RRAS: Difference between revisions

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Latest revision as of 20:45, 8 November 2017

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.^[1]^[2]

Interactions

RRAS has been shown to interact with:

References

↑ Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (February 1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell. 48 (1): 137–46. doi:10.1016/0092-8674(87)90364-3. PMID 3098437.
↑ "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog".
↑ Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/s0888-7543(02)00008-3. PMID 12620389.
↑ Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/mcb.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
↑ Fernandez-Sarabia MJ, Bischoff JR (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature. 366 (6452): 274–5. doi:10.1038/366274a0. PMID 8232588.
↑ Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. 275 (7): 5222–7. doi:10.1074/jbc.275.7.5222. PMID 10671570.
↑ Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
↑ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (February 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.

Carboni JM, Yan N, Cox AD, Bustelo X, Graham SM, Lynch MJ, Weinmann R, Seizinger BR, Der CJ, Barbacid M (1995). "Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation". Oncogene. 10 (10): 1905–13. PMID 7761092.
Spaargaren M, Bischoff JR (1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
Fernandez-Sarabia MJ, Bischoff JR (1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature. 366 (6452): 274–5. doi:10.1038/366274a0. PMID 8232588.
Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". J. Biol. Chem. 274 (19): 13556–62. doi:10.1074/jbc.274.19.13556. PMID 10224125.
Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D, Ivanov IE, Philips MR (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi". Cell. 98 (1): 69–80. doi:10.1016/S0092-8674(00)80607-8. PMID 10412982.
Zou JX, Wang B, Kalo MS, Zisch AH, Pasquale EB, Ruoslahti E (1999). "An Eph receptor regulates integrin activity through R-Ras". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13813–8. doi:10.1073/pnas.96.24.13813. PMC 24147. PMID 10570155.
Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. 275 (7): 5222–7. doi:10.1074/jbc.275.7.5222. PMID 10671570.
Suzuki J, Kaziro Y, Koide H (2000). "Positive regulation of skeletal myogenesis by R-Ras". Oncogene. 19 (9): 1138–46. doi:10.1038/sj.onc.1203402. PMID 10713701.
Ohba Y, Mochizuki N, Yamashita S, Chan AM, Schrader JW, Hattori S, Nagashima K, Matsuda M (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3". J. Biol. Chem. 275 (26): 20020–6. doi:10.1074/jbc.M000981200. PMID 10777492.
Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE (2000). "The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function". Oncogene. 19 (43): 4961–9. doi:10.1038/sj.onc.1203876. PMID 11042683.
Tian X, Feig LA (2001). "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors". J. Biol. Chem. 276 (50): 47248–56. doi:10.1074/jbc.M107407200. PMID 11560935.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
Yu Y, Feig LA (2002). "Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells". Oncogene. 21 (49): 7557–68. doi:10.1038/sj.onc.1205961. PMID 12386818.
Kwong L, Wozniak MA, Collins AS, Wilson SD, Keely PJ (2003). "R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins". Mol. Cell. Biol. 23 (3): 933–49. doi:10.1128/MCB.23.3.933-949.2003. PMC 140691. PMID 12529399.
Rincón-Arano H, Rosales R, Mora N, Rodriguez-Castañeda A, Rosales C (2003). "R-Ras promotes tumor growth of cervical epithelial cells". Cancer. 97 (3): 575–85. doi:10.1002/cncr.11093. PMID 12548599.
Furuhjelm J, Peränen J (2003). "The C-terminal end of R-Ras contains a focal adhesion targeting signal". J. Cell Sci. 116 (Pt 18): 3729–38. doi:10.1242/jcs.00689. PMID 12890755.
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid3098437-1] Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (February 1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell. 48 (1): 137–46. doi:10.1016/0092-8674(87)90364-3. PMID 3098437.

[entrez-2] "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog".

[pmid12620389-3] Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/s0888-7543(02)00008-3. PMID 12620389.

[pmid10848612-4] Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/mcb.20.13.4870-4878.2000. PMC 85938. PMID 10848612.

[pmid8232588-5] Fernandez-Sarabia MJ, Bischoff JR (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature. 366 (6452): 274–5. doi:10.1038/366274a0. PMID 8232588.

[pmid10671570-6] Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. 275 (7): 5222–7. doi:10.1074/jbc.275.7.5222. PMID 10671570.

[pmid7809086-7] Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.

