RASA3

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.[1][2][3]

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.[3]

Interactions

RASA3 has been shown to interact with HCK.[4]

References

  1. Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF (Sep 1995). "Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family". Nature. 376 (6540): 527–30. Bibcode:1995Natur.376..527C. doi:10.1038/376527a0. PMID 7637787.
  2. Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BV, Dempsey CE, Cullen PJ (Feb 1998). "Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting". Curr Biol. 7 (12): 1007–10. doi:10.1016/S0960-9822(06)00423-4. PMID 9382842.
  3. 3.0 3.1 "Entrez Gene: RASA3 RAS p21 protein activator 3".
  4. Briggs, S D; Bryant S S; Jove R; Sanderson S D; Smithgall T E (Jun 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. UNITED STATES. 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. ISSN 0021-9258. PMID 7782336.

Further reading