Pyloric stenosis pathophysiology: Difference between revisions
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*However, infantile hypertrophic pyloric stenosis (IHPS) may result from abnormal innervation of the pyloric [[smooth muscle]]. | *However, infantile hypertrophic pyloric stenosis (IHPS) may result from abnormal innervation of the pyloric [[smooth muscle]]. | ||
*Evidence of increased [[collagen]] production and abnormal amounts of [[extracellular matrix protein]]s has also been seen in patients with hypertrophic pyloric [[muscle]].<ref name="pmid9553181">{{cite journal| author=Ohshiro K, Puri P| title=Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress. | journal=Pediatr Surg Int | year= 1998 | volume= 13 | issue= 4 | pages= 243-52 | pmid=9553181 | doi=10.1007/s003830050308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9553181 }} </ref> | *Evidence of increased [[collagen]] production and abnormal amounts of [[extracellular matrix protein]]s has also been seen in patients with hypertrophic pyloric [[muscle]].<ref name="pmid9553181">{{cite journal| author=Ohshiro K, Puri P| title=Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress. | journal=Pediatr Surg Int | year= 1998 | volume= 13 | issue= 4 | pages= 243-52 | pmid=9553181 | doi=10.1007/s003830050308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9553181 }} </ref> | ||
*The [[pathophysiology]] for adult-onset hypertrophic pyloric stenosis | *The [[pathophysiology]] for adult-onset hypertrophic pyloric stenosis is not comprehensively understood. | ||
== Genetics == | == Genetics == | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
The pathogenesis of infantile hypertrophic pyloric stenosis is not completely understood. However, infantile hypertrophic pyloric stenosis may result from abnormal innervation of the pyloric smooth muscle.
Pathophysiology
The pathogenesis of infantile hypertrophic pyloric stenosis is not completely understood.
- However, infantile hypertrophic pyloric stenosis (IHPS) may result from abnormal innervation of the pyloric smooth muscle.
- Evidence of increased collagen production and abnormal amounts of extracellular matrix proteins has also been seen in patients with hypertrophic pyloric muscle.[1]
- The pathophysiology for adult-onset hypertrophic pyloric stenosis is not comprehensively understood.
Genetics
In relatives of probands of infantile hypertrophic pyloric stenosis patients and monozygotic cotwins the recurrence pattern did not depict a single major inheritance.[2]
Associated Conditions of Infantile Hypertrophic Pyloric Stenosis
Various conditions associated with infantile pyloric stenosis include:[3]
- Neuromuscular disorders
- Connective tissue disorders
- Metabolic disorders
- Intracellular signalling pathway disturbances
- Intercellular communication disturbances
- Ciliopathies
- DNA-repair abnormalities
- Transcription regulation disorders
- MAPK-pathway abnormalities
- Lymphatic abnormalities
- Environmental factors
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Ohshiro K, Puri P (1998). "Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress". Pediatr Surg Int. 13 (4): 243–52. doi:10.1007/s003830050308. PMID 9553181.
- ↑ Mitchell LE, Risch N (1993). "The genetics of infantile hypertrophic pyloric stenosis. A reanalysis". Am J Dis Child. 147 (11): 1203–11. PMID 8237916.
- ↑ Peeters B, Benninga MA, Hennekam RC (2012). "Infantile hypertrophic pyloric stenosis--genetics and syndromes". Nat Rev Gastroenterol Hepatol. 9 (11): 646–60. doi:10.1038/nrgastro.2012.133. PMID 22777173.