[pmid11857081-8] Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (February 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{about|the human protein|the Microsoft API and server software|Routing and Remote Access Service}}
-{{PBB_Controls
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{Infobox_gene}}
-{{GNF_Protein_box
+'''Ras-related protein R-Ras''' is a [[protein]] that in humans is encoded by the ''RRAS'' [[gene]].<ref name="pmid3098437">{{cite journal | vauthors = Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV | title = Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes | journal = Cell | volume = 48 | issue = 1 | pages = 137–46  | date = February 1987 | pmid = 3098437 | pmc =  | doi = 10.1016/0092-8674(87)90364-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6237| accessdate = }}</ref>
- | image = PBB_Protein_RRAS_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fn4.
- | PDB = {{PDB2|2fn4}}
- | Name = Related RAS viral (r-ras) oncogene homolog
- | HGNCid = 10447
- | Symbol = RRAS
- | AltSymbols =;
- | OMIM = 165090
-  | ECnumber =
- | Homologene = 4565
- | MGIid = 98179
-  | GeneAtlas_image1 = PBB_GE_RRAS_212647_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
- | Process = {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6237
-    | Hs_Ensembl = ENSG00000126458
-    | Hs_RefseqProtein = NP_006261
-    | Hs_RefseqmRNA = NM_006270
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 54830364
-    | Hs_GenLoc_end = 54835212
-    | Hs_Uniprot = P10301
-    | Mm_EntrezGene = 20130
-    | Mm_Ensembl = ENSMUSG00000038387
-    | Mm_RefseqmRNA = NM_009101
-    | Mm_RefseqProtein = NP_033127
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 44886032
-    | Mm_GenLoc_end = 44889683
-    | Mm_Uniprot = Q3U1N3
-  }}
-}}
-'''Related RAS viral (r-ras) oncogene homolog''', also known as '''RRAS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6237| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+RRAS has been shown to [[Protein-protein interaction|interact]] with:
-{{reflist|2}}
+{{div col|colwidth=20em}}
-==Further reading==
+* [[ARAF]],<ref name = pmid12620389>{{cite journal | vauthors = Yuryev A, Wennogle LP | title = Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis | journal = Genomics | volume = 81 | issue = 2 | pages = 112–25  | date = February 2003 | pmid = 12620389 | doi =  10.1016/s0888-7543(02)00008-3}}</ref><ref name = pmid10848612>{{cite journal | vauthors = Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP | title = Isoform-specific localization of A-RAF in mitochondria | journal = Mol. Cell. Biol. | volume = 20 | issue = 13 | pages = 4870–8  | date = July 2000 | pmid = 10848612 | pmc = 85938 | doi =  10.1128/mcb.20.13.4870-4878.2000}}</ref>
+* [[Bcl-2]],<ref name = pmid8232588>{{cite journal | vauthors = Fernandez-Sarabia MJ, Bischoff JR | title = Bcl-2 associates with the ras-related protein R-ras p23 | journal = Nature | volume = 366 | issue = 6452 | pages = 274–5  | date = November 1993 | pmid = 8232588 | doi = 10.1038/366274a0 }}</ref>
+* [[NCK1]],<ref name = pmid10671570>{{cite journal | vauthors = Wang B, Zou JX, Ek-Rylander B, Ruoslahti E | title = R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras | journal = J. Biol. Chem. | volume = 275 | issue = 7 | pages = 5222–7  | date = February 2000 | pmid = 10671570 | doi =  10.1074/jbc.275.7.5222}}</ref>
+* [[RALGDS]],<ref name = pmid7809086>{{cite journal | vauthors = Spaargaren M, Bischoff JR | title = Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 26 | pages = 12609–13  | date = December 1994 | pmid = 7809086 | pmc = 45488 | doi =  10.1073/pnas.91.26.12609}}</ref> and
+* [[RASSF5]].<ref name = pmid11857081>{{cite journal | vauthors = Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J | title = The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 | journal = Oncogene | volume = 21 | issue = 9 | pages = 1381–90  | date = February 2002 | pmid = 11857081 | doi = 10.1038/sj.onc.1205192 }}</ref>
+{{Div col end}}
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Carboni JM, Yan N, Cox AD, Bustelo X, Graham SM, Lynch MJ, Weinmann R, Seizinger BR, Der CJ, Barbacid M | title = Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation | journal = Oncogene | volume = 10 | issue = 10 | pages = 1905–13 | year = 1995 | pmid = 7761092 | doi =  }}
-| citations =
