View source for RUVBL2

{{Infobox_gene}}
'''RuvB-like 2 (E. coli)''', also known as '''RUVBL2''', is a human [[gene]] coding for a protein belonging to the [[AAA+]] family of proteins.

== Function ==

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.<ref>{{cite journal | vauthors = Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR | title = Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex | journal = Journal of Molecular Biology | volume = 366 | issue = 1 | pages = 179–92 | date = Feb 2007 | pmid = 17157868 | doi = 10.1016/j.jmb.2006.11.030 }}</ref> This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.<ref name="entrez">{{cite web | title = Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10856| accessdate = }}</ref>

== Interactions ==

RUVBL2 has been shown to [[Protein-protein interaction|interact]] with [[RuvB-like 1]]<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref> and [[Activating transcription factor 2]].<ref name=pmid11713276>{{cite journal | vauthors = Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z | title = TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage | journal = Molecular and Cellular Biology | volume = 21 | issue = 24 | pages = 8398–413 | date = Dec 2001 | pmid = 11713276 | pmc = 100004 | doi = 10.1128/MCB.21.24.8398-8413.2001 }}</ref>

== References ==
{{Reflist}}

== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Doyon Y, Côté J | title = The highly conserved and multifunctional NuA4 HAT complex | journal = Current Opinion in Genetics & Development | volume = 14 | issue = 2 | pages = 147–54 | date = Apr 2004 | pmid = 15196461 | doi = 10.1016/j.gde.2004.02.009 }}
* {{cite journal | vauthors = Kanemaki M, Kurokawa Y, Matsu-ura T, Makino Y, Masani A, Okazaki K, Morishita T, Tamura TA | title = TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a | journal = The Journal of Biological Chemistry | volume = 274 | issue = 32 | pages = 22437–44 | date = Aug 1999 | pmid = 10428817 | doi = 10.1074/jbc.274.32.22437 }}
* {{cite journal | vauthors = Salzer U, Kubicek M, Prohaska R | title = Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins | journal = Biochimica et Biophysica Acta | volume = 1446 | issue = 3 | pages = 365–70 | date = Sep 1999 | pmid = 10524211 | doi = 10.1016/S0167-4781(99)00104-9 }}
* {{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Research | volume = 10 | issue = 5 | pages = 703–13 | date = May 2000 | pmid = 10810093 | pmc = 310876 | doi = 10.1101/gr.10.5.703 }}
* {{cite journal | vauthors = Wood MA, McMahon SB, Cole MD | title = An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc | journal = Molecular Cell | volume = 5 | issue = 2 | pages = 321–30 | date = Feb 2000 | pmid = 10882073 | doi = 10.1016/S1097-2765(00)80427-X }}
* {{cite journal | vauthors = Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y | title = Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis | journal = Cell | volume = 102 | issue = 4 | pages = 463–73 | date = Aug 2000 | pmid = 10966108 | doi = 10.1016/S0092-8674(00)00051-9 }}
* {{cite journal | vauthors = Parfait B, Giovangrandi Y, Asheuer M, Laurendeau I, Olivi M, Vodovar N, Vidaud D, Vidaud M, Bièche I | title = Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3 | journal = Annales de Génétique | volume = 43 | issue = 2 | pages = 69–74 | year = 2000 | pmid = 10998447 | doi = 10.1016/S0003-3995(00)01016-9 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J | title = Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity | journal = The EMBO Journal | volume = 19 | issue = 22 | pages = 6121–30 | date = Nov 2000 | pmid = 11080158 | pmc = 305835 | doi = 10.1093/emboj/19.22.6121 }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z | title = TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage | journal = Molecular and Cellular Biology | volume = 21 | issue = 24 | pages = 8398–413 | date = Dec 2001 | pmid = 11713276 | pmc = 100004 | doi = 10.1128/MCB.21.24.8398-8413.2001 }}
* {{cite journal | vauthors = Park J, Wood MA, Cole MD | title = BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation | journal = Molecular and Cellular Biology | volume = 22 | issue = 5 | pages = 1307–16 | date = Mar 2002 | pmid = 11839798 | pmc = 134713 | doi = 10.1128/MCB.22.5.1307-1316.2002 }}
* {{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40362–7 | date = Oct 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}
* {{cite journal | vauthors = Watkins NJ, Dickmanns A, Lührmann R | title = Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP | journal = Molecular and Cellular Biology | volume = 22 | issue = 23 | pages = 8342–52 | date = Dec 2002 | pmid = 12417735 | pmc = 134055 | doi = 10.1128/MCB.22.23.8342-8352.2002 | url = http://pubman.mpdl.mpg.de/pubman/item/escidoc:641782/component/escidoc:2250325/641782.pdf }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
* {{cite journal | vauthors = Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW | title = Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 44 | pages = 42733–6 | date = Oct 2003 | pmid = 12963728 | doi = 10.1074/jbc.C300389200 }}
* {{cite journal | vauthors = Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W | title = Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI | journal = Science | volume = 302 | issue = 5648 | pages = 1208–12 | date = Nov 2003 | pmid = 14615539 | doi = 10.1126/science.1088401 }}
{{Refend}}

{{PDB Gallery|geneid=10856}}


{{Gene-19-stub}}