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{{Infobox_gene}}
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'''Regenerating islet-derived protein 4''' is a [[protein]] that in humans is encoded by the ''REG4'' [[gene]].<ref name="pmid11311942">{{cite journal |vauthors=Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK | title = Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV | journal = Biochim Biophys Acta | volume = 1518 | issue = 3 | pages = 287–93 |date=Apr 2001 | pmid = 11311942 | pmc =  | doi =  10.1016/s0167-4781(00)00284-0}}</ref><ref name="pmid12455032">{{cite journal |vauthors=Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T | title = Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas | journal = Int J Cancer | volume = 103 | issue = 2 | pages = 185–93 |date=Nov 2002 | pmid = 12455032 | pmc =  | doi = 10.1002/ijc.10788 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: REG4 regenerating islet-derived family, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83998| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Regenerating islet-derived family, member 4
| HGNCid = 22977
| Symbol = REG4
| AltSymbols =; GISP; REG-IV; RELP
| OMIM = 609846
| ECnumber =
| Homologene = 41671
  | MGIid = 1914959
  | Function = {{GNF_GO|id=GO:0005529 |text = sugar binding}}  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83998
    | Hs_Ensembl = ENSG00000134193
    | Hs_RefseqProtein = NP_114433
    | Hs_RefseqmRNA = NM_032044
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 120138164
    | Hs_GenLoc_end = 120155806
    | Hs_Uniprot = Q9BYZ8
    | Mm_EntrezGene = 67709
    | Mm_Ensembl = ENSMUSG00000027876
    | Mm_RefseqmRNA = NM_026328
    | Mm_RefseqProtein = NP_080604
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 98307558
    | Mm_GenLoc_end = 98322153
    | Mm_Uniprot = Q9D8G5
  }}
}}
'''Regenerating islet-derived family, member 4''', also known as '''REG4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: REG4 regenerating islet-derived family, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83998| accessdate = }}</ref>
 
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hartupee JC, Zhang H, Bonaldo MF, ''et al.'' |title=Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 3 |pages= 287-93 |year= 2001 |pmid= 11311942 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Violette S, Festor E, Pandrea-Vasile I, ''et al.'' |title=Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. |journal=Int. J. Cancer |volume=103 |issue= 2 |pages= 185-93 |year= 2003 |pmid= 12455032 |doi= 10.1002/ijc.10788 }}
*{{cite journal  | author=Kämäräinen M |title=RELP, a Novel Human Reg-Like Protein with Up-Regulated Expression in Inflammatory and Metaplastic Gastrointestinal Mucosa |journal=Am. J. Pathol. |volume=163 |issue= 1 |pages= 11–20 |year= 2003 |pmid= 12819006 |doi= 10.1016/S0002-9440(10)63625-5| pmc=1868159  |name-list-format=vanc| author2=Heiskala K  | author3=Knuutila S  | display-authors=3  | last4=Heiskala  | first4=M  | last5=Winqvist  | first5=O  | last6=Andersson  | first6=LC }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Zhang Y |title=Overexpression of Reg IV in colorectal adenoma |journal=Cancer Lett. |volume=200 |issue= 1 |pages= 69–76 |year= 2003 |pmid= 14550954 |doi=10.1016/S0304-3835(03)00460-9  |name-list-format=vanc| author2=Lai M  | author3=Lv B  | display-authors=3  | last4=Gu  | first4=Xuemei  | last5=Wang  | first5=Huiping  | last6=Zhu  | first6=Yimin  | last7=Zhu  | first7=Yangli  | last8=Shao  | first8=Lina  | last9=Wang  | first9=Guofeng }}
*{{cite journal  | author=Kämäräinen M, Heiskala K, Knuutila S, ''et al.'' |title=RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. |journal=Am. J. Pathol. |volume=163 |issue= 1 |pages= 11-20 |year= 2003 |pmid= 12819006 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Zhang Y, Lai M, Lv B, ''et al.'' |title=Overexpression of Reg IV in colorectal adenoma. |journal=Cancer Lett. |volume=200 |issue= 1 |pages= 69-76 |year= 2003 |pmid= 14550954 |doi=  }}
*{{cite journal  |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal  | author=Gu Z |title=Reg IV: a promising marker of hormone refractory metastatic prostate cancer |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2237–43 |year= 2005 |pmid= 15788672 |doi= 10.1158/1078-0432.CCR-04-0356 |name-list-format=vanc| author2=Rubin MA  | author3=Yang Y  | display-authors=3  | last4=Deprimo  | first4=SE  | last5=Zhao  | first5=H  | last6=Horvath  | first6=S  | last7=Brooks  | first7=JD  | last8=Loda  | first8=M  | last9=Reiter  | first9=RE }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Bishnupuri KS |title=Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas |journal=Gastroenterology |volume=130 |issue= 1 |pages= 137–49 |year= 2006 |pmid= 16401477 |doi= 10.1053/j.gastro.2005.10.001 |name-list-format=vanc| author2=Luo Q  | author3=Murmu N  | display-authors=3  | last4=Houchen  | first4=C  | last5=Anant  | first5=S  | last6=Dieckgraefe  | first6=B }}
*{{cite journal  | author=Gu Z, Rubin MA, Yang Y, ''et al.'' |title=Reg IV: a promising marker of hormone refractory metastatic prostate cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2237-43 |year= 2005 |pmid= 15788672 |doi= 10.1158/1078-0432.CCR-04-0356 }}
*{{cite journal  | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |name-list-format=vanc| author2=Barlow KF  | author3=McLay KE  | display-authors=3  | last4=Kaul  | first4=R.  | last5=Swarbreck  | first5=D.  | last6=Dunham  | first6=A.  | last7=Scott  | first7=C. E.  | last8=Howe  | first8=K. L.  | last9=Woodfine  | first9=K. }}
*{{cite journal  | author=Bishnupuri KS, Luo Q, Murmu N, ''et al.'' |title=Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. |journal=Gastroenterology |volume=130 |issue= 1 |pages= 137-49 |year= 2006 |pmid= 16401477 |doi= 10.1053/j.gastro.2005.10.001 }}
*{{cite journal  | author=Takehara A |title=Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4 |journal=Cancer Sci. |volume=97 |issue= 11 |pages= 1191–7 |year= 2006 |pmid= 16918991 |doi= 10.1111/j.1349-7006.2006.00297.x |name-list-format=vanc| author2=Eguchi H  | author3=Ohigashi H  | display-authors=3  | last4=Ishikawa  | first4=Osamu  | last5=Kasugai  | first5=Tsutomu  | last6=Hosokawa  | first6=Masayo  | last7=Katagiri  | first7=Toyomasa  | last8=Nakamura  | first8=Yusuke  | last9=Nakagawa  | first9=Hidewaki }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Takehara A, Eguchi H, Ohigashi H, ''et al.'' |title=Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. |journal=Cancer Sci. |volume=97 |issue= 11 |pages= 1191-7 |year= 2006 |pmid= 16918991 |doi= 10.1111/j.1349-7006.2006.00297.x }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:05, 14 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Regenerating islet-derived protein 4 is a protein that in humans is encoded by the REG4 gene.[1][2][3]

References

  1. ↑ Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta. 1518 (3): 287–93. doi:10.1016/s0167-4781(00)00284-0. PMID 11311942.
  2. ↑ Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas". Int J Cancer. 103 (2): 185–93. doi:10.1002/ijc.10788. PMID 12455032.
  3. ↑ "Entrez Gene: REG4 regenerating islet-derived family, member 4".

Further reading



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