+* {{cite journal | vauthors = Spaargaren M, Bischoff JR | title = Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 26 | pages = 12609–13 | year = 1994 | pmid = 7809086 | pmc = 45488 | doi = 10.1073/pnas.91.26.12609 }}
-*{{cite journal  | author=Lowe DG, Capon DJ, Delwart E, ''et al.'' |title=Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. |journal=Cell |volume=48 |issue= 1 |pages= 137-46 |year= 1987 |pmid= 3098437 |doi=  }}
+* {{cite journal | vauthors = Fernandez-Sarabia MJ, Bischoff JR | title = Bcl-2 associates with the ras-related protein R-ras p23 | journal = Nature | volume = 366 | issue = 6452 | pages = 274–5 | year = 1993 | pmid = 8232588 | doi = 10.1038/366274a0 }}
-*{{cite journal  | author=Carboni JM, Yan N, Cox AD, ''et al.'' |title=Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation. |journal=Oncogene |volume=10 |issue= 10 |pages= 1905-13 |year= 1995 |pmid= 7761092 |doi=  }}
+* {{cite journal | vauthors = Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C | title = Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 13556–62 | year = 1999 | pmid = 10224125 | doi = 10.1074/jbc.274.19.13556 }}
-*{{cite journal  | author=Spaargaren M, Bischoff JR |title=Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12609-13 |year= 1995 |pmid= 7809086 |doi=  }}
+* {{cite journal | vauthors = Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D, Ivanov IE, Philips MR | title = Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi | journal = Cell | volume = 98 | issue = 1 | pages = 69–80 | year = 1999 | pmid = 10412982 | doi = 10.1016/S0092-8674(00)80607-8 }}
-*{{cite journal  | author=Fernandez-Sarabia MJ, Bischoff JR |title=Bcl-2 associates with the ras-related protein R-ras p23. |journal=Nature |volume=366 |issue= 6452 |pages= 274-5 |year= 1993 |pmid= 8232588 |doi= 10.1038/366274a0 }}
+* {{cite journal | vauthors = Zou JX, Wang B, Kalo MS, Zisch AH, Pasquale EB, Ruoslahti E | title = An Eph receptor regulates integrin activity through R-Ras | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 24 | pages = 13813–8 | year = 1999 | pmid = 10570155 | pmc = 24147 | doi = 10.1073/pnas.96.24.13813 }}
-*{{cite journal  | author=Linnemann T, Geyer M, Jaitner BK, ''et al.'' |title=Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13556-62 |year= 1999 |pmid= 10224125 |doi=  }}
+* {{cite journal | vauthors = Wang B, Zou JX, Ek-Rylander B, Ruoslahti E | title = R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras | journal = J. Biol. Chem. | volume = 275 | issue = 7 | pages = 5222–7 | year = 2000 | pmid = 10671570 | doi = 10.1074/jbc.275.7.5222 }}
-*{{cite journal  | author=Choy E, Chiu VK, Silletti J, ''et al.'' |title=Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. |journal=Cell |volume=98 |issue= 1 |pages= 69-80 |year= 1999 |pmid= 10412982 |doi= 10.1016/S0092-8674(00)80607-8 }}
+* {{cite journal | vauthors = Suzuki J, Kaziro Y, Koide H | title = Positive regulation of skeletal myogenesis by R-Ras | journal = Oncogene | volume = 19 | issue = 9 | pages = 1138–46 | year = 2000 | pmid = 10713701 | doi = 10.1038/sj.onc.1203402 }}
-*{{cite journal  | author=Zou JX, Wang B, Kalo MS, ''et al.'' |title=An Eph receptor regulates integrin activity through R-Ras. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13813-8 |year= 2000 |pmid= 10570155 |doi=  }}
+* {{cite journal | vauthors = Ohba Y, Mochizuki N, Yamashita S, Chan AM, Schrader JW, Hattori S, Nagashima K, Matsuda M | title = Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3 | journal = J. Biol. Chem. | volume = 275 | issue = 26 | pages = 20020–6 | year = 2000 | pmid = 10777492 | doi = 10.1074/jbc.M000981200 }}
-*{{cite journal  | author=Wang B, Zou JX, Ek-Rylander B, Ruoslahti E |title=R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 5222-7 |year= 2000 |pmid= 10671570 |doi=  }}
+* {{cite journal | vauthors = Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP | title = Isoform-specific localization of A-RAF in mitochondria | journal = Mol. Cell. Biol. | volume = 20 | issue = 13 | pages = 4870–8 | year = 2000 | pmid = 10848612 | pmc = 85938 | doi = 10.1128/MCB.20.13.4870-4878.2000 }}
-*{{cite journal  | author=Suzuki J, Kaziro Y, Koide H |title=Positive regulation of skeletal myogenesis by R-Ras. |journal=Oncogene |volume=19 |issue= 9 |pages= 1138-46 |year= 2000 |pmid= 10713701 |doi= 10.1038/sj.onc.1203402 }}
+* {{cite journal | vauthors = Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE | title = The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function | journal = Oncogene | volume = 19 | issue = 43 | pages = 4961–9 | year = 2000 | pmid = 11042683 | doi = 10.1038/sj.onc.1203876 }}
