RASSF5: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ras association domain-containing protein 5''' is a [[protein]] that in humans is encoded by the ''RASSF5 or F5'' [[gene]].<ref name="pmid11978988">{{cite journal | vauthors = Yao R, Wang Y, You M | title = Chromosome mapping and sequence variation of the murine Ras effector gene Nore1 | journal = Cytogenetics and Cell Genetics | volume = 95 | issue = 1-2 | pages = 126–8 | date = Apr 2002 | pmid = 11978988 | pmc =  | doi = 10.1159/000057035 }}</ref><ref name="pmid11965544">{{cite journal | vauthors = Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP | title = RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1 | journal = Oncogene | volume = 21 | issue = 17 | pages = 2713–20 | date = Apr 2002 | pmid = 11965544 | pmc =  | doi = 10.1038/sj.onc.1205365 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83593| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RASSF5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fnf.
| PDB = {{PDB2|2fnf}}
| Name = Ras association (RalGDS/AF-6) domain family 5
| HGNCid = 17609
| Symbol = RASSF5
| AltSymbols =; MGC10823; MGC17344; Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3
| OMIM = 607020
| ECnumber = 
| Homologene = 10296
| MGIid = 1926375
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83593
    | Hs_Ensembl = ENSG00000136653
    | Hs_RefseqProtein = NP_113625
    | Hs_RefseqmRNA = NM_031437
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 204747502
    | Hs_GenLoc_end = 204829230
    | Hs_Uniprot = Q8WWW0
    | Mm_EntrezGene = 54354
    | Mm_Ensembl = ENSMUSG00000026430
    | Mm_RefseqmRNA = NM_018750
    | Mm_RefseqProtein = NP_061220
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 133003956
    | Mm_GenLoc_end = 133072724
    | Mm_Uniprot = Q5EBH1
  }}
}}
'''Ras association (RalGDS/AF-6) domain family 5''', also known as '''RASSF5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83593| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83593| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RASSF5 has been shown to [[Protein-protein interaction|interact]] with [[RRAS]],<ref name=pmid11857081>{{cite journal | vauthors = Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J | title = The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 | journal = Oncogene | volume = 21 | issue = 9 | pages = 1381–90 | date = Feb 2002 | pmid = 11857081 | doi = 10.1038/sj.onc.1205192 }}</ref> [[RAP2A]],<ref name=pmid11857081/> [[MRAS]]<ref name=pmid11857081/> and [[RASSF1]].<ref name=pmid11857081/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kumari G, Singhal PK, Suryaraja R, Mahalingam S | title = Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation | journal = Journal of Molecular Biology | volume = 397 | issue = 1 | pages = 89–109 | date = Mar 2010 | pmid = 20064523 | doi = 10.1016/j.jmb.2010.01.005 }}
| citations =  
* {{cite journal | vauthors = Vavvas D, Li X, Avruch J, Zhang XF | title = Identification of Nore1 as a potential Ras effector | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5439–42 | date = Mar 1998 | pmid = 9488663 | doi = 10.1074/jbc.273.10.5439 }}
*{{cite journal | author=Vavvas D, Li X, Avruch J, Zhang XF |title=Identification of Nore1 as a potential Ras effector. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5439-42 |year= 1998 |pmid= 9488663 |doi= }}
* {{cite journal | vauthors = Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J | title = The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 | journal = Oncogene | volume = 21 | issue = 9 | pages = 1381–90 | date = Feb 2002 | pmid = 11857081 | doi = 10.1038/sj.onc.1205192 }}
