Retroperitoneal fibrosis: Difference between revisions
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'''For patient information page click [[{{PAGENAME}} (patient information)|here]]''' | '''For patient information page click [[{{PAGENAME}} (patient information)|here]]''' | ||
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{{SK}} Ormond's disease | |||
==Overview== | ==Overview== | ||
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* Ormond JK. Bilateral ureteral obstruction due to envelopment and compression by an inflammatory retroperitoneal process. ''J Urol'' 1948;59:1072-79. | * Ormond JK. Bilateral ureteral obstruction due to envelopment and compression by an inflammatory retroperitoneal process. ''J Urol'' 1948;59:1072-79. | ||
* Ormond JK. Idiopathic retroperitoneal fibrosis: a discussion of the etiology. ''J Urol'' 1965;94:385-90. | * Ormond JK. Idiopathic retroperitoneal fibrosis: a discussion of the etiology. ''J Urol'' 1965;94:385-90. | ||
Revision as of 15:17, 8 November 2012
For patient information page click here
| Retroperitoneal fibrosis | |
| ICD-10 | N13.5 |
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| ICD-9 | 593.4 |
| DiseasesDB | 11445 |
| MeSH | D012185 |
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Retroperitoneal fibrosis Microchapters |
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Differentiating Retroperitoneal fibrosis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Retroperitoneal fibrosis On the Web |
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American Roentgen Ray Society Images of Retroperitoneal fibrosis |
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Risk calculators and risk factors for Retroperitoneal fibrosis |
Steven C. Campbell, M.D., Ph.D.
Synonyms and keywords: Ormond's disease
Overview
Retroperitoneal fibrosis or Ormond's disease is a disease featuring the proliferation of fibrous tissue in the retroperitoneum, the compartment of the body containing the kidneys, aorta, renal tract and various other structures. It may present with lower back pain, renal failure, hypertension, deep vein thrombosis and other obstructive symptoms.
Causes
Its association with various immune-related conditions and response to immunosuppression have led to speculations as to the autoimmune etiology of idiopathic RPF. One-third of the cases are secondary to malignancy, medication (methysergide, hydralazine, beta blockers), aortic aneurysm or certain infections.
Treatment
In the absence of severe urinary tract obstruction (which generally requires surgery with omental wrapping) treatment is generally with glucocorticoids initially, followed by DMARDs either as steroid-sparing agents or if refractory on steroids. The SERM tamoxifen has shown to improve the condition in various small trials, although the exact mechanism of its action remains unclear.
References
- van Bommel EF. Retroperitoneal fibrosis. Neth J Med 2002;60:231-42. PMID 12365466.
- Ormond JK. Bilateral ureteral obstruction due to envelopment and compression by an inflammatory retroperitoneal process. J Urol 1948;59:1072-79.
- Ormond JK. Idiopathic retroperitoneal fibrosis: a discussion of the etiology. J Urol 1965;94:385-90.