View source for RP6-213H19.1

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Serine/threonine protein kinase MST4
 | HGNCid =  
 | Symbol = RP6-213H19.1
 | AltSymbols =; MASK; MST4
 | OMIM = 300547
 | ECnumber =  
 | Homologene = 84402
 | MGIid = 1917665
 | GeneAtlas_image1 = PBB_GE_RP6-213H19.1_218499_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51765
    | Hs_Ensembl = ENSG00000134602
    | Hs_RefseqProtein = NP_001035917
    | Hs_RefseqmRNA = NM_001042452
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 130984974
    | Hs_GenLoc_end = 131037652
    | Hs_Uniprot = Q9P289
    | Mm_EntrezGene = 70415
    | Mm_Ensembl = ENSMUSG00000031112
    | Mm_RefseqmRNA = XM_985225
    | Mm_RefseqProtein = XP_990319
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 47114883
    | Mm_GenLoc_end = 47135951
    | Mm_Uniprot = Q99JT2
  }}
}}
'''Serine/threonine protein kinase MST4''', also known as '''RP6-213H19.1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51765| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51765| accessdate = }}</ref>
}}

==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Liu KC, Wang D |title=[Synthesis of n-substituted beta-methyl DL-aspartates as potential hypocholesteremics (author's transl)] |journal=Arch. Pharm. (Weinheim) |volume=308 |issue= 7 |pages= 564-70 |year= 1975 |pmid= 1164178 |doi=  }}
*{{cite journal  | author=Qian Z, Lin C, Espinosa R, ''et al.'' |title=Cloning and characterization of MST4, a novel Ste20-like kinase. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22439-45 |year= 2001 |pmid= 11306563 |doi= 10.1074/jbc.M009323200 }}
*{{cite journal  | author=Dan I, Watanabe NM, Kusumi A |title=The Ste20 group kinases as regulators of MAP kinase cascades. |journal=Trends Cell Biol. |volume=11 |issue= 5 |pages= 220-30 |year= 2001 |pmid= 11316611 |doi=  }}
*{{cite journal  | author=Lin JL, Chen HC, Fang HI, ''et al.'' |title=MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. |journal=Oncogene |volume=20 |issue= 45 |pages= 6559-69 |year= 2001 |pmid= 11641781 |doi= 10.1038/sj.onc.1204818 }}
*{{cite journal  | author=Dan I, Ong SE, Watanabe NM, ''et al.'' |title=Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 5929-39 |year= 2002 |pmid= 11741893 |doi= 10.1074/jbc.M110882200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sung V, Luo W, Qian D, ''et al.'' |title=The Ste20 kinase MST4 plays a role in prostate cancer progression. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3356-63 |year= 2003 |pmid= 12810671 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Preisinger C, Short B, De Corte V, ''et al.'' |title=YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. |journal=J. Cell Biol. |volume=164 |issue= 7 |pages= 1009-20 |year= 2004 |pmid= 15037601 |doi= 10.1083/jcb.200310061 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Chan EH, Nousiainen M, Chalamalasetty RB, ''et al.'' |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076-86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Ma X, Zhao H, Shan J, ''et al.'' |title=PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. |journal=Mol. Biol. Cell |volume=18 |issue= 6 |pages= 1965-78 |year= 2007 |pmid= 17360971 |doi= 10.1091/mbc.E06-07-0608 }}
}}
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