometimes with rash ( roseola-like).
Subfamily gammavirinae	Epstein-Bar virus	mononucleosis, lymphoma, nasopahryngeal carcinoma and hodgkins disease.
	Human herpes virus 8	Kaposi's sarcoma in immunocompromised.