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Latest revision as of 07:18, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[1][2][3]

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[3]

Interactions

RASSF2 has been shown to interact with KRAS.[4]

References

  1. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  2. Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169.
  3. 3.0 3.1 "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2".
  4. Vos, Michele D; Ellis Chad A; Elam Candice; Ulku Aylin S; Taylor Barbara J; Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. United States. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. ISSN 0021-9258. PMID 12732644.

Further reading