*{{cite journal | author=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, ''et al.'' |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381-90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192 }}
* {{cite journal | vauthors = Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J | title = Identification of a novel Ras-regulated proapoptotic pathway | journal = Current Biology | volume = 12 | issue = 4 | pages = 253–65 | date = Feb 2002 | pmid = 11864565 | doi = 10.1016/S0960-9822(02)00683-8 }}
*{{cite journal | author=Khokhlatchev A, Rabizadeh S, Xavier R, ''et al.'' |title=Identification of a novel Ras-regulated proapoptotic pathway. |journal=Curr. Biol. |volume=12 |issue= 4 |pages= 253-65 |year= 2002 |pmid= 11864565 |doi=  }}
* {{cite journal | vauthors = Vos MD, Martinez A, Ellis CA, Vallecorsa T, Clark GJ | title = The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung | journal = The Journal of Biological Chemistry | volume = 278 | issue = 24 | pages = 21938–43 | date = Jun 2003 | pmid = 12676952 | doi = 10.1074/jbc.M211019200 }}
*{{cite journal  | author=Tommasi S, Dammann R, Jin SG, ''et al.'' |title=RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. |journal=Oncogene |volume=21 |issue= 17 |pages= 2713-20 |year= 2002 |pmid= 11965544 |doi= 10.1038/sj.onc.1205365 }}
* {{cite journal | vauthors = Katagiri K, Maeda A, Shimonaka M, Kinashi T | title = RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1 | journal = Nature Immunology | volume = 4 | issue = 8 | pages = 741–8 | date = Aug 2003 | pmid = 12845325 | doi = 10.1038/ni950 }}
*{{cite journal  | author=Yao R, Wang Y, You M |title=Chromosome mapping and sequence variation of the murine Ras effector gene Nore1. |journal=Cytogenet. Cell Genet. |volume=95 |issue= 1-2 |pages= 126-8 |year= 2002 |pmid= 11978988 |doi=  }}
* {{cite journal | vauthors = Chen J, Lui WO, Vos MD, Clark GJ, Takahashi M, Schoumans J, Khoo SK, Petillo D, Lavery T, Sugimura J, Astuti D, Zhang C, Kagawa S, Maher ER, Larsson C, Alberts AS, Kanayama HO, Teh BT | title = The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas | journal = Cancer Cell | volume = 4 | issue = 5 | pages = 405–13 | date = Nov 2003 | pmid = 14667507 | doi = 10.1016/S1535-6108(03)00269-1 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J | title = Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras | journal = The Biochemical Journal | volume = 381 | issue = Pt 2 | pages = 453–62 | date = Jul 2004 | pmid = 15109305 | pmc = 1133852 | doi = 10.1042/BJ20040025 }}
*{{cite journal | author=Vos MD, Martinez A, Ellis CA, ''et al.'' |title=The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21938-43 |year= 2003 |pmid= 12676952 |doi= 10.1074/jbc.M211019200 }}
* {{cite journal | vauthors = Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M | title = CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer | journal = Oncogene | volume = 23 | issue = 53 | pages = 8695–9 | date = Nov 2004 | pmid = 15378027 | doi = 10.1038/sj.onc.1207914 }}
*{{cite journal | author=Katagiri K, Maeda A, Shimonaka M, Kinashi T |title=RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. |journal=Nat. Immunol. |volume=4 |issue= 8 |pages= 741-8 |year= 2003 |pmid= 12845325 |doi= 10.1038/ni950 }}
* {{cite journal | vauthors = Fujita H, Fukuhara S, Sakurai A, Yamagishi A, Kamioka Y, Nakaoka Y, Masuda M, Mochizuki N | title = Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes | journal = The Journal of Biological Chemistry | volume = 280 | issue = 6 | pages = 5022–31 | date = Feb 2005 | pmid = 15569673 | doi = 10.1074/jbc.M409701200 }}
*{{cite journal | author=Chen J, Lui WO, Vos MD, ''et al.'' |title=The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. |journal=Cancer Cell |volume=4 |issue= 5 |pages= 405-13 |year= 2004 |pmid= 14667507 |doi= }}
