Radixin

Radixin
File:PBB Protein RDX image.jpg PDB rendering based on 1gc6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gc6​, 1gc7​, 1j19​, 2d10​, 2d11​, 2d2q​, 2yvc​
Identifiers
Symbols	RDX ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37707
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RDX 204969 s at tn.png
File:PBB GE RDX 212397 at tn.png
File:PBB GE RDX 212398 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Radixin, also known as RDX, is a human gene.

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.

Further reading

• Hoeflich KP, Ikura M (2005). "Radixin: cytoskeletal adopter and signaling protein". Int. J. Biochem. Cell Biol. 36 (11): 2131–6. doi:10.1016/j.biocel.2003.11.018. PMID 15313460.
• Matarrese P, Malorni W (2006). "Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death". Cell Death Differ. 12 Suppl 1: 932–41. doi:10.1038/sj.cdd.4401582. PMID 15818415.
• Sato N, Funayama N, Nagafuchi A; et al. (1992). "A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites". J. Cell. Sci. 103 ( Pt 1): 131–43. PMID 1429901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilgenbus KK, Milatovich A, Francke U, Furthmayr H (1993). "Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes". Genomics. 16 (1): 199–206. doi:10.1006/geno.1993.1159. PMID 8486357.CS1 maint: Multiple names: authors list (link)
• Hirao M, Sato N, Kondo T; et al. (1996). "Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway". J. Cell Biol. 135 (1): 37–51. PMID 8858161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Stemmer-Rachamimov AO, Gonzalez-Agosti C, Xu L; et al. (1997). "Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system". J. Neuropathol. Exp. Neurol. 56 (6): 735–42. PMID 9184664.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi K, Sasaki T, Mammoto A; et al. (1997). "Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein". J. Biol. Chem. 272 (37): 23371–5. PMID 9287351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kondo T, Takeuchi K, Doi Y; et al. (1997). "ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis". J. Cell Biol. 139 (3): 749–58. PMID 9348291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murthy A, Gonzalez-Agosti C, Cordero E; et al. (1998). "NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins". J. Biol. Chem. 273 (3): 1273–6. PMID 9430655.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsui T, Maeda M, Doi Y; et al. (1998). "Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association". J. Cell Biol. 140 (3): 647–57. PMID 9456324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yonemura S, Hirao M, Doi Y; et al. (1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. PMID 9472040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhartur SG, Goldenring JR (1998). "Mapping of ezrin dimerization using yeast two-hybrid screening". Biochem. Biophys. Res. Commun. 243 (3): 874–7. doi:10.1006/bbrc.1998.8196. PMID 9501018.
• Takahashi K, Sasaki T, Mammoto A; et al. (1998). "Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl". Oncogene. 16 (25): 3279–84. doi:10.1038/sj.onc.1201874. PMID 9681826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lamb RF, Roy C, Diefenbach TJ; et al. (2000). "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho". Nat. Cell Biol. 2 (5): 281–7. doi:10.1038/35010550. PMID 10806479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vaiskunaite R, Adarichev V, Furthmayr H; et al. (2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamada K, Shimizu T, Matsui T; et al. (2001). "Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of the adhesion protein ICAM-2". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 6): 891–2. PMID 11375520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kikuchi S, Hata M, Fukumoto K; et al. (2002). "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes". Nat. Genet. 31 (3): 320–5. doi:10.1038/ng905. PMID 12068294.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dickson TC, Mintz CD, Benson DL, Salton SR (2002). "Functional binding interaction identified between the axonal CAM L1 and members of the ERM family". J. Cell Biol. 157 (7): 1105–12. doi:10.1083/jcb.200111076. PMID 12070130.CS1 maint: Multiple names: authors list (link)
• Haddad LA, Smith N, Bowser M; et al. (2003). "The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton". J. Biol. Chem. 277 (46): 44180–6. doi:10.1074/jbc.M207211200. PMID 12226091.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)