-*{{cite journal  | author=Ohba Y, Mochizuki N, Yamashita S, ''et al.'' |title=Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20020-6 |year= 2000 |pmid= 10777492 |doi= 10.1074/jbc.M000981200 }}
+* {{cite journal | vauthors = Tian X, Feig LA | title = Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors | journal = J. Biol. Chem. | volume = 276 | issue = 50 | pages = 47248–56 | year = 2001 | pmid = 11560935 | doi = 10.1074/jbc.M107407200 }}
-*{{cite journal  | author=Yuryev A, Ono M, Goff SA, ''et al.'' |title=Isoform-specific localization of A-RAF in mitochondria. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4870-8 |year= 2000 |pmid= 10848612 |doi=  }}
+* {{cite journal | vauthors = Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J | title = The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 | journal = Oncogene | volume = 21 | issue = 9 | pages = 1381–90 | year = 2002 | pmid = 11857081 | doi = 10.1038/sj.onc.1205192 }}
-*{{cite journal  | author=Oertli B, Han J, Marte BM, ''et al.'' |title=The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function. |journal=Oncogene |volume=19 |issue= 43 |pages= 4961-9 |year= 2000 |pmid= 11042683 |doi= 10.1038/sj.onc.1203876 }}
+* {{cite journal | vauthors = Yu Y, Feig LA | title = Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells | journal = Oncogene | volume = 21 | issue = 49 | pages = 7557–68 | year = 2002 | pmid = 12386818 | doi = 10.1038/sj.onc.1205961 }}
-*{{cite journal  | author=Tian X, Feig LA |title=Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47248-56 |year= 2002 |pmid= 11560935 |doi= 10.1074/jbc.M107407200 }}
+* {{cite journal | vauthors = Kwong L, Wozniak MA, Collins AS, Wilson SD, Keely PJ | title = R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins | journal = Mol. Cell. Biol. | volume = 23 | issue = 3 | pages = 933–49 | year = 2003 | pmid = 12529399 | pmc = 140691 | doi = 10.1128/MCB.23.3.933-949.2003 }}
-*{{cite journal  | author=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, ''et al.'' |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381-90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192 }}
+* {{cite journal | vauthors = Rincón-Arano H, Rosales R, Mora N, Rodriguez-Castañeda A, Rosales C | title = R-Ras promotes tumor growth of cervical epithelial cells | journal = Cancer | volume = 97 | issue = 3 | pages = 575–85 | year = 2003 | pmid = 12548599 | doi = 10.1002/cncr.11093 }}
-*{{cite journal  | author=Yu Y, Feig LA |title=Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells. |journal=Oncogene |volume=21 |issue= 49 |pages= 7557-68 |year= 2002 |pmid= 12386818 |doi= 10.1038/sj.onc.1205961 }}
+* {{cite journal | vauthors = Furuhjelm J, Peränen J | title = The C-terminal end of R-Ras contains a focal adhesion targeting signal | journal = J. Cell Sci. | volume = 116 | issue = Pt 18 | pages = 3729–38 | year = 2003 | pmid = 12890755 | doi = 10.1242/jcs.00689 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ | title = Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22353–61 | year = 2004 | pmid = 15031288 | doi = 10.1074/jbc.M312867200 }}
-*{{cite journal  | author=Kwong L, Wozniak MA, Collins AS, ''et al.'' |title=R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins. |journal=Mol. Cell. Biol. |volume=23 |issue= 3 |pages= 933-49 |year= 2003 |pmid= 12529399 |doi=  }}
-*{{cite journal  | author=Rincón-Arano H, Rosales R, Mora N, ''et al.'' |title=R-Ras promotes tumor growth of cervical epithelial cells. |journal=Cancer |volume=97 |issue= 3 |pages= 575-85 |year= 2003 |pmid= 12548599 |doi= 10.1002/cncr.11093 }}
-*{{cite journal  | author=Furuhjelm J, Peränen J |title=The C-terminal end of R-Ras contains a focal adhesion targeting signal. |journal=J. Cell. Sci. |volume=116 |issue= Pt 18 |pages= 3729-38 |year= 2004 |pmid= 12890755 |doi= 10.1242/jcs.00689 }}
-*{{cite journal  | author=Mitin NY, Ramocki MB, Zullo AJ, ''et al.'' |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353-61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }}
-}}
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-{{protein-stub}}
+{{PDB Gallery|geneid=6237}}
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RRAS: Difference between revisions

Latest revision as of 20:45, 8 November 2017

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