* {{cite journal | vauthors = Nakamura N, Carney JA, Jin L, Kajita S, Pallares J, Zhang H, Qian X, Sebo TJ, Erickson LA, Lloyd RV | title = RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors | journal = Laboratory Investigation | volume = 85 | issue = 9 | pages = 1065–75 | date = Sep 2005 | pmid = 15980887 | doi = 10.1038/labinvest.3700306 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Foukakis T, Au AY, Wallin G, Geli J, Forsberg L, Clifton-Bligh R, Robinson BG, Lui WO, Zedenius J, Larsson C | title = The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 91 | issue = 3 | pages = 1143–9 | date = Mar 2006 | pmid = 16352687 | doi = 10.1210/jc.2005-1372 }}
*{{cite journal | author=Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J |title=Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. |journal=Biochem. J. |volume=381 |issue= Pt 2 |pages= 453-62 |year= 2004 |pmid= 15109305 |doi= 10.1042/BJ20040025 }}
* {{cite journal | vauthors = Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV | title = The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway | journal = The Journal of Biological Chemistry | volume = 281 | issue = 12 | pages = 8143–52 | date = Mar 2006 | pmid = 16421102 | doi = 10.1074/jbc.M511837200 }}
*{{cite journal | author=Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M |title=CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. |journal=Oncogene |volume=23 |issue= 53 |pages= 8695-9 |year= 2004 |pmid= 15378027 |doi= 10.1038/sj.onc.1207914 }}
* {{cite journal | vauthors = Macheiner D, Heller G, Kappel S, Bichler C, Stättner S, Ziegler B, Kandioler D, Wrba F, Schulte-Hermann R, Zöchbauer-Müller S, Grasl-Kraupp B | title = NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma | journal = Journal of Hepatology | volume = 45 | issue = 1 | pages = 81–9 | date = Jul 2006 | pmid = 16516329 | doi = 10.1016/j.jhep.2005.12.017 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R | title = Nore1B regulates TCR signaling via Ras and Carma1 | journal = Cellular Signalling | volume = 18 | issue = 10 | pages = 1647–54 | date = Oct 2006 | pmid = 16520020 | pmc = 3204664 | doi = 10.1016/j.cellsig.2006.01.015 }}
*{{cite journal  | author=Fujita H, Fukuhara S, Sakurai A, ''et al.'' |title=Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 5022-31 |year= 2005 |pmid= 15569673 |doi= 10.1074/jbc.M409701200 }}
*{{cite journal | author=Nakamura N, Carney JA, Jin L, ''et al.'' |title=RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors. |journal=Lab. Invest. |volume=85 |issue= 9 |pages= 1065-75 |year= 2005 |pmid= 15980887 |doi= 10.1038/labinvest.3700306 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Foukakis T, Au AY, Wallin G, ''et al.'' |title=The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 3 |pages= 1143-9 |year= 2006 |pmid= 16352687 |doi= 10.1210/jc.2005-1372 }}
*{{cite journal | author=Moshnikova A, Frye J, Shay JW, ''et al.'' |title=The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. |journal=J. Biol. Chem. |volume=281 |issue= 12 |pages= 8143-52 |year= 2006 |pmid= 16421102 |doi= 10.1074/jbc.M511837200 }}
*{{cite journal | author=Macheiner D, Heller G, Kappel S, ''et al.'' |title=NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma. |journal=J. Hepatol. |volume=45 |issue= 1 |pages= 81-9 |year= 2006 |pmid= 16516329 |doi= 10.1016/j.jhep.2005.12.017 }}
*{{cite journal | author=Ishiguro K, Avruch J, Landry A, ''et al.'' |title=Nore1B regulates TCR signaling via Ras and Carma1. |journal=Cell. Signal. |volume=18 |issue= 10 |pages= 1647-54 |year= 2006 |pmid= 16520020 |doi= 10.1016/j.cellsig.2006.01.015 }}
}}
{{refend}}
{{refend}}
 
{{PDB Gallery|geneid=83593}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 08:56, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.[1][2][3]

Function

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

RASSF5 has been shown to interact with RRAS,[4] RAP2A,[4] MRAS[4] and RASSF1.[4]

References

  1. ↑ Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenetics and Cell Genetics. 95 (1–2): 126–8. doi:10.1159/000057035. PMID 11978988.
  2. ↑ Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene. 21 (17): 2713–20. doi:10.1038/sj.onc.1205365. PMID 11965544.
  3. ↑ 3.0 3.1 "Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5".
  4. ↑ 4.0 4.1 4.2 4.3 Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.

Further reading

  • Kumari G, Singhal PK, Suryaraja R, Mahalingam S (Mar 2010). "Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation". Journal of Molecular Biology. 397 (1): 89–109. doi:10.1016/j.jmb.2010.01.005. PMID 20064523.
  • Vavvas D, Li X, Avruch J, Zhang XF (Mar 1998). "Identification of Nore1 as a potential Ras effector". The Journal of Biological Chemistry. 273 (10): 5439–42. doi:10.1074/jbc.273.10.5439. PMID 9488663.
  • Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
  • Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J (Feb 2002). "Identification of a novel Ras-regulated proapoptotic pathway". Current Biology. 12 (4): 253–65. doi:10.1016/S0960-9822(02)00683-8. PMID 11864565.
  • Vos MD, Martinez A, Ellis CA, Vallecorsa T, Clark GJ (Jun 2003). "The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung". The Journal of Biological Chemistry. 278 (24): 21938–43. doi:10.1074/jbc.M211019200. PMID 12676952.
  • Katagiri K, Maeda A, Shimonaka M, Kinashi T (Aug 2003). "RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1". Nature Immunology. 4 (8): 741–8. doi:10.1038/ni950. PMID 12845325.
  • Chen J, Lui WO, Vos MD, Clark GJ, Takahashi M, Schoumans J, Khoo SK, Petillo D, Lavery T, Sugimura J, Astuti D, Zhang C, Kagawa S, Maher ER, Larsson C, Alberts AS, Kanayama HO, Teh BT (Nov 2003). "The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas". Cancer Cell. 4 (5): 405–13. doi:10.1016/S1535-6108(03)00269-1. PMID 14667507.
  • Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J (Jul 2004). "Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras". The Biochemical Journal. 381 (Pt 2): 453–62. doi:10.1042/BJ20040025. PMC 1133852. PMID 15109305.
  • Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M (Nov 2004). "CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer". Oncogene. 23 (53): 8695–9. doi:10.1038/sj.onc.1207914. PMID 15378027.
  • Fujita H, Fukuhara S, Sakurai A, Yamagishi A, Kamioka Y, Nakaoka Y, Masuda M, Mochizuki N (Feb 2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". The Journal of Biological Chemistry. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.
  • Nakamura N, Carney JA, Jin L, Kajita S, Pallares J, Zhang H, Qian X, Sebo TJ, Erickson LA, Lloyd RV (Sep 2005). "RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors". Laboratory Investigation. 85 (9): 1065–75. doi:10.1038/labinvest.3700306. PMID 15980887.
  • Foukakis T, Au AY, Wallin G, Geli J, Forsberg L, Clifton-Bligh R, Robinson BG, Lui WO, Zedenius J, Larsson C (Mar 2006). "The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion". The Journal of Clinical Endocrinology and Metabolism. 91 (3): 1143–9. doi:10.1210/jc.2005-1372. PMID 16352687.
  • Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV (Mar 2006). "The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway". The Journal of Biological Chemistry. 281 (12): 8143–52. doi:10.1074/jbc.M511837200. PMID 16421102.
  • Macheiner D, Heller G, Kappel S, Bichler C, Stättner S, Ziegler B, Kandioler D, Wrba F, Schulte-Hermann R, Zöchbauer-Müller S, Grasl-Kraupp B (Jul 2006). "NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma". Journal of Hepatology. 45 (1): 81–9. doi:10.1016/j.jhep.2005.12.017. PMID 16516329.
  • Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R (Oct 2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cellular Signalling. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMC 3204664. PMID 16520020.
Retrieved from "https://www.wikidoc.org/index.php?title=RASSF5&oldid=1410918"